4.7 Review

The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Psychology, Clinical

Increased prevalence of metabolic syndrome in Veterans with PTSD untreated with antipsychotic medications

Barton W. Palmer et al.

Summary: Post-Traumatic Stress Disorder (PTSD) is associated with an increased risk of metabolic syndrome (MetS), independent of antipsychotic medication. Attention should be given to managing metabolic risk factors in patients with PTSD.

INTERNATIONAL JOURNAL OF MENTAL HEALTH (2023)

Review Cell Biology

Emerging rejuvenation strategies-Reducing the biological age

Bohan Zhang et al.

Summary: There are interventions proposed to reverse aging rather than just slow it down, but the criteria for achieving rejuvenation are still controversial. A key prerequisite for a rejuvenation intervention is a significant reduction in biological age, which can be assessed by biomarkers such as epigenetic clocks.

AGING CELL (2022)

Article Biochemistry & Molecular Biology

Circadian Control of Mitochondria in Reactive Oxygen Species Homeostasis

Volha Mezhnina et al.

Summary: This article discusses the role of the circadian clock and mitochondrial rhythms in maintaining ROS homeostasis. The circadian clock regulates mitochondrial functions, including nutrient flux, oxidation, antioxidant defense, and mitochondrial dynamics. Understanding the molecular mechanisms of circadian control of mitochondrial functions is essential in preventing metabolic diseases and delaying aging.

ANTIOXIDANTS & REDOX SIGNALING (2022)

Review Endocrinology & Metabolism

The fatter, the better in old age: the current understanding of a difficult relationship

Guilherme Wesley Peixoto da Fonseca et al.

Summary: The protective effect of obesity on mortality in older adults is still controversial. Recent studies have shown a J or U-shaped relationship between BMI and mortality, with an optimal range between 22 and 37 kg/m(2). BMI has limitations in determining body composition and fat distribution. Further research should consider other factors such as skeletal muscle mass and muscle function. To promote healthy aging, excessive fat mass should be avoided and skeletal muscle mass and muscle function should be maintained or improved.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2022)

Review Biochemistry & Molecular Biology

Deranged Myocardial Fatty Acid Metabolism in Heart Failure

Tsunehisa Yamamoto et al.

Summary: The heart requires fatty acids for its activity, and regulation of fatty acid metabolism has significant impacts on the structure and function of the heart.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells

Zhengyin Gao et al.

Summary: This review focuses on the role of neuropeptide/GPCR system modulation of cAMP/EPACs pathways in cancers, discussing the potential mechanisms and implications in cancer cell proliferation, migration, and metastasis.

MOLECULES (2022)

Review Endocrinology & Metabolism

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Joao A. Amorim et al.

Summary: Organismal ageing leads to cellular function loss and systemic deterioration, making individuals more vulnerable to death. Mitochondria play a crucial role not only as energy suppliers but also in the development of ageing-associated diseases. Evidence suggests that ageing and age-related diseases are closely related to imbalances in energy supply and demand, which can be alleviated through various interventions.

NATURE REVIEWS ENDOCRINOLOGY (2022)

Review Behavioral Sciences

Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer's Disease

Brandon Emanuel Leon et al.

Summary: Mitochondria play a crucial role in various cellular functions and are essential for maintaining energy homeostasis in neurons. Chronic and heavy alcohol use can accelerate brain aging and increase the risk of dementia, especially Alzheimer's disease. Alcohol-induced mitochondrial dysfunction is associated with neuroimmune responses, including pro-inflammatory cytokines. This review focuses on how alcohol affects the aging process and exacerbates Alzheimer's disease by impairing mitochondrial function.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2022)

Article Biochemistry & Molecular Biology

Peroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape

Barbora Salovska et al.

Summary: This study reveals a novel role of PRDX6 in senescent cell viability and the development of senescence-associated secretory phenotype (SASP). It highlights the potential of PRDX6 as a drug target for senolytic or senomodulatory therapy.

