☆ 4.7 Review

Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Dentistry, Oral Surgery & Medicine

Management of temporomandibular disorders with transcutaneous electrical nerve stimulation: A systematic review

Aurelie Fertout et al.

Summary: This systematic review aimed to assess the effectiveness of transcutaneous electrical nerve stimulation (TENS) for temporomandibular disorders (TMD) management and determine the indications and appropriate application modalities. Results showed that TENS provided significant pain relief and functional improvement for TMD patients. However, studies comparing TENS to other physical medicine modalities reported similar results. Further research is needed to optimize the use of TENS for different types of TMD.

CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE (2022)

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Article Dentistry, Oral Surgery & Medicine

Comparison of the efficiency of two alternative therapies for the management of temporomandibular disorders

Funda Esra Yamaner et al.

Summary: This study investigates the effect of ozone and low-level laser therapies on pain and function in patients with disc displacement with reduction. Results show that ozone treatment significantly reduces pain levels and improves pressure pain threshold scores and mandibular movements. Laser treatment also has positive effects on pressure pain threshold scores in the masseter inferior.

CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE (2022)

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Review Environmental Sciences

The expression of microRNAs and exposure to environmental contaminants related to human health: a review

Maria Rosaria Tumolo et al.

Summary: This review provides an overview of studies investigating the impact of air pollution, organic chemicals, and heavy metals on miRNA expression and the potential biologic effects on humans.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH (2022)

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Article Orthopedics

Efficacy of kinesio taping on hand functioning in patients with mild carpal tunnel syndrome. A double-blind randomized controlled trial

Alessandro de Sire et al.

Summary: This study aimed to investigate the effectiveness of Kinesio taping (KT) compared to a sham taping on symptoms and hand function in patients with mild Carpal Tunnel Syndrome (CTS). The results showed that after 5 weeks of treatment, there was a significant improvement in hand function and symptoms in the KT group, indicating that KT may be an effective treatment method.

JOURNAL OF HAND THERAPY (2022)

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Review Radiology, Nuclear Medicine & Medical Imaging

Image-guided spinal injection for pain management

Osanna Wong et al.

Summary: Radiculopathy and spinal pain are debilitating conditions affecting millions of people worldwide annually. Minimally invasive corticosteroid injections are the mainstay intervention for those not responding to conservative treatment, and imaging modalities have become standard for accurate needle placement and targeting of localized pathologies.

JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY (2022)

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Review Orthopedics

Efficacy of rehabilitation on reducing pain in muscle-related temporomandibular disorders: A systematic review and meta-analysis of randomized controlled trials

Martina Ferrillo et al.

Summary: This systematic review with meta-analysis aimed to evaluate the efficacy of rehabilitative approaches in reducing pain in patients with muscle-related temporomandibular disorders (TMD). The results suggested that rehabilitative interventions might be effective in reducing pain in muscle-related TMD patients.

JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION (2022)

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Review Endocrinology & Metabolism

Osteoarthritis: Current Molecular Biomarkers and the Way Forward

Virginia Byers Kraus et al.

Summary: Researchers and patients hope for the development of treatments that modify the disease process of osteoarthritis, but the use of biomarkers in drug development faces challenges in terms of validation and cost-effectiveness.

CALCIFIED TISSUE INTERNATIONAL (2021)

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Review Rehabilitation

Comparative Effectiveness of Orthoses for Thumb Osteoarthritis: A Systematic Review and Network Meta-analysis

Nicola Marotta et al.

Summary: This study evaluated the effectiveness of various orthoses for carpometacarpal osteoarthritis of the thumb through a network meta-analysis. The results showed that all splints were superior to placebo in reducing pain intensity, with the rigid CMC-MCP splint ranked as the top intervention for pain relief and the short thermoplastic CMC splint as the best treatment for function improvement.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2021)

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Review Rehabilitation

Rehabilitative Good Practices in the Treatment of Sarcopenia A Narrative Review

Francesco Agostini et al.

Summary: Rehabilitative management of patients with sarcopenia should be personalized and include exercise and nutritional supplementation. Most literature agrees that exercise and diet supplementation are cornerstones of rehabilitation treatment for patients with sarcopenia. Adequate lifestyle received high-grade recommendations in the guidelines analyzed.

AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION (2021)

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Article Medicine, Research & Experimental

Influence of pain-related psychological factors on therapeutic outcomes in patients with chronic low back pain after oxygen-ozone treatment: a case-series

Francesca Cantele et al.

Summary: The study identified significant improvement in pain and functional status after intramuscular oxygen-ozone therapy in patients with chronic low back pain. Anxiety, mood, and psychological well-being were found to be important predictors of therapeutic outcome, with patients experiencing psychological distress showing better results post-treatment.

EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (2021)

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Article Pharmacology & Pharmacy

Ozone Therapy Alleviates Monosodium Urate Induced Acute Gouty Ar-thritis in Rats Through Inhibition of NLRP3 Inflammasome

Doaa M. Abdullah et al.

Summary: The study demonstrated that ozone therapy was effective in reducing edema, pro-inflammatory cytokines, lipid peroxidation, NLRP3, procaspase-1, caspase-1, interleukin1 beta levels in synovial tissue, while enhancing antioxidant defense system. Ozone therapy also improved histological features in gouty arthritic rats, suggesting its potential as a treatment for gouty arthritis.

CURRENT DRUG THERAPY (2021)

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Article Oncology

Intrathecal injection of ozone alleviates CCI-induced neuropathic pain via the GluR6-NF-κB/p65 signalling pathway in rats

Weiguang Zhang et al.

Summary: The study revealed that ozone may alleviate neuropathic pain in rats with chronic constriction injury of the sciatic nerve by modulating the spinal GluR6-NF-kappa B/p65 signaling pathway. Additionally, ozone was found to inhibit pain behaviors and suppress the expression of spinal inflammatory mediators, indicating its potential as a therapeutic intervention for neuropathic pain.

MOLECULAR MEDICINE REPORTS (2021)

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Article Oncology

Jaw exercise therapy for the treatment of trismus in head and neck Cancer: a prospective three-year follow-up study

Ove Karlsson et al.

Summary: The study found that jaw exercise therapy can significantly increase maximal interincisal opening, reduce symptoms related to trismus, and improve health-related quality-of-life. It is recommended to initiate structured jaw exercise therapy early and continue for the long term.

SUPPORTIVE CARE IN CANCER (2021)

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Review Medicine, General & Internal

Neuropathic Pain and Rehabilitation: A Systematic Review of International Guidelines

Andrea Bernetti et al.

Summary: Neuropathic pain requires a multidisciplinary approach comprising pharmacologic and nonpharmacologic interventions, with rehabilitation playing a key role in non-pharmacological treatment. Further research is needed to better define a rehabilitative treatment strategy.

DIAGNOSTICS (2021)

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Article Orthopedics

The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial

Seyed Ahmad Raeissadat et al.

Summary: Ozone injection showed rapid effects and better short-term results after 2 months, but its therapeutic effects did not persist after 6 months. PRP and PRGF were superior to ozone in long-term management, with the effects lasting for 12 months.

BMC MUSCULOSKELETAL DISORDERS (2021)

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Article Endocrinology & Metabolism

Inflammation: between obesity, diabetes and exercise

Matthias Bluher

Summary: Obesity poses a major health challenge, increasing the risk of various diseases, but regular exercise can improve insulin sensitivity and reduce visceral fat mass.

DIABETOLOGE (2021)

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Article Orthopedics

Ultrasound-guided periradicular oxygen-ozone injections as a treatment option for low back pain associated with sciatica

Cristiano Sconza et al.

Summary: The study describes the clinical outcomes of ultrasound-guided periradicular injection of oxygen-ozone for low back pain associated with sciatica in patients with symptomatic L5-S1 disc herniation. It is a safe and effective minimally invasive treatment that can improve both low back pain and radiating pain.

INTERNATIONAL ORTHOPAEDICS (2021)

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Article Medicine, Research & Experimental

Integration of focal vibration and intra-articular oxygen-ozone therapy in rehabilitation of painful knee osteoarthritis

Teresa Paolucci et al.

Summary: The integrated rehabilitation protocol involving O2O3 injections and mFV for 3 weeks significantly reduces pain, increases autonomy in daily life activities, and strengthens the quadriceps femoris in patients with knee osteoarthritis.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Oxygen-Ozone Therapy in the Rehabilitation Field:State of the Art on Mechanisms of Action, Safety andEffectiveness in Patients with Musculoskeletal Disorders

Alessandro de Sire et al.

