Immune Modulation Using Extracellular Vesicles Encapsulated with MicroRNAs as Novel Drug Delivery Systems

Review Immunology

Role of inhibitory B cell co-receptors in B cell self-tolerance to non-protein antigens*

Takeshi Tsubata

Summary: Antibody production to non-protein antigens involves T cell-independent mechanisms, while inhibitory B cell co-receptors suppress B cell response to non-protein self-antigens.

IMMUNOLOGICAL REVIEWS (2022)

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Article Oncology

Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway

Xiang Li et al.

Summary: This study reveals a novel mechanism by which tumors modulate the microenvironment through ROS-induced down-regulation of miR-155-5p, which favors tumor growth and immunosuppression. Targeting miR-155-5p can effectively inhibit tumor growth and improve the anti-tumor immune response by downregulating PD-L1 and other immunosuppressive factors.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy

Reza Hosseini et al.

Summary: This paper reviews the role of TDEs in impairing NK cells and discusses potential approaches to counter the effects. NK cells, as important components of the immune system, have significant potential in cancer treatment.

MOLECULAR CANCER (2022)

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Article Pharmacology & Pharmacy

Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications

Yu-Xin Xu et al.

Summary: This article reviews the role of exosomal non-coding RNAs in diabetic complications and analyzes their potential as new biomarkers and cell-free therapies. It provides new ideas for the prevention, diagnosis, and treatment of diabetic complications.

PHARMACOLOGICAL RESEARCH (2022)

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Review Immunology

Clinical and diagnostic potential of regulatory T cell markers: From bench to bedside

Mohammad Hossein Haddadi et al.

Summary: Regulatory T (Treg) cells are heterogeneous immune cell populations essential for maintaining immune tolerance. Phenotypic heterogeneity caused by different pathological conditions makes identification and differentiation challenging. Utilizing suitable isolation panels designed for different purposes is crucial for addressing the issue of Treg purification.

TRANSPLANT IMMUNOLOGY (2022)

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Review Chemistry, Multidisciplinary

Exosomes as Natural Nanocarriers for RNA-Based Therapy and Prophylaxis

Andrey Gorshkov et al.

Summary: Exosomes, as natural nanocontainers, actively secrete and transmit molecular signals between cells, playing important roles in diagnosis and prognosis. Their ability to transport biologically active molecules and protect them from degradation makes them ideal delivery carriers for therapeutic RNA. The potential of exosomal surface functionalization allows for improved targeting to specific organs, tissues, and cells. However, the development of an effective technology for loading RNA into exosomes is yet to be resolved.

NANOMATERIALS (2022)

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Review Immunology

HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease

Jose Manuel Martin-Villa et al.

Summary: HLA-G is a non-classical HLA class I molecule with immunomodulatory properties that is involved in various processes such as organ transplantation, viral infections, cancer progression, and autoimmune diseases. Its immunosuppressive effect is exerted through interaction with its receptors on immune cells.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Instructive Cues of Thymic T Cell Selection

Magali Irla

Summary: During thymic development, signals provided by specific cells control the selection of T cells, resulting in the generation of a T cell repertoire capable of responding to foreign antigens while tolerating self-antigens. This review summarizes our current understanding of the signals involved in the selection of regulatory T cells and highlights the functional diversity of thymic antigen-presenting cell subsets implicated in T cell selection.

ANNUAL REVIEW OF IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Redox Activation of Mitochondrial DAMPs and the Metabolic Consequences for Development of Autoimmunity

Andreas Koenig et al.

Summary: The study discusses the role of mitochondria in autoimmune diseases, where excessive or prolonged exposure to ROS can cause innate immune signaling dysfunction and contribute to systemic inflammation.

ANTIOXIDANTS & REDOX SIGNALING (2022)

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Review Cell Biology

Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus

Nasim Bolouri et al.

Summary: Systemic lupus erythematosus (SLE) is a multisystemic rheumatic disease that primarily affects women of childbearing age. The common symptoms of SLE closely resemble those of other autoimmune and non-autoimmune disorders. This article provides an overview of the most up-to-date information on immune system-related factors, cells, and cytokines involved in the pathogenesis of SLE.