REDOX BIOLOGY (2022)

Review Biochemistry & Molecular Biology

The Role of NRF2 in Obesity-Associated Cardiovascular Risk Factors

Jorge Gutierrez-Cuevas et al.

Summary: Obesity is associated with increased risk for cardiovascular diseases, leading to atherosclerosis and cardiac dysfunction. NRF2 plays a crucial role in oxidative stress and the pathogenesis of cardiovascular diseases.

ANTIOXIDANTS (2022)

Article Biochemistry & Molecular Biology

Adipose tissue microenvironments during aging: Effects on stimulated lipolysis

Christina D. Camell

Summary: Adipose tissue plays a crucial role in nutrient sensing, energy storage, and metabolic health. Impairment of adipose tissue homeostasis during aging leads to metabolic disease. Aging is associated with dysfunction in the immune, nervous, and lymphatic systems, resulting in reduced ability to stimulate lipolysis.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2022)

Review Biochemistry & Molecular Biology

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function

Yihang Zhao et al.

Summary: This review focuses on the mechanisms by which intermittent fasting (IF) improves mitochondrial function in brain aging and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. IF activates adaptive cellular stress responses and signaling pathways, enhancing mitochondrial function by promoting energy metabolism and reducing oxidant production.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Article Urology & Nephrology

Progression of established non-diabetic chronic kidney disease is halted by metformin treatment in rats

Raphaelle Corremans et al.

Summary: This study evaluated the therapeutic efficacy of metformin and canagliflozin in slowing the progression of non-diabetic CKD. Metformin showed protective effects against kidney impairment, while canagliflozin did not. Proteomic analysis revealed that metformin's kidney-protective effect was associated with the activation of the Hippo signaling pathway.

KIDNEY INTERNATIONAL (2022)

Article Cell Biology

The Role of Mitochondria in Human Fertility and Early Embryo Development: What Can We Learn for Clinical Application of Assessing and Improving Mitochondrial DNA?

Amira Podolak et al.

Summary: Mitochondria, known as 'the powerhouses of the cell', play a crucial role in cellular energy production and are essential for successful fertilisation and embryo development. Mitochondrial DNA, which is inherited from the mother, is important for providing sufficient energy for the developing embryo. Mutations or deletions in mitochondrial DNA may affect human fertility and early embryogenesis. The field of mitochondrial research has great potential for clinical application, but there are still many questions and uncertainties in assessing and improving DNA quantity and function in reproductive medicine.
Review Psychology, Clinical

The role of intraindividual cognitive variability in posttraumatic stress syndromes and cognitive aging: a literature search and proposed research agenda

Lauren A. Rutter et al.

Summary: Recent studies suggest that intraindividual cognitive variability may predict future cognitive impairment, including premature cognitive aging, and is significantly associated with posttraumatic stress disorder (PTSD) symptoms. Therefore, intraindividual reaction time (RT) variability may serve as a common pathological indicator for trauma-related dementia risk.

INTERNATIONAL PSYCHOGERIATRICS (2021)

Article Biochemistry & Molecular Biology

A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance

Yuan Liu et al.

Summary: A newly discovered compound, BC1618, inhibits the degradation of phosphorylated Ampk alpha by targeting the protein Fbxo48, thereby enhancing Ampk biological activity and promoting mitochondrial fission, autophagy, and improved insulin sensitivity in obese mice. This study reveals a novel pathway for regulating Ampk activity.

NATURE CHEMICAL BIOLOGY (2021)

Article Endocrinology & Metabolism

Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression: Implications for Estradiol Action

Camila de Avila et al.

Summary: Food intake varies during the ovarian hormone/estrous cycle in humans and rodents, mediated mainly by estradiol. The RLN3/RXFP3 system is modulated by the estrous cycle, suggesting its involvement in food intake fluctuations observed in female rats. Further studies are needed to elucidate the cellular and molecular mechanisms of estradiol signaling.

NEUROENDOCRINOLOGY (2021)

Article Biochemistry & Molecular Biology

The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

Eugenio Barone et al.

