Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment

Chronic inflammation is one of the hallmarks of chronic wounds and is tightly coupled to immune regulation. The dysregulation of the immune system leads to continuing inflammation and impaired wound healing and, subsequently, to chronic skin wounds. In this review, we discuss the role of the immune system, the involvement of inflammatory mediators and reactive oxygen species, the complication of bacterial infections in chronic wound healing, and the still-underexplored potential of natural bioactive compounds in wound treatment. We focus on natural compounds with antioxidant, anti-inflammatory, and antibacterial activities and their mechanisms of action, as well as on recent wound treatments and therapeutic advancements capitalizing on nanotechnology or new biomaterial platforms.

Automated summary

This review discusses the crucial role of chronic inflammation in chronic wounds and its close association with immune regulation. The dysregulation of the immune system leads to persistent inflammation and impaired wound healing, resulting in chronic skin wounds. Furthermore, it explores the potential of natural bioactive compounds in wound treatment, particularly focusing on compounds with antioxidant, anti-inflammatory, and antibacterial activities, as well as recent advancements in wound treatments utilizing nanotechnology or new biomaterial platforms.