☆ 4.7 Review

Opioidergic Signaling-A Neglected, Yet Potentially Important Player in Atopic Dermatitis

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Dermatology

Do epidermal keratinocytes have sensory and information processing systems?

Mitsuhiro Denda et al.

Summary: Keratinocytes were traditionally believed to only construct a protective barrier in the skin, but recent research has shown that they also have sensory systems capable of detecting environmental changes and expressing neurotransmitters and receptors. Activation of keratinocytes has been found to influence sensory perception in the brain, suggesting they may represent an early stage in brain development during vertebrate evolution.

EXPERIMENTAL DERMATOLOGY (2022)

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Article Dermatology

Topical κ-opioid receptor agonist asimadoline improves dermatitis in a canine model of atopic dermatitis

Rosanna Marsella et al.

Summary: This study demonstrated the efficacy of 1% topical kappa-opioid agonist in dogs with atopic dermatitis; however, a crossing of pruritus scores on Day 17 resulted in no significant effect on pruritus, and over time, the active ingredient showed decreasing efficacy after the first 3 weeks.

EXPERIMENTAL DERMATOLOGY (2022)

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Article Dermatology

Dupilumab for atopic dermatitis: a real-world Portuguese multicenter retrospective study

T. Torres et al.

Summary: Dupilumab, an IL-4 and IL-13 inhibitor, has been shown to be an effective and safe therapeutic option for the treatment of atopic dermatitis (AD). This study provides real-world data demonstrating its efficacy and safety in a nationwide cohort of AD patients.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

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Article Dermatology

Itch: Pathogenesis and treatment

Nishadh Sutaria et al.

Summary: Itch pathogenesis can be broadly characterized into histaminergic and nonhistaminergic pathways, with crosstalk between the immune and neural systems modulating itch transmission. Th2 cytokines are important mediators in itch pathogenesis.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Review Pharmacology & Pharmacy

Pruritus: A Sensory Symptom Generated in Cutaneous Immuno-Neuronal Crosstalk

Attila Gabor Szollosi et al.

Summary: Pruritus, or itch, is a common symptom associated with various skin and immune disorders. Despite significant progress in understanding the molecular mechanisms behind acute and chronic itch, there are still gaps in our knowledge, making the clinical management of pruritic conditions challenging. Recent research has highlighted the interactions between pruriceptive sensory neurons and different cutaneous cell types, particularly in inflammatory conditions, where these cells release mediators that excite the itch-sensing fibers. There is also bidirectional communication, with sensory neurons releasing mediators that maintain an inflamed and itchy tissue environment.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Allergy

New and emerging treatments for inflammatory itch

Stephen Erickson et al.

Summary: Recent therapeutic developments for chronic pruritus have focused on allergic and type 2 inflammatory pathways, targeting histamine, immunoglobulin E, and various cytokines. Advances in neuroimmunology have led to the identification of new therapeutic targets and the rapid development of cutting-edge clinical trials, yet chronic itch remains an area of significant unmet need.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

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Article Dermatology

MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway

Magda Babina et al.

Summary: Codeine activates dermal mast cells through MRGPRX2 as its dominant receptor, with activation displaying individual variability and being subject to desensitization. Codeine-induced activation of MRGPRX2 leads to rapid internalization and E3-arrestin activation, suggesting a potential mechanism for refractoriness. Pre-stimulation with MRGPRX2 agonists results in cross desensitization, indicating a possible strategy to prevent severe pseudoallergic reactions.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Review Dermatology

Substance use disorders and chronic itch

Zoe M. Lipman et al.

Summary: Chronic pruritus could be a dermatologic manifestation of an underlying substance use disorder, with research revealing similarities in neurologic mechanisms between addiction and chronic itch involving dopamine activation and opioid receptor imbalances. It is important to consider underlying substance use disorders in patients to effectively treat them.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Translational Neuroendocrinology of Human Skin: Concepts and Perspectives

Yuval Ramot et al.

Summary: Neurohormones play a vital role in human skin physiology and pathology, and their study can lead to novel dermatological therapies. Human skin and its appendages serve as accessible model systems for investigating non-classical neurohormone functions, highlighting the importance of interdisciplinary collaboration.

TRENDS IN MOLECULAR MEDICINE (2021)

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Article Pharmacology & Pharmacy

The TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators

Balazs Kelemen et al.

Summary: TRPM3 selectively mediates pain sensation but not itch sensation, making it a promising candidate for selectively targeting pain sensation.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Clinical Neurology

Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition

Zilong Wang et al.

Summary: The study demonstrates that intrathecal opioids can induce itching by acting on MOR on spinal inhibitory interneurons, resulting in disinhibition of the spinal itch circuit. In addition, spinal ablation of GRPR(+) neurons can reduce opioid-induced itch, while intrathecal NPY administration can suppress itch response.

BRAIN (2021)

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Review Biochemistry & Molecular Biology

Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism

Alexander Pilozzi et al.