Summary: The article discusses the potential relationship between type 2 diabetes and Alzheimer's disease, highlighting the roles of oxidative stress, insulin resistance, and AMPK dysfunction in neurodegenerative disorders.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Pharmacology & Pharmacy

Aging-related modifications to G protein-coupled receptor signaling diversity

Jaana van Gastel et al.

Summary: Aging is a complex molecular process that affects almost all tissue systems in humans and is the primary risk factor for neurodegenerative disorders, cardiovascular disease, and Type 2 diabetes. With the current focus on GPCR-targeted therapeutics dominating the pharmacopeia, searching for effective anti-aging treatments in this area may be beneficial. A nuanced understanding of GPCR signaling diversity could lead to the development of therapeutics with selective signaling activities to impact the complex aberrations of the aging process.

PHARMACOLOGY & THERAPEUTICS (2021)

Review Biochemistry & Molecular Biology

GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease

Hanne Leysen et al.

Summary: GPCRs are highly effective therapeutic targets for a wide range of diseases. Their molecular diversity is closely linked to changes in tissue complexity and compartmentalization, allowing them to intervene in multiple disease mechanisms at a systemic level. The formation of stable multiprotein GPCR superstructures, known as receptorsomes, at both the cell surface membrane and intracellular domain, plays a crucial role in regulating long-term GPCR activities associated with various cellular functions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Physiology

Adipose tissue macrophages in aging-associated adipose tissue function

Bangchao Lu et al.

Summary: In inflammaging, chronic low-grade inflammation is a characteristic of aging, which is also associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) play a significant role in obesity-related inflammation and insulin resistance. Research on the changes and functions of ATMs in aging and aging-related diseases is ongoing, with a focus on potential therapeutic targets for prevention and treatment.

JOURNAL OF PHYSIOLOGICAL SCIENCES (2021)

Review Psychiatry

Ageing with schizophrenia: an update

Haley Solomon et al.

Summary: The number of older adults with schizophrenia is increasing rapidly, with significant variability in symptom severity and outcomes. Antipsychotics are essential in treatment, while nonpharmacologic psychosocial interventions also play a critical role in adjunctive treatment.

CURRENT OPINION IN PSYCHIATRY (2021)

Review Cardiac & Cardiovascular Systems

Metabolism and Chronic Inflammation: The Links Between Chronic Heart Failure and Comorbidities

Zhiwei Li et al.

Summary: Heart failure patients often have multiple comorbidities, leading to poor prognosis. The reciprocal correlation between comorbidities and HF suggests common causes and biological mechanisms. Metabolism and inflammation play a vital role in the pathophysiological processes, providing opportunities for common therapeutic strategies for HF and comorbidities.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Geriatrics & Gerontology

Oxidative stress, antioxidants, hormesis and calorie restriction: The current perspective in the biology of aging

Mohammad Murtaza Mehdi et al.

Summary: Aging is defined as the result of oxidative stress affecting cells, leading to cellular dysfunction and slowing down of the system. Slowing down the aging process involves reducing the rate of cellular oxidative damage, which is related to genetic factors, lifestyle, and diet. Understanding aging theories and molecular damage caused by oxidative stress is crucial for anti-aging strategies.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2021)

Article Geriatrics & Gerontology

Aging, obesity, sarcopenia and the effect of diet and exercise intervention

Georgia Colleluori et al.

Summary: The increasing number of older adults and obesity prevalence highlights the importance of interventions focusing on diet and exercise. Diet-induced weight loss may exacerbate age-related sarcopenia and frailty. Successful strategies to preserve lean and bone mass while reducing fat mass are critical to address physical and metabolic complications related to aging and obesity.

EXPERIMENTAL GERONTOLOGY (2021)

Article Anatomy & Morphology

Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat

Cristina Garcia-Diaz et al.