INFLAMMATION RESEARCH (2022)

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Review Medicine, Research & Experimental

Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

Ala Amiri et al.

Summary: Nanocarriers, especially exosomes, have the potential to overcome barriers in drug delivery due to their stability and inherent capability to shuttle biomolecules. However, research on exosomes as RNA delivery systems, particularly for mRNA, is limited. Therefore, it is important to investigate the application of exosomes in mRNA-based therapies.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Review Dentistry, Oral Surgery & Medicine

Dendritic cells a critical link to alveolar bone loss and systemic disease risk in periodontitis: Immunotherapeutic implications

Ahmed R. El-Awady et al.

Summary: Extensive research has revealed the complex mechanisms behind the immunopathogenesis of periodontitis. Dendritic cells play a crucial role in this process, being invaded by Porphyromonas gingivalis and releasing exosomes that promote immune cell senescence and bone loss. These findings contribute to the development of new immunotherapeutic approaches for promoting human health and longevity.

PERIODONTOLOGY 2000 (2022)

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Review Immunology

Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects

Hongxia Jiang et al.

Summary: Exosomes are small vesicles that mediate intercellular communication by transferring various components. Hypoxia influences the content and effects of exosomes. Hypoxic exosomes derived from tumor cells lead to different biological effects depending on the recipient units. Understanding the characteristics of hypoxic exosomes provides new insight into the pathogenesis of hypoxia-related diseases.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Cell Biology

The Role of Extracellular Vesicles in Cancer-Nerve Crosstalk of the Peripheral Nervous System

Yuanning Guo et al.

Summary: The pathogenic operations of cancer-nerve crosstalk and the roles of extracellular vesicles (EVs) in this process have gained significant attention in recent years. By promoting interdisciplinary research and collaboration, important advancements in the diagnosis and treatment of cancer-nerve interaction can be achieved.

CELLS (2022)

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Review Oncology

Potential clinical applications of exosomes in the diagnosis, treatment, and prognosis of cardiovascular diseases: a narrative review

Xuyang Chen et al.

Summary: This narrative review focuses on the role of exosomes in cardiovascular diseases (CVDs) and their potential clinical applications. The specific changes in exosome cargos, such as miRNAs and proteins, are found to be associated with the occurrence and development of CVDs, making them meaningful for the diagnosis and prognosis of CVDs. Additionally, exosomes can also be utilized as drug transporters and potential therapeutic methods. Overall, exosomes are expected to serve as meaningful tools in the diagnosis, treatment, and prognosis of CVDs.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Review Oncology

Tumor-derived exosomes in hypoxic microenvironment: release mechanism, biological function and clinical application

Da Qian et al.

Summary: Hypoxia, a characteristic of solid tumors, is closely related to the aggressiveness and unfavorable outcomes of diseases. Communication between cancer cells and their microenvironment plays a critical role in cancer progression, and recent studies have shown that this communication includes not only secreted molecules, but also exosomes secreted by tumor cells. Exosomes, nano-scale extracellular vesicles, carry molecular characteristics and cargo of the source cell, participating in intercellular communication through different pathways. Hypoxia has been found to influence the secretion and function of exosomes in various types of cancer. This review summarizes the physiological mechanism of hypoxia regulating exosome secretion, and discusses the involvement of hypoxic exosomes in cancer progression and immune escape processes, as well as the potential for targeting hypoxia-induced exosomes in cancer therapy strategies.

JOURNAL OF CANCER (2022)

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Review Neurosciences

Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology

S. J. Kierans et al.

Summary: Under hypoxic conditions, eukaryotic cells can shift metabolism towards glycolysis to maintain ATP levels, a process regulated by HIF-1 alpha. This metabolic switch is crucial for cellular survival during acute hypoxic stress and has implications for cancer cell survival and growth. Understanding the mechanisms central to this reprogramming is important for both physiological and pathophysiological processes.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Article Medicine, Research & Experimental

The impact of non-coding RNAs on macrophage polarization

Soudeh Ghafouri-Fard et al.