Summary: Beta-endorphins are peptides with diverse effects throughout the body, primarily binding to mu opioid receptors for analgesic effects, and also influencing reward-centric and homeostasis-restoring behaviors. Their roles in psychiatric and neurodegenerative disorders make them a target of interest in research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Dermatology

Inhibition of IL-13: A New Pathway for Atopic Dermatitis

Kayadri Ratnarajah et al.

Summary: Dupilumab, the first biologic therapy approved in Canada for moderate-to-severe atopic dermatitis, is not universally effective and may cause adverse effects such as conjunctivitis in some patients. IL-13 inhibitors lebrikizumab and tralokinumab have shown promising efficacy and safety in clinical trials for AD, providing a potential alternative treatment option for patients with moderate-to-severe AD.

JOURNAL OF CUTANEOUS MEDICINE AND SURGERY (2021)

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Review Dermatology

Gut-Brain-Skin Axis in Psoriasis: A Review

Guang Chen et al.

Summary: Psoriasis is a common skin disease characterized by chronic inflammation and complex etiology. Research suggests that the gut microbiota may act as a bridge between the immune and nervous systems, impacting the regulation of neurotransmitters. Studies indicate that manipulating neurotransmitter levels by bacteria could potentially influence host physiology.

DERMATOLOGY AND THERAPY (2021)

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Article Dermatology

Nemolizumab is associated with a rapid improvement in atopic dermatitis signs and symptoms: subpopulation (EASI ≥ 16) analysis of randomized phase 2B study

J. I. Silverberg et al.

Summary: Nemolizumab resulted in rapid and sustained improvements in inflammation, pruritus, and sleep in patients with moderate-to-severe AD with an EASI score >= 16.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Article Cell Biology

Morphine acts on spinal dynorphin neurons to cause itch through disinhibition

Eileen Nguyen et al.

Summary: The study found that morphine-induced itch is caused by neurons rather than mast cells, and spinal dynorphin neurons play an important role in mice. Agonism of the kappa-opioid receptor can alleviate morphine-induced itch, challenging the long-standing use of antihistamines.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

Jussi Kupari et al.

Summary: This study classified non-human primate dorsal root ganglion sensory neurons based on their transcriptome and mapped human pain heritability to neuronal types. The findings revealed the cellular origin of chronic pain by showing genome-wide associations converging on two different neuronal types with different genetic susceptibilities for chronic pain.

NATURE COMMUNICATIONS (2021)

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Article Dermatology

The Role of Photoprotection in Optimizing the Treatment of Atopic Dermatitis

Jaime Piquero-Casals et al.

Summary: Atopic dermatitis is a chronic inflammatory skin disease with notable phenotypic variability influenced by genetics, immune function, and the environment. Impairment of the skin barrier plays a significant role in the pathogenesis of AD. The exposome, sum of external factors, including sun exposure, affects AD flares and prevalence variation.

DERMATOLOGY AND THERAPY (2021)

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Review Biochemistry & Molecular Biology

Intractable Itch in Atopic Dermatitis: Causes and Treatments

Yoshie Umehara et al.

Summary: Itch or pruritus is a hallmark of atopic dermatitis and is believed to be a signal of danger from various environmental factors or physiological abnormalities. While histamine is a well-known substance inducing itch, H-1-antihistamines may not be fully effective against intractable itch in patients with atopic dermatitis. Treatment of the underlying conditions that cause itch is necessary to improve the quality of life of patients with atopic dermatitis.

BIOMEDICINES (2021)

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Article Biology

Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

Minh Q. Nguyen et al.

Summary: Through single nuclear transcriptomics of human DRG neurons, it was found that different types of neurons share similarities in their transcriptomic features, but there are species differences in the expression of genes related to sensory function. Surprisingly, several transcriptomic classes without clear equivalents in other species were identified.

ELIFE (2021)

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Review Medicine, Research & Experimental

Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression

Xiaoxu Wang et al.

Summary: Psoriasis and depression are believed to be interrelated, and the gut-brain-skin axis may play a crucial role in the overlapping mechanisms between the two conditions.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Biochemistry & Molecular Biology

Endogenous Opioid Peptides and Alternatively Spliced Mu Opioid Receptor Seven Transmembrane Carboxyl-Terminal Variants

Anna Abrimian et al.

Summary: Endogenous opioid peptides, including enkephalins, dynorphins, and beta-endorphin, act through MOR, DOR, and KOR receptors, playing important roles in analgesia and various biological processes. The OPRM1 gene undergoes extensive pre-mRNA splicing, generating multiple splice variants, with the 7TM C-terminal variants playing a key role in the pharmacological functions of endogenous opioid peptides.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Comparative Analysis of the Microbiome across the Gut-Skin Axis in Atopic Dermatitis

Dong Hoon Park et al.

Summary: Atopic dermatitis is a refractory and relapsing skin disease with a complex etiology involving congenital malformations and environmental factors. Recent advances in research on gut-skin connections have provided new insights for the treatment of AD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Pharmacology & Pharmacy

Influence of G protein-biased agonists of μ-opioid receptor on addiction-related behaviors

Lucja Kudla et al.

Summary: The development of G protein-biased opioid agonists shows promise in reducing opioid side effects, but data regarding their addictive properties are inconsistent. More research is needed to determine the potential of these compounds in addressing opioid addiction.