Summary: The study focused on the neurophysiological interactions between the hippocampus, entorhinal cortex, and the NI/relaxin-3 innervation in the parahippocampal cortex. Results demonstrate the significant functional role of the NI/relaxin-3-parahippocampal innervation on processes related to memory, spatial navigation, and contextual analysis.

FRONTIERS IN NEUROANATOMY (2021)

Article Health Care Sciences & Services

Knowledge, Attitudes, and Screening for Obstructive Sleep Apnea and Diabetes Mellitus among War Veterans Seeking Treatment of Posttraumatic Stress Disorder

Ante Mayer et al.

Summary: Posttraumatic stress disorder (PTSD) patients are at higher risk for cardiovascular diseases (CVD), especially with the association between obstructive sleep apnea (OSA) and diabetes mellitus. In this study, higher levels of PTSD symptoms in veterans were associated with a higher prevalence of OSA.

HEALTHCARE (2021)

Article Multidisciplinary Sciences

Relaxin peptides reduce cellular damage in cultured brain slices exposed to transient oxygen-glucose deprivation: an effect mediated by nitric oxide

Nicholas P. DeAdder et al.

Summary: The study showed that H2 and H3 relaxin treatments have a protective effect on cell death caused by oxygen and glucose deprivation, with the effect of H3 relaxin being partially attenuated by L-NIL, and antagonism of RXFP3 affecting the action of H3 relaxin.

FACETS (2021)

Article Geriatrics & Gerontology

Mechanistic target of rapamycin signaling in mouse models of accelerated aging

Jin Young Lee et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2020)

Review Psychiatry

Effect of age on the relative efficacy of clozapine in schizophrenia

R. Jones et al.

ACTA PSYCHIATRICA SCANDINAVICA (2020)

Review Cell Biology

Ageing, age-related diseases and oxidative stress: What to do next?

Jiao Luo et al.

AGEING RESEARCH REVIEWS (2020)

Review Cell Biology

The ageing epigenome and its rejuvenation

Weiqi Zhang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Geriatrics & Gerontology

Epigenetic changes during ageing and their underlying mechanisms

Deisi L. Braga et al.

BIOGERONTOLOGY (2020)

Review Endocrinology & Metabolism

Molecular basis of ageing in chronic metabolic diseases

R. Spinelli et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2020)

Review Biochemistry & Molecular Biology

Beyond structure: emerging approaches to study GPCR dynamics

Anastasiia Gusach et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Becoming Stressed: Does the Age Matter? Reviewing the Neurobiological and Socio-Affective Effects of Stress throughout the Lifespan

Aroa Manas-Ojeda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Respiratory System

The ageing lung under stress

Martina Korfei et al.

EUROPEAN RESPIRATORY REVIEW (2020)

Article Multidisciplinary Sciences

Metal ions shape alpha-synuclein

Rani Moons et al.

SCIENTIFIC REPORTS (2020)

Article Multidisciplinary Sciences

Reprogramming to recover youthful epigenetic information and restore vision

Yuancheng Lu et al.

NATURE (2020)

Review Cell Biology

Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction

Sanne van der Rijt et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Editorial Material Cell Biology

Aging and ischemic stroke

Mohammed Yousufuddin

AGING-US (2019)

Article Chemistry, Medicinal

Discovery of a small molecule RXFP3/4 agonist that increases food intake in rats upon acute central administration

Brian DeChristopher et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Article Urology & Nephrology

Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance

Britt Opdebeeck et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

Article Cell Biology

Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories

Jaana van Gastel et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2019)

Review Biochemistry & Molecular Biology

G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence

Paula Santos-Otte et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2019)

Article Multidisciplinary Sciences

A single combination gene therapy treats multiple age-related diseases

Noah Davidsohn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Endocrinology & Metabolism

Pathophysiological roles of nutrient-sensing mechanisms in diabetes and its complications

Shinji Kume

DIABETOLOGY INTERNATIONAL (2019)

Review Biotechnology & Applied Microbiology

DNA methylation aging clocks: challenges and recommendations

Christopher G. Bell et al.