Summary: Macrophage polarization is a process where macrophages respond to external stimuli to acquire unique functional features, regulated by various miRNAs and lncRNAs. This process holds significance in many human disorders, particularly in immune disorders and cancer.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Rheumatology

Toll-like receptor signalling in B cells during systemic lupus erythematosus

Simon Fillatreau et al.

Summary: Loss of B cell tolerance to autoantigens in systemic lupus erythematosus (SLE) is driven by TLR7, whereas TLR9 appears to protect against SLE by limiting the stimulatory activity of TLR7. The unique features of Toll-like receptor signaling in B cells implicate it as a therapeutic target in SLE.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Review Cell & Tissue Engineering

Advances in mesenchymal stem cell exosomes: a review

Yaya Tang et al.

Summary: Stem cells are valuable in regenerative medicine and disease treatment, but face challenges such as storage limitations and cell senescence. Exosomes, as an alternative, have similar effects to stem cells and offer advantages such as targeted delivery, low immunogenicity, and high repairability.

STEM CELL RESEARCH & THERAPY (2021)

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Review Chemistry, Multidisciplinary

Promotion or inhibition of extracellular vesicle release: Emerging therapeutic opportunities

Yujia Hao et al.

Summary: Extracellular vesicles (EVs) are important vehicles for intercellular communication, with different physiological and pathological effects, and can be used as biological therapeutic agents. In some cases, the release of EVs can exacerbate disease progression, while inhibition may delay disease development.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Biochemistry & Molecular Biology

How Macrophages Become Transcriptionally Dysregulated: A Hidden Impact of Antitumor Therapy

Galina F. Medvedeva et al.

Summary: Tumor-associated macrophages (TAMs) are essential components of the tumor microenvironment, and their function is closely related to transcription factors such as STAT1, NF-kappa B, IRF, which affect tumor adaptation and resistance to radio- and chemotherapy, serving as important biomarkers for theranostics.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

Dan-in Jang et al.

Summary: TNF-α was originally identified as a factor causing tumor necrosis but has also been recognized as a pathological component of autoimmune diseases. Its signaling pathways play important roles in cellular responses, and inappropriate activation can lead to chronic inflammation and autoimmune diseases. TNF-α inhibitors have been developed as effective therapeutic tools for various autoimmune diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus

Hisato Iriki et al.

Summary: The study analyzed peripheral tolerance using the Dsg3 antigen and found that Treg-mediated peripheral deletion of autoreactive T cells is a key mechanism to avoid undesired autoimmunity, which is dependent on the OX40 signaling pathway.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Chemistry, Multidisciplinary

Nanoemulsions Target to Ectopic Lymphoids in Inflamed Joints to Restore Immune Tolerance in Rheumatoid Arthritis

Chenglong Li et al.

Summary: This study developed an engineered nanoemulsion for targeted co-delivery of self-antigens and an immunomodulator to inflamed joints in rheumatoid arthritis. The nanoemulsion showed satisfactory accumulation in the inflamed paws and provided enhanced anti-inflammatory effects in various experimental murine models of RA, offering a promising targeting strategy for immune tolerance induction in RA treatment.

NANO LETTERS (2021)

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Article Medicine, Research & Experimental

MicroRNA-23a-5p regulates cell proliferation, migration and inflammation of TNF-α-stimulated human fibroblast-like MH7A synoviocytes by targeting TLR4 in rheumatoid arthritis

Xiao Bao et al.

Summary: The expression of miR-23a-5p was significantly downregulated in the plasma of patients with RA and MH7A cells. Overexpression of miR-23a-5p inhibited TNF-α-induced cell proliferation, migration, and inflammatory factor production, while reversing decreases in cell apoptosis. MiR-23a-5p targeted TLR4 to inhibit the TLR4/NF-κB signaling pathway in TNF-α-treated MH7A cells.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Review Cell Biology

The exosome journey: from biogenesis to uptake and intracellular signalling

Sonam Gurung et al.