PHARMACOLOGICAL REPORTS (2021)

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Review Biochemistry & Molecular Biology

Biased ligands at opioid receptors: Current status and future directions

Tao Che et al.

Summary: The opioid crisis has led to a search for safer and more effective opioids. The discovery of biased opioid ligands offers a potential alternative, but questions remain about their therapeutic benefits. More research is needed in this important area to understand the implications of biased agonism.

SCIENCE SIGNALING (2021)

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Review Anesthesiology

Evaluation of Therapies for Peripheral and Neuraxial Opioid-induced Pruritus based on Molecular and Cellular Discoveries

Eileen Nguyen et al.

Summary: Opioids are commonly used for pain management worldwide, but their side effect of pruritus limits their clinical use. This review discusses the mechanisms and clinical management of opioid-induced pruritus, highlighting recent discoveries and emerging therapies such as selective kappa-opioid receptor agonists.

ANESTHESIOLOGY (2021)

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Review Oncology

Novel Targeted Biological Agents for the Treatment of Atopic Dermatitis

Nan Yang et al.

Summary: Atopic dermatitis is a common inflammatory skin disease characterized by intense itch, eczematous lesions, and a chronic course. Treatment options include topical therapies, phototherapy, and systemic immunosuppressants, but relapse and side effects may occur. Biological agents targeting cytokines have shown promise in treating atopic dermatitis.

BIODRUGS (2021)

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Article Immunology

Methionine enkephalin activates autophagy and stimulates tumour cell immunogenicity in human cutaneous squamous cell carcinoma

Xueli Bai et al.

Summary: The study found that endogenous methionine enkephalin can effectively inhibit the growth of cutaneous squamous cell carcinoma by regulating cell autophagy and activating dendritic cells.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Immunological Aspects of Skin Aging in Atopic Dermatitis

Georgeta St Bocheva et al.

Summary: The aging skin undergoes immunosenescence and immunological alterations, which together with environmental stressors and genetic factors can lead to immune dysregulation and epidermal barrier abnormalities, facilitating the late onset of atopic dermatitis (AD) in the elderly. While healthy aged skin shows overproduction of cytokines, older AD patients have decreased levels of Th2/Th22 related cytokines and increased expression of terminal differentiation markers, reflecting the persistence of AD in an aged skin environment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis

Lai-San Wong et al.

Summary: Atopic dermatitis is a prototypic inflammatory disease characterized by intense itching, with multifactorial pathophysiology involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. Recent research has shown that pruritogens not only trigger itch but also interact with immune cells and act as inflammatory mediators, worsening the severity of atopic dermatitis. Targeted therapies for atopic dermatitis focus on the interaction between pruritogens and inflammatory molecules.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Antipruritic Effect of Nalbuphine, a Kappa Opioid Receptor Agonist, in Mice: A Pan Antipruritic

Saadet Inan et al.

Summary: The study demonstrated that nalbuphine inhibits scratching induced by multiple pruritogens and produces its effects through KORs.

MOLECULES (2021)

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Review Dermatology

TH2 sensitization in the skin-gut-brain axis: How early-life Th2-mediated inflammation may negatively perpetuate developmental and psychologic abnormalities

LaDonya Jackson-Cowan et al.

Summary: The study explores the potential associations between atopic dermatitis, asthma, allergic rhinitis, and food allergies with developmental delays in children, suggesting that unregulated increases in Th2-driven inflammation may have detrimental effects on the developing brain. It also discusses the possible linkage between Th2 sensitization and cognitive dysfunction, as well as developmental and psychologic abnormalities in children.

PEDIATRIC DERMATOLOGY (2021)

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Review Cell Biology

Current Insights into Immunology and Novel Therapeutics of Atopic Dermatitis

Hidaya A. Kader et al.

Summary: Atopic dermatitis (AD) is a prevalent inflammatory disease affecting up to one fifth of the population in developed countries, characterized by itching and eczema. It can lead to secondary allergies such as allergic rhinitis and asthma. The complex pathophysiology involves genetic predisposition, disrupted epidermal barrier, and immune dysregulation, with current management strategies limited to symptomatic treatment.

CELLS (2021)

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Overcome the barriers of the skin: exosome therapy

Gi Hoon Yang et al.

Summary: Exosomes are nano-sized vesicles carrying diverse biomolecules, serving as potential biomarkers in skin therapy. They play a crucial role in communication and regeneration of skin cells, but face challenges in engineering and commercialization. Further research is needed to overcome limitations and explore future perspectives in exosome technology for skin treatments.

BIOMATERIALS RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors

Jolien De Neve et al.

Summary: One of the main challenges in contemporary medicinal chemistry is the development of safer analgesics that can circumvent the severe side effects of the gold standard opioids. The discovery of biased agonism has exponentially increased the importance of this field in pharmacology over the past decade. New therapeutic molecules inducing biased response at opioid receptors show great promise in avoiding specific side effects.

RSC MEDICINAL CHEMISTRY (2021)

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Review Dermatology

Basics and recent advances in the pathophysiology of atopic dermatitis

Takeshi Nakahara et al.