GENOME BIOLOGY (2019)

Review Cell Biology

Pathways of cellular proteostasis in aging and disease

Courtney L. Klaips et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Toxicology

Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic

Donna L. Mendrick et al.

TOXICOLOGICAL SCIENCES (2018)

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2018 Update A Report From the American Heart Association

Emelia J. Benjamin et al.

CIRCULATION (2018)

Review Neurosciences

Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling

Francisco E. Olucha-Bordonau et al.

CNS NEUROSCIENCE & THERAPEUTICS (2018)

Editorial Material Cell Biology

Telomerase can't handle the stress

Susan Smith

GENES & DEVELOPMENT (2018)

Review Geriatrics & Gerontology

Oxidative stress, aging, and diseases

Ilaria Liguori et al.

CLINICAL INTERVENTIONS IN AGING (2018)

Review Biochemistry & Molecular Biology

G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes

Hanne Leysen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Geriatrics & Gerontology

Emerging Anti-Aging Strategies - Scientific Basis and Efficacy

Ashok K. Shetty et al.

AGING AND DISEASE (2018)

Review Psychiatry

Effects of drinking on late-life brain and cognition

Anya Topiwala et al.

EVIDENCE-BASED MENTAL HEALTH (2018)

Review Pharmacology & Pharmacy

Sex-specific effects of relaxin-3 on food intake and body weight gain

Juliane Calvez et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Toward an understanding of the protein interaction network of the human liver

Jian Wang et al.

Molecular Systems Biology (2017)

Article Genetics & Heredity

Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia

Sheng-An Lee et al.

BMC MEDICAL GENOMICS (2016)

Article Neurosciences

Increased alcohol consumption in relaxin-3 deficient male mice

Takahira Shirahase et al.

NEUROSCIENCE LETTERS (2016)

Article Physics, Multidisciplinary

Measurement of the Inelastic Proton-Proton Cross Section at √s=13 TeV with the ATLAS Detector at the LHC

M. Aaboud et al.

PHYSICAL REVIEW LETTERS (2016)

Article Endocrinology & Metabolism

GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging

Bronwen Martin et al.

FRONTIERS IN ENDOCRINOLOGY (2016)

Article Biochemistry & Molecular Biology

Antiviral Activity of a Novel Compound CW-33 against Japanese Encephalitis Virus through Inhibiting Intracellular Calcium Overload

Su-Hua Huang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Endocrinology & Metabolism

Relaxin Peptide Hormones Are Protective During the Early Stages of Ischemic Stroke in Male Rats

Lindsay H. Bergeron et al.

ENDOCRINOLOGY (2015)

Article Biochemistry & Molecular Biology

Nuclear GIT2 Is an ATM Substrate and Promotes DNA Repair

Daoyuan Lu et al.

MOLECULAR AND CELLULAR BIOLOGY (2015)

Article Neurosciences

A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits

Matthew B. Pomrenze et al.

FRONTIERS IN NEUROSCIENCE (2015)

Article Multidisciplinary Sciences

Relaxin-3 Receptor (RXFP3) Signalling Mediates Stress-Related Alcohol Preference in Mice

Andrew W. Walker et al.

PLOS ONE (2015)

Review Endocrinology & Metabolism

The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling

Yun Chau Long et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)

Article Cell Biology

GPCR signaling along the endocytic pathway

Roshanak Irannejad et al.

CURRENT OPINION IN CELL BIOLOGY (2014)

Article Pharmacology & Pharmacy

Increase of Oxidation and Inflammation in Nervous and Immune Systems with Aging and Anxiety

Carmen Vida et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Review Biochemistry & Molecular Biology

G Protein-Coupled Receptors: What a Difference a 'Partner' Makes

Benoit T. Roux et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Endocrinology & Metabolism

Relaxin-3 stimulates the neuro-endocrine stress axis via corticotrophin-releasing hormone

B. M. McGowan et al.

JOURNAL OF ENDOCRINOLOGY (2014)

Article Biochemical Research Methods

Pharmacophore model of the quercetin binding site of the SIRT6 protein

S. Ravichandran et al.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2014)

Review Cell Biology

Cellular senescence: from physiology to pathology

Daniel Munoz-Espin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Endocrinology & Metabolism

Regulation of expression of relaxin-3 and its receptor RXFP3 in the brain of diet-induced obese rats

Christaphe Lenglos et al.