Summary: Exosomes have vast potential in clinical applications, and understanding their biology is crucial. The processes of exosome biogenesis, transport, and uptake involve numerous influencing factors.

CELL COMMUNICATION AND SIGNALING (2021)

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Article Pharmacology & Pharmacy

Effects of Hsp90 inhibitor on the RIP1-RIP3-MLKL pathway during the development of heart failure in mice

Tetsuro Marunouchi et al.

Summary: Necroptosis is a programmed form of cell death regulated by necroptosis-regulating proteins. Inhibition of Hsp90 reverses the increases in RIP1, RIP3, and MLKL in failing hearts, attenuating necrotic cell death and preserving cardiac functions. The findings suggest that targeting Hsp90 could be a new therapeutic strategy for chronic heart failure.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Immunology

Thymic B Cells as a New Player in the Type 1 Diabetes Response

Richard B. Greaves et al.

Summary: Type 1 diabetes is a result of sustained autoreactive T and B cell response towards insulin-producing beta cells in the islets of Langerhans. Among the many investigations addressing genetic or cellular changes related to central tolerance, thymic B cells have emerged as a new cellular player with a significant impact on the deletion of autoreactive T cells during their development. These thymic B cells can expand in T1D and other autoimmune conditions, leading to the secretion of autoantibodies that bind selective mTECs and induce their death.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity

Justine Castaneda et al.

Summary: The thymus harbors two distinct populations of B cells, medullary B cells and perivascular B cells, which play diverse roles in central tolerance and autoimmune diseases, with different origins and functions.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

miR-223: An Immune Regulator in Infectious Disorders

Shun Yuan et al.

Summary: miR-223 is a crucial microRNA that plays important regulatory roles in the immune response, with abnormal expression associated with various infectious diseases such as viral hepatitis, HIV-1, and tuberculosis. The understanding of miR-223 physiopathology and its molecular mechanism in regulating immune responses to infectious diseases could lead to targeted diagnosis and treatment strategies.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Toxicology

Emerging role of exosomes in arterial and renal calcification

Shumaila Bano et al.

Summary: Exosomes are small vesicles released by various cells participating in cell-to-cell communication. They can either inhibit or promote calcification within the cardiovascular system. Rich in proteins, nucleic acids, and lipids, exosomes are increasingly recognized as diagnostic biomarkers for diseases including kidney and liver diseases, as well as various cancers. These vesicles derived from stem cells also play a role in cardiovascular diseases.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

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Review Biochemistry & Molecular Biology

miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma

Mai-Huong Thi Nguyen et al.

Summary: Immune checkpoint inhibitors show promise in cancer treatment, but resistance in melanoma patients hinders their effectiveness. Recent studies explore the role of miRNAs in immune response and tumor microenvironment, suggesting their potential as key players in immunotherapy.

BIOMOLECULES (2021)

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Editorial Material Microbiology

Recent Advances in Unveiling the Role of Beta-Herpesviruses in Autoimmune Diseases

Maria Cristina Arcangeletti et al.

MICROORGANISMS (2021)

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Review Cell Biology

MicroRNA in extracellular vesicles regulates inflammation through macrophages under hypoxia

Ye Li et al.

Summary: EV-miRNAs regulate the polarization phenotype of macrophages under hypoxia, promoting the release of inflammation-related cytokines through various signaling pathways, ultimately affecting inflammation development. The biogenesis and secretion of EVs can be affected by a hypoxic environment, with cargoes participating in various physiological and pathological processes. MicroRNAs in EVs play a role in transcriptional regulation during hypoxia-induced inflammation, while macrophage polarization is closely linked to miRNAs and influences the inflammatory state.

CELL DEATH DISCOVERY (2021)

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Review Cardiac & Cardiovascular Systems

Mechanisms of Action of MiRNAs and LncRNAs in Extracellular Vesicle in Atherosclerosis

Hui Xu et al.