Summary: Atopic dermatitis is a chronic inflammatory skin disease characterized by skin barrier dysfunction, inflammation, and intense itch. The pathophysiology involves abnormalities in filaggrin, intercellular lipids, and tight junctions leading to skin inflammation and itch.

JOURNAL OF DERMATOLOGY (2021)

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Article Clinical Neurology

Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition

Zilong Wang et al.

Summary: The study revealed that intrathecal morphine induces itch by acting on MOR on spinal inhibitory interneurons, leading to disinhibition of spinal itch circuit. The data provide mechanistic insights into the treatment of chronic itch with opioid receptor antagonists like naloxone.

BRAIN (2021)

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Article Clinical Neurology

Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish

Juanjuan Luo et al.

Summary: The molecular pathogenesis of glioblastoma is critical for human gliomagenesis, with RTK/Ras/PI3K, RB, and TP53 pathways playing key roles. Using transgenic zebrafish with single or multiple gene deletions, researchers induced gliomagenesis and found that nf1 mutation alone had low efficiency, but combined deletions of nf1;tp53 and rb1;tp53 resulted in higher tumor incidences with advanced histology. Bioinformatics analysis revealed alterations in critical pathways like RTK/Ras/PI3K, cell cycle, and focal adhesion, highlighting their importance in gliomagenesis initiation and development. Tumors in zebrafish models showed significant similarities to human gliomas, and temozolomide treatment effectively suppressed gliomagenesis, mimicking responses seen in clinical glioma treatment. This study provides a potential tool for genetically studying gliomagenesis and screening targeted anti-tumor compounds for glioma treatment.

BRAIN (2021)

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Interleukin-13: Targeting an underestimated cytokine in atopic dermatitis

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Review Dermatology

Neuroimmune interactions in chronic itch of atopic dermatitis

G. Yosipovitch et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

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Review Dermatology

Bacterial extracellular vesicles: A new way to decipher host-microbiota communications in inflammatory dermatoses

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EXPERIMENTAL DERMATOLOGY (2020)

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Functional expression and pharmacological modulation of TRPM3 in human sensory neurons

Laura Vangeel et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Intra-epidermal nerve endings progress within keratinocyte cytoplasmic tunnels in normal human skin

Matthieu Talagas et al.

EXPERIMENTAL DERMATOLOGY (2020)

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

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Opioid receptors expression in the skin of haemodialysis patients suffering from uraemic pruritus

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JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

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ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2020)

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Alpha-neoendorphin can reduce UVB-induced skin photoaging by activating cellular autophagy

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Michael Soeberdt et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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EXPERIMENTAL DERMATOLOGY (2020)

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Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

Masutaka Furue

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Pathogenic implication of epidermal scratch injury in psoriasis and atopic dermatitis

Kazuhisa Furue et al.

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Non-neuronal kappa-opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skinex vivo

Jeremy Cheret et al.

JOURNAL OF DERMATOLOGY (2020)

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Regulation of pro-opiomelanocortin (POMC) gene transcription by interleukin-31 via early growth response 1 (EGR-1) in HaCaT keratinocytes

Hyunjin Yeo et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Review Pharmacology & Pharmacy

Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions

Lloyd D. Fricker et al.

MOLECULAR PHARMACOLOGY (2020)

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The Role of Environmental Exposures in Atopic Dermatitis

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Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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NATURE COMMUNICATIONS (2020)

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Genetic and Epigenetic Aspects of Atopic Dermatitis

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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beta-Neoendorphin Enhances Wound Healing by Promoting Cell Migration in Keratinocyte

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MOLECULES (2020)

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Crosstalk between Opioid and Anti-Opioid Systems: An Overview and Its Possible Therapeutic Significance

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Adipokines in the Skin and in Dermatological Diseases

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Yozo Ishiuji

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Review Dermatology

Characteristics and roles of extracellular vesicles released by epidermal keratinocytes

U. T. T. Than et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

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Review Neurosciences

Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation

Hanna Siiskonen et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Review Microbiology

Staphylococcus aureus and the Cutaneous Microbiota Biofilms in the Pathogenesis of Atopic Dermatitis

Enea Gino Di Domenico et al.

MICROORGANISMS (2019)

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Article Allergy

The microbiome in patients with atopic dermatitis

Amy S. Paller et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Review Allergy

Atopic dermatitis endotypes and implications for targeted therapeutics

Tali Czarnowicki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Pharmacology & Pharmacy

Nalbuphine, a kappa opioid receptor agonist and mu opioid receptor antagonist attenuates pruritus, decreases IL-31, and increases IL-10 in mice with contact dermatitis

Saadet Inan et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

Blue light (λ=453 nm) nitric oxide dependently induces β-endorphin production of human skin keratinocytes in-vitro and increases systemic β-endorphin levels in humans in-vivo

Isabel Albers et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Neurosciences

Dorsal Horn Gastrin-Releasing Peptide Expressing Neurons Transmit Spinal Itch But Not Pain Signals

Gioele W. Albisetti et al.