NEUROPEPTIDES (2014)

Article Biochemistry & Molecular Biology

The Expression of Relaxin-3 in Adipose Tissue and its Effects on Adipogenesis

Hiroyuki Yamamoto et al.

PROTEIN AND PEPTIDE LETTERS (2014)

Article Multidisciplinary Sciences

Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

Chi Kwan Tsang et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

Ricki J. Colman et al.

NATURE COMMUNICATIONS (2014)

Article Biotechnology & Applied Microbiology

Epigenetic Silencing of CXCR4 Promotes Loss of Cell Adhesion in Cervical Cancer

Suresh Singh Yadav et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Review Endocrinology & Metabolism

Systems-level G protein-coupled receptor therapy across a neurodegenerative continuum by the GLP-1 receptor system

Jonathan Janssens et al.

FRONTIERS IN ENDOCRINOLOGY (2014)

Article Biochemistry & Molecular Biology

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

Mohammed Akhter Hossain et al.

AMINO ACIDS (2013)

Article Behavioral Sciences

Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat

Philip J. Ryan et al.

BEHAVIOURAL BRAIN RESEARCH (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Review Biochemistry & Molecular Biology

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

Antero Salminen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Endocrinology & Metabolism

Expression of Type 2 Orexin Receptor in Human Endometrium and Its Epigenetic Silencing in Endometrial Cancer

P. Dehan et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Endocrinology & Metabolism

β-Arrestin-Selective G Protein-Coupled Receptor Agonists Engender Unique Biological Efficacy in Vivo

Diane Gesty-Palmer et al.

MOLECULAR ENDOCRINOLOGY (2013)

Article Multidisciplinary Sciences

Relaxin-3/RXFP3 system regulates alcohol-seeking

Philip J. Ryan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Endocrinology & Metabolism

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3

Ross A. D. Bathgate et al.

Frontiers in Endocrinology (2013)

Article Endocrinology & Metabolism

Relaxin-3/RXFP3 Signaling and Neuroendocrine Function – A Perspective on Extrinsic Hypothalamic Control

Despina E. Ganella et al.

Frontiers in Endocrinology (2013)

Article Clinical Neurology

Metabolic Dysfunction in Alzheimer's Disease and Related Neurodegenerative Disorders

Huan Cai et al.

CURRENT ALZHEIMER RESEARCH (2012)

Article Endocrinology & Metabolism

The Critical Role of Metabolic Pathways in Aging

Nir Barzilai et al.

DIABETES (2012)

Article Clinical Neurology

Relaxin polymorphisms associated with metabolic disturbance in patients treated with antipsychotics

Janet Munro et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2012)

Review Chemistry, Medicinal

Functional Signaling Biases in G Protein-Coupled Receptors: Game Theory and Receptor Dynamics

S. Maudsley et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Growth Inhibition by miR-519 via Multiple p21-Inducing Pathways

Kotb Abdelmohsen et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Endocrinology & Metabolism

Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions

Alexis M. Stranahan et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2012)

Article Biochemistry & Molecular Biology

H3 Relaxin Demonstrates Antifibrotic Properties via the RXFP1 Receptor

Mohammed Akhter Hossain et al.

BIOCHEMISTRY (2011)

Article Endocrinology & Metabolism

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells

Wook Kim et al.

DIABETES (2011)

Editorial Material Endocrinology & Metabolism

To Be or Not To Be-Obese

Stuart Maudsley et al.

