期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms23105353
关键词
Solea senegalensis; pleuronectiformes; genetic maps; cytogenomics; chromosome evolution; karyotype; repetitive sequences; comparative genomics
资金
- Spanish Ministry of Economy and Competitiveness, FEDER [RTI2018-096847-B-C21, RTI2018-096847-B-C22]
- Junta de Andalucia-FEDER Grant [P20-00938]
The chromosome evolution of Solea senegalensis, a commercially-important flatfish species, was studied using a cytogenomics approach and synteny analysis with two reference flatfish species. It was found that repetitive sequences played a role in the evolution of bi-armed and acrocentric chromosomes, with differences in distribution and abundance of repetitive elements suggesting their involvement in remodeling processes during evolution.
The Pleuronectiformes order, which includes several commercially-important species, has undergone extensive chromosome evolution. One of these species is Solea senegalensis, a flatfish with 2n = 42 chromosomes. In this study, a cytogenomics approach and integration with previous maps was applied to characterize the karyotype of the species. Synteny analysis of S. senegalensis was carried out using two flatfish as a reference: Cynoglossus semilaevis and Scophthalmus maximus. Most S. senegalensis chromosomes (or chromosome arms for metacentrics and submetacentrics) showed a one-to-one macrosyntenic pattern with the other two species. In addition, we studied how repetitive sequences could have played a role in the evolution of S. senegalensis bi-armed (3, and 5-9) and acrocentric (11, 12 and 16) chromosomes, which showed the highest rearrangements compared with the reference species. A higher abundance of TEs (Transposable Elements) and other repeated elements was observed adjacent to telomeric regions on chromosomes 3, 7, 9 and 16. However, on chromosome 11, a greater abundance of DNA transposons was detected in interstitial BACs. This chromosome is syntenic with several chromosomes of the other two flatfish species, suggesting rearrangements during its evolution. A similar situation was also found on chromosome 16 (for microsatellites and low complexity sequences), but not for TEs (retroelements and DNA transposons). These differences in the distribution and abundance of repetitive elements in chromosomes that have undergone remodeling processes during the course of evolution also suggest a possible role for simple repeat sequences in rearranged regions.
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