期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms23094576
关键词
lysosome; endosome; acidification; coronaviruses; endocytosis; autophagy; SARS-CoV-2; virus cycle; immune evasion; immunity
资金
- Oswaldo Cruz Foundation/FIOCRUZ Inova Program
- Conselho Nacional De Desenvolvimento Cientifico E Tecnologico (CNPq)
This article describes and discusses the various functions of the endolysosomal system, including homeostasis and its role during viral infections. The authors highlight that pathogens have evolved strategies to avoid and manipulate lysosomal function in order to survive and reproduce.
This review aims to describe and discuss the different functions of the endolysosomal system, from homeostasis to its vital role during viral infections. We will initially describe endolysosomal system's main functions, presenting recent data on how its compartments are essential for host defense to explore later how SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) and other coronaviruses subvert these organelles for their benefit. It is clear that to succeed, pathogens' evolution favored the establishment of ways to avoid, escape, or manipulate lysosomal function. The unavoidable coexistence with such an unfriendly milieu imposed on viruses the establishment of a vast array of strategies to make the most out of the invaded cell's machinery to produce new viruses and maneuvers to escape the host's defense system.
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