JOURNAL OF NEUROSCIENCE (2019)

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Article Dermatology

The uses of naltrexone in dermatologic conditions

Brigette Lee et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

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Review Dermatology

Antimicrobial peptides activity in the skin

Anna Herman et al.

SKIN RESEARCH AND TECHNOLOGY (2019)

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Review Dermatology

Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions A Systematic Review

Chloe Ekelem et al.

JAMA DERMATOLOGY (2019)

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Review Immunology

The Role of Opioid Receptors in Immune System Function

Toby K. Eisenstein

FRONTIERS IN IMMUNOLOGY (2019)

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Review Allergy

Endocrine systems of the skin

Kamil Leis et al.

POSTEPY DERMATOLOGII I ALERGOLOGII (2019)

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Article Dermatology

45th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) Zurich, Switzerland, March 7-10, 2018

EXPERIMENTAL DERMATOLOGY (2018)

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Review Pharmacology & Pharmacy

Insights into future therapeutics for atopic dermatitis

Taylor Edwards et al.

EXPERT OPINION ON PHARMACOTHERAPY (2018)

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Review Immunology

Taking the lead - how keratinocytes orchestrate skin T cell immunity

M. M. Klicznik et al.

IMMUNOLOGY LETTERS (2018)

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Article Allergy

New mechanism underlying IL-31-induced atopic dermatitis

Jianghui Meng et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Dermatology

New therapies for atopic dermatitis: Additional treatment classes

Paras P. Vakharia et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

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Article Neurosciences

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

Martin Haring et al.

NATURE NEUROSCIENCE (2018)

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Review Neurosciences

Peripheral and Central Mechanisms of Itch

Xintong Dong et al.

NEURON (2018)

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Review Immunology

Skin neurogenic inflammation

Jae Eun Choi et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

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Article Cell Biology

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

Anupama Sathyamurthy et al.

CELL REPORTS (2018)

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Article Clinical Neurology

Nociceptin/orphanin FQ opioid peptide-receptor expression in pachyonychia congenita

Baohan Pan et al.

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2018)

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Article Neurosciences

Kappa Opioid Receptor Distribution and Function in Primary Afferents

Lindsey M. Snyder et al.

NEURON (2018)

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Article Multidisciplinary Sciences

Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation

Helvira Melo et al.

SCIENTIFIC REPORTS (2018)

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Article Dermatology

Abstracts

EXPERIMENTAL DERMATOLOGY (2018)

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Review Allergy

Itch: From mechanism to (novel) therapeutic approaches

Gil Yosipovitch et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Review Dermatology

Recent advances in the endocrinology of the sebaceous gland

Attila G. Szollosi et al.

DERMATO-ENDOCRINOLOGY (2018)

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Review Physiology

Tight junctions in skin inflammation

Katja Baesler et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2017)

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Review Dermatology

Keratinocytes as sensors and central players in the immune defense against Staphylococcus aureus in the skin

Katharina Bitschar et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2017)

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Article Dermatology

Nrf2 Promotes Keratinocyte Proliferation in Psoriasis through Up-Regulation of Keratin 6, Keratin 16, and Keratin 17

Luting Yang et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

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Article Chemistry, Medicinal

Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo

Michael Soeberdt et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Article Biochemistry & Molecular Biology

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Katherine Lansu et al.

NATURE CHEMICAL BIOLOGY (2017)

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Article Neurosciences

Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord

Shuohao Sun et al.

NEURON (2017)

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Article Anesthesiology

A central role for R7bp in the regulation of itch sensation

Mritunjay Pandey et al.

PAIN (2017)

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Article Medical Laboratory Technology

Opioids and opioid receptors orchestrate wound repair

Ping Wang et al.

TRANSLATIONAL RESEARCH (2017)

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Article Biology

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

Talisia Quallo et al.

eLife (2017)

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Article Biology

Anti-nociceptive action of peripheral muopioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

Sandeep Dembla et al.

ELIFE (2017)

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Review Allergy

Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies

Masutaka Furue et al.

ALLERGOLOGY INTERNATIONAL (2017)

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Article Multidisciplinary Sciences

Investigating endogenous μ-opioid receptors in human keratinocytes as pharmacological targets using novel fluorescent ligand

Cheryl Leong et al.

PLOS ONE (2017)

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Article Dermatology

Involvement of mu-opioid Receptors and kappa-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice

Nobuaki Takahashi et al.

ACTA DERMATO-VENEREOLOGICA (2017)

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Article Dermatology

Opioid Receptors in Psoriatic Skin: Relationship with Itch

Piotr Kupczyk et al.

ACTA DERMATO-VENEREOLOGICA (2017)

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Article Dermatology

Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis

Ami Totsuka et al.

EUROPEAN JOURNAL OF DERMATOLOGY (2017)

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Review Dermatology

Psoriasis and Atopic Dermatitis

Christopher E. M. Griffiths et al.

DERMATOLOGY AND THERAPY (2017)

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Article Dermatology

Possible role of proenkephalin in psoriasis

N. A. Nagui et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2016)

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Article Neurosciences

Signaling Mechanism of Cannabinoid Receptor-2 Activation-Induced β-Endorphin Release

Fang Gao et al.