Summary: Atherosclerosis is a complex chronic inflammatory disease involving multiple types of cells, with extracellular vesicles containing miRNAs and lncRNAs playing a crucial role in disease progression. EVs not only contribute to intercellular communication but also have the potential to serve as diagnostic biomarkers and therapeutic targets for atherosclerosis.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Immunology

Systemic Proteomic Analysis Reveals Distinct Exosomal Protein Profiles in Rheumatoid Arthritis

Qiu Qin et al.

Summary: The study identified exosomal candidate proteins in the pathogenesis of Rheumatoid Arthritis (RA) among which 32 were upregulated and 5 were downregulated. These proteins interacted with each other and were mainly involved in inflammatory-related pathways, suggesting their role in mediating the onset of RA.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

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Review Oncology

Tetraspanins: Novel Molecular Regulators of Gastric Cancer

Yue Deng et al.

Summary: Tetraspanins play diverse roles in the progression of gastric cancer, including promoting or inhibiting cell proliferation and invasion, regulating cell motility, and impacting lymph node metastasis. They also have significant clinical implications in therapeutic targeting, drug resistance development, and prognosis prediction for gastric cancer.

FRONTIERS IN ONCOLOGY (2021)

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Review Microbiology

Effect of Coxsackievirus B4 Infection on the Thymus: Elucidating Its Role in the Pathogenesis of Type 1 Diabetes

Abdulaziz Alhazmi et al.

Summary: Viral infections, especially CVB4 infection, can disrupt thymic functions and may play a role in the pathogenesis of type 1 diabetes (T1D) by affecting thymic cells and functions.

MICROORGANISMS (2021)

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Article Oncology

TNF-α-stimulated nucleus pulposus cells induce cell apoptosis through the release of exosomal miR-16 targeting IGF-1 and IGF-1R in rats

Qi-Chen Zhang et al.

Summary: This study found that exosomes released under inflammatory conditions can induce apoptosis in normal nucleus pulposus cells through the regulation of miR-16, which represses IGF-1 expression and affects the IGF-1/IGF-1R pathway, leading to cell apoptosis.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Review Immunology

Autoantibodies in neurological disease

Harald Pruess

Summary: The realization of the impact of autoantibodies on brain function has led to a paradigm shift in neurological diseases, providing new insights into central nervous system autoimmunity and driving clinical and experimental research. While specific autoantibodies have been identified, the search for more continues with promising results.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Regulation of exosome production and cargo sorting

Hong Wei et al.

Summary: Cellular communication through the exchange of biological information, mainly in the form of proteins and RNAs, is mediated by extracellular vesicles like exosomes. Understanding the molecular mechanisms of exosome secretion and cargo sorting is crucial for shedding light on their physiological and pathological functions, as well as for exploring potential therapeutic opportunities in clinical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

miR-21-5p Under-Expression in Patients with Obstructive Sleep Apnea Modulates Intermittent Hypoxia with Re-Oxygenation-Induced-Cell Apoptosis and Cytotoxicity by Targeting Pro-Inflammatory TNF-alpha-TLR4 Signaling

Yung-Che Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia

Nina E. Murugina et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Review Cell Biology

Life in the lumen: The multivesicular endosome

Jean Gruenberg

TRAFFIC (2020)

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Review Immunology

New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages

Ana Batista-Gonzalez et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Oncology

Hypoxia in tumor microenvironment regulates exosome biogenesis: Molecular mechanisms and translational opportunities

Ashish Kumar et al.

CANCER LETTERS (2020)

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Review Cell Biology

The Role of HIF in Immunity and Inflammation

Anne F. McGettrick et al.