ENDOCRINOLOGY (2011)

Review Biochemistry & Molecular Biology

Relaxin-3 systems in the brain-The first 10 years

Craig M. Smith et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2011)

Review Cell Biology

Regulation of GPCR signal networks via membrane trafficking

F. Jean-Alphonse et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

Review Developmental Biology

Relaxin family peptides in the male reproductive system-a critical appraisal

Richard Ivell et al.

MOLECULAR HUMAN REPRODUCTION (2011)

Article Cell Biology

ATM activation in the presence of oxidative stress

Zhi Guo et al.

CELL CYCLE (2010)

Review Biochemistry & Molecular Biology

Relaxin family peptide systems and the central nervous system

G. E. Callander et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

Article Neurosciences

Gonadotropin-Releasing Hormone Receptor System: Modulatory Role in Aging and Neurodegeneration

Liyun Wang et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2010)

Article Multidisciplinary Sciences

Minimal Peroxide Exposure of Neuronal Cells Induces Multifaceted Adaptive Responses

Wayne Chadwick et al.

PLOS ONE (2010)

Article Biochemistry & Molecular Biology

Relaxin Family Genes in Humans and Teleosts Bioinformatic Analyses and Expression of Three RLN Genes in Teleosts

Sergey Yegorov et al.

RELAXIN AND RELATED PEPTIDES: FIFTH INTERNATIONAL CONFERENCE (2009)

Article Biochemistry & Molecular Biology

Relaxin-3 and RXFP3 expression, and steroidogenic actions in the ovary of teleost fish

Brian C. Wilson et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2009)

Review Biochemistry & Molecular Biology

Pharmacomimetics of Exercise: Novel Approaches for Hippocampally-Targeted Neuroprotective Agents

A. M. Stranahan et al.

CURRENT MEDICINAL CHEMISTRY (2009)

Article Neurosciences

Anxiety-like behaviors in mice lacking GIT2

Robert Schmalzigaug et al.

NEUROSCIENCE LETTERS (2009)

Article Biochemistry & Molecular Biology

Regulation of P2X(7) gene transcription

Lingyin Zhou et al.

PURINERGIC SIGNALLING (2009)

Review Cell Biology

Caloric restriction: Impact upon pituitary function and reproduction

Bronwen Martin et al.

AGEING RESEARCH REVIEWS (2008)

Article Endocrinology & Metabolism

Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis

B. M. McGowan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)

Article Endocrinology & Metabolism

Dietary adherence and weight loss success among overweight women: results from the A TO Z weight loss study

S. Alhassan et al.

INTERNATIONAL JOURNAL OF OBESITY (2008)

Review Cell Biology

DNA double-strand breaks: A potential causative factor for mammalian aging?

Han Li et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2008)

Article Endocrinology & Metabolism

Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets

Jie Zhou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)

Review Clinical Neurology

G protein-coupled receptor signaling complexity in neuronal tissue: Implications for novel therapeutics

Stuart Maudsley et al.

CURRENT ALZHEIMER RESEARCH (2007)

Review Geriatrics & Gerontology

Hormesis and aging in Caenorhabditis elegans

James R. Cypser et al.

EXPERIMENTAL GERONTOLOGY (2006)

Article Endocrinology & Metabolism

Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats

B. M. McGowan et al.

REGULATORY PEPTIDES (2006)

Article Biochemistry & Molecular Biology

Chronic intracerebroventricular administration of relaxin-3 increases body weight in rats

T Hida et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2006)

Article Neurosciences

Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress

M Tanaka et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2005)

Article Biochemistry & Molecular Biology

Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors

AM Wilbanks et al.

BIOCHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Transcriptional profile of aging in C-elegans

J Lund et al.

CURRENT BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene -: Novel members of the relaxin peptide family

RAD Bathgate et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Multidisciplinary Sciences

Genetic pathways that regulate ageing in model organisms

L Guarente et al.

NATURE (2000)

Article Biochemistry & Molecular Biology

The GIT family of ADP-ribosylation factor GTPase-activating proteins - Functional diversity of GIT2 through alternative splicing

RT Premont et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)