MOLECULAR NEUROBIOLOGY (2016)

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Article Pharmacology & Pharmacy

Neurotensin-based hybrid peptide's anti-inflammatory activity in murine model of a contact sensitivity response

Katarzyna Kaczynska et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

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Article Dermatology

Opioids and skin homeostasis, regeneration and ageing - What's the evidence?

Paul L. Bigliardi et al.

EXPERIMENTAL DERMATOLOGY (2016)

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Letter Dermatology

Topical nalfurafine exhibits anti-inflammatory and anti-pruritic effects in a murine model of AD

Graham Elliott et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2016)

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Editorial Material Anesthesiology

Insight into B5-I spinal interneurons and their role in the inhibition of itch and pain

Michael C. Chiang et al.

PAIN (2016)

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Article Biochemistry & Molecular Biology

Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease

Dong Joo Yang et al.

PEPTIDES (2016)

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Review Medicine, Research & Experimental

Molecular mechanisms of pruritus

J. Meng et al.

CURRENT RESEARCH IN TRANSLATIONAL MEDICINE (2016)

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Article Dermatology

Nalfurafine Suppresses Pruritogen- and Touch-evoked Scratching Behavior in Models of Acute and Chronic Itch in Mice

Tasuku Akiyama et al.

ACTA DERMATO-VENEREOLOGICA (2015)

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Article Immunology

Characteristics of scratching behavior in ADJM mice (atopic dermatitis from Japanese mice)

Tasuku Nakasone et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2015)

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Article Medicine, Research & Experimental

Mutations in the opioid growth factor receptor in human cancers alter receptor function

Nancy P. Kren et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)

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Editorial Material Dermatology

On the Role of the Endogenous Opioid System in Regulating Epidermal Homeostasis

Andrzej T. Slominski

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

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Article Dermatology

The δ-Opioid Receptor Affects Epidermal Homeostasis via ERK-Dependent Inhibition of Transcription Factor POU2F3

Christine Neumann et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

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Review Dermatology

Role of sebaceous glands in inflammatory dermatoses

Vivian Y. Shi et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

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Article Multidisciplinary Sciences

Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates

Heeseung Lee et al.

SCIENTIFIC REPORTS (2015)

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Article Pharmacology & Pharmacy

Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration

P. L. Bigliardi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

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Article Neurosciences

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

Dmitry Usoskin et al.

NATURE NEUROSCIENCE (2015)

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Article Pediatrics

Interleukin-31 promotes helper T cell type-2 inflammation in children with allergic rhinitis

Wenlong Liu et al.

PEDIATRIC RESEARCH (2015)

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Review Dermatology

Nalfurafine hydrochloride to treat pruritus: a review

Shigeki Inui

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2015)

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Review Allergy

Novel insights into the role of immune cells in skin and inducible skin-associated lymphoid tissue (iSALT)

Sachiko Ono et al.

ALLERGO JOURNAL (2015)

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Article Biochemistry & Molecular Biology

Skin β-Endorphin Mediates Addiction to UV Light

Gillian L. Fell et al.

CELL (2014)

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Article Dermatology

ADF Abstracts 2014

EXPERIMENTAL DERMATOLOGY (2014)

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Article Dermatology

Effects of electroacupuncture on capsaicin-induced model of atopic dermatitis in rats

Dal-Lim Jung et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2014)

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Review Gastroenterology & Hepatology

Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives

Marta Sobczak et al.

JOURNAL OF GASTROENTEROLOGY (2014)

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Review Neurosciences

Sensory neurons and circuits mediating itch

Robert H. LaMotte et al.

NATURE REVIEWS NEUROSCIENCE (2014)

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Article Neurosciences

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

Adam P. Kardon et al.

NEURON (2014)

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Article Neurosciences

The kinin B1 receptor mediates alloknesis in a murine model of inflammation

Jumian Feng et al.

NEUROSCIENCE LETTERS (2014)

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Article Biochemistry & Molecular Biology

beta-casomorphin-7 alters mu-opioid receptor and dipeptidyl peptidase IV genes expression in children with atopic dermatitis

Ewa Fiedorowicz et al.

PEPTIDES (2014)

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Review Anesthesiology

Opioids and immune modulation: more questions than answers

M. Al-Hashimi et al.

BRITISH JOURNAL OF ANAESTHESIA (2013)

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Article Biochemistry & Molecular Biology

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

Sarah R. Wilson et al.

CELL (2013)

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Review Endocrinology & Metabolism

Key Role of CRF in the Skin Stress Response System

Andrzej T. Slominski et al.

ENDOCRINE REVIEWS (2013)

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Article Anesthesiology

Involvement of peripheral cannabinoid and opioid receptors in -caryophyllene-induced antinociception

S. Katsuyama et al.

EUROPEAN JOURNAL OF PAIN (2013)

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Review Allergy

The cutaneous innate immune response in patients with atopic dermatitis

I-Hsin Kuo et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Article Nutrition & Dietetics

Mild exercise suppresses exacerbation of dermatitis by increasing cleavage of the β-endorphin from proopiomelanocortin in NC/Nga mice

Keiichi Hiramoto et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2013)

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Article Dermatology

Phospholipase activity after β-endorphin exposure discriminates Malassezia strains isolated from healthy and seborrhoeic dermatitis skin

Ch. Vlachos et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2013)

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Article Pharmacology & Pharmacy

Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20

Patrycja Kleczkowska et al.