CELL METABOLISM (2020)

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Review Biochemistry & Molecular Biology

Tetraspanins, More than Markers of Extracellular Vesicles in Reproduction

Jana Jankovicova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Dermatology

Imiquimod-induced dermatitis impairs thymic tolerance of autoreactive CD4+ T cells to desmoglein 3

Hisato Iriki et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2020)

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Review Oncology

Dexosomes as a cell-free vaccine for cancer immunotherapy

Sepideh Nikfarjam et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Medicine, Research & Experimental

Hypoxic exosomes orchestrate tumorigenesis: molecular mechanisms and therapeutic implications

Reza Jafari et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

Exosomal Transfer of Macrophage-Derived miR-223 Confers Doxorubicin Resistance in Gastric Cancer

Huijie Gao et al.

ONCOTARGETS AND THERAPY (2020)

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Review Immunology

Molecular Mimicry and Uveitis

Gerhild Wildner et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Thematic Review Series: Exosomes and Microvesicles: Lipids as Key Components of their Biogenesis and Functions Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

Tore Skotland et al.

JOURNAL OF LIPID RESEARCH (2019)

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Article Cardiac & Cardiovascular Systems

Mesenchymal stromal cell-derived exosomes attenuatemyocardial ischaemia-reperfusion injury throughmiR-182-regulated macrophage polarization

Jinxuan Zhao et al.

CARDIOVASCULAR RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Exosomes: biogenesis, biologic function and clinical potential

Yuan Zhang et al.

CELL AND BIOSCIENCE (2019)

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Review Biochemistry & Molecular Biology

Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

Doralicia Casares et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Immunology

MicroRNAs as Molecular Switches in Macrophage Activation

Graziella Curtale et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Cell Biology

CD28 Autonomous Signaling Up-Regulates C-Myc Expression and Promotes Glycolysis Enabling Inflammatory T Cell Responses in Multiple Sclerosis

Martina Kunkl et al.

CELLS (2019)

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Review Oncology

Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment

Xinyu Tian et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Medicine, Research & Experimental

Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment

Yoda Yaghoubi et al.

LIFE SCIENCES (2019)

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Article Multidisciplinary Sciences

UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity

Olivia Majer et al.

NATURE (2019)

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Review Oncology

Exosomes: Versatile Nano Mediators of Immune Regulation

Qi Li et al.

CANCERS (2019)

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Article Multidisciplinary Sciences

Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications

Girijesh Kumar Patel et al.

SCIENTIFIC REPORTS (2019)

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Review Immunology

Roles of Exosomes Derived From Immune Cells in Cardiovascular Diseases

Runda Wu et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Annexins-Coordinators of Cholesterol Homeostasis in Endocytic Pathways

Carles Rentero et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Immunology

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

Marthe F. S. Lindenbergh et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)

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Article Immunology

miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis

Zhiqiang Pan et al.

JOURNAL OF NEUROINFLAMMATION (2018)

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Review Oncology

Exosomes as a liquid biopsy for lung cancer

Shaohua Cui et al.

LUNG CANCER (2018)

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Article Multidisciplinary Sciences

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors

Dongshi Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Neurosciences

Applications of stem cell-derived exosomes in tissue engineering and neurological diseases

Baichuan Sun et al.

REVIEWS IN THE NEUROSCIENCES (2018)

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Review Immunology

T-cell cross-reactivity may explain the large variation in how cancer patients respond to checkpoint inhibitors

Mouldy Sioud

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2018)

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Review Immunology

Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancer

Furong Zeng et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

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Review Immunology

Exosomes and Immune Response in Cancer: Friends or Foes?

Francisco M. Barros et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Transcriptional Regulation of Macrophages Polarization by MicroRNAs

Heng Li et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment

Alireza Tahamtan et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Biochemistry & Molecular Biology

Hypoxia, Metabolism and Immune Cell Function

Ewelina Krzywinska et al.

BIOMEDICINES (2018)

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Review Biochemistry & Molecular Biology

Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer

Georgios S. Markopoulos et al.

BIOMEDICINES (2018)

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Review Biochemistry & Molecular Biology

Current knowledge on exosome biogenesis and release

Nina Pettersen Hessvik et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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Article Immunology

The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis

Takashi Tomiyama et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2017)

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Article Allergy

Beyond Genetics: What Causes Type 1 Diabetes

Zhen Wang et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2017)

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Review Oncology

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