Summary: Oxygen-ozone therapy has gained significant interest in rehabilitation, with its chemical properties playing a crucial role in exerting positive effects on various pathological conditions. The therapy appears to reduce pain and improve functioning through moderate oxidative stress. Further research is needed to investigate its therapeutic effects on a wider range of musculoskeletal disorders.

BIOMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Long-term evaluation of temporomandibular disorders in association with cytokine and autoantibody status in young women

Chunghwan Son et al.

Summary: Research has shown that TMD patients with higher pain intensity and longer pain duration have higher levels of systemic inflammation, suggesting that immunological disturbance may be a potential factor in chronic TMD pain. These results indicate a need for further investigation into the role of immunological factors in the diagnosis and treatment of TMD.

CYTOKINE (2021)

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Article Orthopedics

Does paravertebral ozone injection have efficacy as an additional treatment for acute lumbar disc herniation? A randomized, double-blind, placebo-controlled study

Hamza Sucuoglu et al.

Summary: The study showed that paravertebral ozone injections can effectively reduce pain and disability in patients with acute lumbar disc herniation, with better outcomes compared to the placebo group.

JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION (2021)

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Article Dentistry, Oral Surgery & Medicine

Diagnostic criteria for temporomandibular disorders (DC/TMD) for children and adolescents: An international Delphi study-Part 1-Development of Axis I

Roberto Rongo et al.

Summary: This study used a modified Delphi method to seek international consensus among TMD experts and develop new instruments and adapted DC/TMD diagnostic criteria for children and adolescents with TMD. After three rounds of the Delphi process, consensus was achieved on two adapted DC/TMD protocols for Axis I physical diagnoses in this population. Through international consensus, this study successfully adapted the DC/TMD for evaluating TMD in children and adolescents.

JOURNAL OF ORAL REHABILITATION (2021)

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Article Oncology

Upregulation of antioxidant and autophagy pathways via NRF2 activation protects spinal cord neurons from ozone damage

Cong Zhang et al.

Summary: Ozone therapy can relieve various types of pain but may have neurotoxic effects. This study investigated the role of NRF2 in preventing spinal cord injury caused by ozone overdose and found that activating the p62/NRF2/antioxidant response pathway can protect spinal cord neurons from ozone-induced damage.

MOLECULAR MEDICINE REPORTS (2021)

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Article Immunology

Novel Anti-Cytokine Strategies for Prevention and Treatment of Respiratory Allergic Diseases

Ekaterina O. Gubernatorova et al.

Summary: Asthma is a heterogeneous inflammatory disease characterized by airflow obstruction, wheezing, eosinophilia, and neutrophilia. Targeting different inflammatory patterns with therapeutic antibodies against cytokines has shown promising results. Combining pharmacological inhibition of multiple pathogenic cytokines may be more effective in treating asthma compared to targeting a single cytokine.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Ozone as Modulator of Resorption and Inflammatory Response in Extruded Nucleus Pulposus Herniation. Revising Concepts

Maria de los Angeles Erario et al.

Summary: Ozone therapy for extruded disc herniation acts by modulating the immune response, activating macrophages to phagocytose the extruded nucleus pulposus. It facilitates the transition from an inflammatory phase to a reparative phase of macrophages. Further studies are needed to confirm this mechanism.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of Osteoarthritis

Alessandro de Sire et al.

Summary: Osteoarthritis is a common and painful disease with unknown etiology, likely influenced by multiple factors. Exercise and naturally derived compounds have been suggested to delay OA progression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Rheumatology

A bond between rheumatic diseases and cancer in the elderly: The interleukin-6 pathway

Giuseppe Carlo Iorio et al.

Summary: IL-6 is a key soluble factor involved in immune regulation and inflammation, with targeted therapies showing promise in treating diseases like rheumatoid arthritis and COVID-19. Inhibiting the IL-6 pathway may have a broad impact on inflammatory conditions in elderly individuals, including osteoarthritis and cancer.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2021)

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Article Multidisciplinary Sciences

A potential diagnostic serum immunological marker panel to differentiate between primary and secondary knee osteoarthritis

Sakuni Rankothgedera et al.

Summary: In this study, serum levels of pro-inflammatory cytokines were found to be significantly higher in sKOA patients compared to pKOA patients, with a concurrent decrease in anti-inflammatory cytokine levels. The CombiROC analysis identified specific panels of potential diagnostic markers for differentiating between pKOA and sKOA. This may aid in the development of distinct therapeutic agents for each type of KOA.