PHARMACOLOGICAL REPORTS (2013)

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Review Dermatology

Systemic Kappa Opioid Receptor Agonists in the Treatment of Chronic Pruritus: A Literature Review

Ngoc Quan Phan et al.

ACTA DERMATO-VENEREOLOGICA (2012)

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Article Urology & Nephrology

Efficacy and Safety of a Novel K-Agonist for Managing Intractable Pruritus in Dialysis Patients

Hiroo Kumagai et al.

AMERICAN JOURNAL OF NEPHROLOGY (2012)

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Article Dermatology

Mechanistic correlations between two itch biomarkers, cytokine interleukin-31 and neuropeptide β-endorphin, via STAT3/calcium axis in atopic dermatitis

C-H Lee et al.

BRITISH JOURNAL OF DERMATOLOGY (2012)

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Review Pharmacology & Pharmacy

Non-Analgesic Effects of Opioids: Peripheral Opioid Receptors as Promising Targets for Future Anti-Pruritic Therapies

Adam Reich et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

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Review Pharmacology & Pharmacy

Non-Analgesic Effects of Opioids: Opioid-induced Respiratory Depression

Merel Boom et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

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Letter Allergy

Increased serum CRH levels with decreased skin CRHR-1 gene expression in psoriasis and atopic dermatitis

Magdalini Vasiadi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Allergy

Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation

S. -W. Hong et al.

ALLERGY (2011)

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Article Biochemistry & Molecular Biology

Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids

Xian-Yu Liu et al.

CELL (2011)

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Article Dermatology

Regulated Proenkephalin Expression in Human Skin and Cultured Skin Cells

Andrzej T. Slominski et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

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Article Neurosciences

Influence of Endogenous Opioid Systems on T Lymphocytes as Assessed by the Knockout of Mu, Delta and Kappa Opioid Receptors

Ali G. Karaji et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2011)

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Article Neurosciences

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

Joris Vriens et al.

NEURON (2011)

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Article Immunology

Characterization of the skin fungal microbiota in patients with atopic dermatitis and in healthy subjects

Enshi Zhang et al.

MICROBIOLOGY AND IMMUNOLOGY (2011)

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Review Physiology

Sebocytes' makeup - Novel mechanisms and concepts in the physiology of the human sebaceous glands

Balazs I. Toth et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2011)

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Review Allergy

Pathogenesis and Treatment of Pruritus

Malcolm W. Greaves

CURRENT ALLERGY AND ASTHMA REPORTS (2010)

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Article Dermatology

Strong exercise stress exacerbates dermatitis in atopic model mice, NC/Nga mice, while proper exercise reduces it

Kumi Orita et al.

EXPERIMENTAL DERMATOLOGY (2010)

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Article Dermatology

μ-Opioid Receptor Is Induced by IL-13 within Lymph Nodes from Patients with Sezary Syndrome

Alan Benard et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

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Review Dermatology

Antipruritic treatment with systemic mu-opioid receptor antagonists: A review

Ngoc Quan Phan et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2010)

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Article Neurosciences

Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice

Sarah E. Ross et al.

NEURON (2010)

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Article Dermatology

Analysis of the prodynorphin promoter polymorphism in atopic dermatitis and disease-related pruritus

E. K. Greisenegger et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2009)

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Editorial Material Dermatology

Opioids and the skin - where do we stand?

Paul L. Bigliardi et al.

EXPERIMENTAL DERMATOLOGY (2009)

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Review Dermatology

Atopic Dermatitis: A Disease Caused by Innate Immune Defects?

Anna De Benedetto et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

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Article Cell Biology

The OGF-OGFr Axis Utilizes the p16(INK4a) and p21(WAF1/CIP1) Pathways to Restrict Normal Cell Proliferation

Fan Cheng et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

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Article Neurosciences

Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons

Steve Davidson et al.

NATURE NEUROSCIENCE (2009)

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Article Endocrinology & Metabolism

Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, α-MSH, and β-endorphin

Vivian Hook et al.

ENDOCRINE (2009)

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Review Dermatology

Epidermal surface lipids

Apostolos Pappas

DERMATO-ENDOCRINOLOGY (2009)

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Article Dermatology

Coexistence and upregulation of three types of opioid receptors, mu, delta and kappa, in human hypertrophic scars

B. Cheng et al.

BRITISH JOURNAL OF DERMATOLOGY (2008)

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Review Dermatology

The skin as a mirror of the soul: exploring the possible roles of serotonin

Klas Nordlind et al.

EXPERIMENTAL DERMATOLOGY (2008)

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Article Dermatology

The skin: an indispensable barrier

Ehrhardt Proksch et al.

EXPERIMENTAL DERMATOLOGY (2008)

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Review Medicine, General & Internal

Mechanisms of disease: Atopic dermatitis

Thomas Bieber

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Article Multidisciplinary Sciences

Beta-caryophyllene is a dietary cannabinoid

Juerg Gertsch et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Critical Care Medicine

Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage

Michael Frink et al.

SHOCK (2007)

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Article Neurosciences

Morphine reduces local cytokine expression and neutrophil infiltration after incision

J. David Clark et al.

MOLECULAR PAIN (2007)

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Article Dermatology

Possible roles of epidermal opioid systems in pruritus of atopic dermatitis

Mitsutoshi Tominaga et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Article Multidisciplinary Sciences

A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord

Yan-Gang Sun et al.

NATURE (2007)

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Article Dermatology

Treatment of pruritus with topically applied opiate receptor antagonist

Paul L. Bigliardi et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2007)

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Article Dermatology

Deletion of μ- and κ-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior

Mei Bigliardi-Qi et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Review Allergy

Role of vasculature in atopic dermatitis

Martin Steinhoff et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)

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Review Neurosciences

The neurobiology of itch

Akihiko Ikoma et al.

NATURE REVIEWS NEUROSCIENCE (2006)

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Article Dermatology

Transepidermal water loss, serum IgE and β-endorphin as important and independent biological markers for development of itch intensity in atopic dermatitis

C-H. Lee et al.

BRITISH JOURNAL OF DERMATOLOGY (2006)

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Article Cell Biology

Deletion of δ-opioid receptor in mice alters skin differentiation and delays wound healing

M Bigliardi-Qi et al.

DIFFERENTIATION (2006)

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Article Biochemistry & Molecular Biology

Detection of kappa and delta opioid receptors in skin -: Outside the nervous system

S Salemi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Article Immunology

Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway

S Roy et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Multidisciplinary Sciences

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

MM Ibrahim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Biochemistry & Molecular Biology

R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family

KA Martemyanov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Article Dermatology

Changes of epidermal mu-opiate receptor expression and nerve endings in chronic atopic dermatitis

M Bigliardi-Qi et al.

DERMATOLOGY (2005)

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Article Pharmacology & Pharmacy

Comparison of pharmacological activities of three distinct kappa ligands (salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo

Y Wang et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

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Article Endocrinology & Metabolism

Subcellular pathways of β-endorphin synthesis, processing, and release from immunocytes in inflammatory pain

SA Mousa et al.

ENDOCRINOLOGY (2004)

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Article Anesthesiology

Opioid-induced mast cell activation and vascular responses is not mediated by μ-opioid receptors:: An in vivo microdialysis study in human skin

JA Blunk et al.

ANESTHESIA AND ANALGESIA (2004)

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Article Dermatology

Mu-opiate receptor and beta-endorphin expression in nerve endings and keratinocytes in human skin

M Bigliardi-Qi et al.

DERMATOLOGY (2004)

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Article Biochemistry & Molecular Biology

Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury

A Khodorova et al.

NATURE MEDICINE (2003)

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Review Dermatology

Neurophysiology of pruritus - Cutaneous elicitation of itch

S Stander et al.

ARCHIVES OF DERMATOLOGY (2003)

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Article Dermatology

Different expression of mu-opiate receptor in chronic and acute wounds and the effect of beta-endorphin on transforming growth factor beta type II receptor and cytokeratin 16 expression

PL Bigliardi et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)

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Article Endocrinology & Metabolism

Localization of μ-opioid receptor 1A on sensory nerve fibers in human skin

S Ständer et al.

REGULATORY PEPTIDES (2002)

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Article Dermatology

Efficacy of naltrexone on acetylcholine-induced alloknesis in atopic eczema

G Heyer et al.

EXPERIMENTAL DERMATOLOGY (2002)

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Review Neurosciences

The biology of the opioid growth factor receptor (OGFr)

IS Zagon et al.

BRAIN RESEARCH REVIEWS (2002)

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Article Biochemistry & Molecular Biology

Specific stimulation of migration of human keratinocytes by μ-opiate receptor agonists

PL Bigliardi et al.

JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH (2002)

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Article Dermatology

Presence of immunoreactive β-endorphin in human skin

M Wintzen et al.

EXPERIMENTAL DERMATOLOGY (2001)

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Article Surgery

Morphine directs T cells toward TH2 differentiation

S Roy et al.

SURGERY (2001)

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Article Pharmacology & Pharmacy

Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells

T Kimura et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2000)

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Article Cell Biology

The opioid growth factor, [Met5]-enkephalin, inhibits DNA synthesis during recornification of mouse tail skin

RP Wilson et al.

CELL PROLIFERATION (2000)

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Article Hematology

The opioid antagonist naloxone induces a shift from Type 2 to Type 1 cytokine pattern in BALB/cJ mice

P Sacerdote et al.

BLOOD (2000)

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Article Dermatology

β-endorphin stimulates cytokeratin 16 expression and downregulates μ-opiate receptor expression in human epidermis

M Bigliardi-Qi et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2000)

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Article Biochemistry & Molecular Biology

An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression

A Zimprich et al.

JOURNAL OF NEUROCHEMISTRY (2000)

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