PLOS ONE (2021)

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Review Immunology

Raising the 'Good' Oxidants for Immune Protection

Alexia Dumas et al.

Summary: Redox medicine is a new therapeutic concept targeting reactive oxygen species (ROS) and their secondary reaction products. Selective strategies for intervention are needed, especially in inflammatory diseases where source-specific inhibitors of ROS may be more beneficial.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

NF-κB: At the Borders of Autoimmunity and Inflammation

Laura Barnabei et al.

Summary: NF-kappa B transcription factor plays a crucial role in regulating various aspects of innate and adaptive immune functions, serving as a key mediator of immune homeostasis. It is involved in central and peripheral tolerance, as well as the inactivation and destruction of autoreactive immune cells, contributing to immune tolerance. Furthermore, NF-kappa B plays a role in the pathogenesis of autoimmune diseases and has informed new therapeutic approaches for treating these conditions.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

Bei Wang et al.

Summary: The arachidonic acid (AA) pathway is crucial in cardiovascular biology, carcinogenesis, and various inflammatory diseases, producing bioactive mediators that are potential targets for cardiovascular diseases, cancers, and inflammatory diseases. This review summarizes the physiological and pathophysiological importance of AA metabolizing pathways, as well as the molecular mechanisms underlying its actions in CVD and cancer progression. Additionally, clinical studies targeting AA metabolisms in different disease conditions are introduced to explore the role of AA metabolism and potential therapies.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Rehabilitation

Are occlusal splints effective in reducing myofascial pain in patients with muscle-related temporomandibular disorders? A randomized-controlled trial

Andrea Deregibus et al.

Summary: This study suggests that upper Michigan occlusal splint (OS) and mandibular OS did not show significant effects in reducing pain in patients with muscle-related temporomandibular disorders (TMD) over a six-month period.

TURKISH JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION (2021)

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Article Rheumatology

Macrophage migration inhibitory factor may play a protective role in osteoarthritis

Ming Liu et al.

Summary: The study found that MIF expression is lower in osteoarthritis patients, suggesting a potential protective role, serving as a biomarker to differentiate osteoarthritis from other joint disorders.

ARTHRITIS RESEARCH & THERAPY (2021)

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Review Orthopedics

Oxygen-Ozone Therapy for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials

Cristiano Sconza et al.

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2020)

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Article Cell Biology

Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation

Chao Jiang et al.

CELL STRESS & CHAPERONES (2020)

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Article Rehabilitation

Give me a kiss! An integrative rehabilitative training program with motor imagery and mirror therapy for recovery of facial palsy

Teresa Paolucci et al.

EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Modulation of the In Vivo Inflammatory Response by Pro- Versus Anti-Inflammatory Intervertebral Disc Treatments

Carla Cunha et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Orthopedics

Long-term effects of intra-articular oxygen-ozone therapy versus hyaluronic acid in older people affected by knee osteoarthritis: A randomized single-blind extension study

Alessandro de Sire et al.

JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION (2020)

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Article Dentistry, Oral Surgery & Medicine

Distribution of temporomandibular disorders among sleep bruxers and non-bruxers-A polysomnographic study

Mieszko Wieckiewicz et al.

JOURNAL OF ORAL REHABILITATION (2020)

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Review Cell Biology

The Role of Inflammation in the Pathogenesis of Osteoarthritis

Yoke Yue Chow et al.

MEDIATORS OF INFLAMMATION (2020)

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Review Medicine, General & Internal

Osteoarthritis and inflammation: a serious disease with overlapping phenotypic patterns

Francis Berenbaum et al.

POSTGRADUATE MEDICINE (2020)

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In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs

Alexander N. Vaneev et al.

ANALYTICAL CHEMISTRY (2020)

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Article Cell Biology

Anti-inflammatory Effect of Ozone Therapy in an Experimental Model of Rheumatoid Arthritis

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INFLAMMATION (2020)

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Review Medicine, General & Internal

Common Musculoskeletal Disorders in the Elderly: The Star Triad

Marco Alessandro Minetto et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Cell Biology

Evolution of the Knowledge of Free Radicals and Other Oxidants

Sergio Di Meo et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Systemic inflammatory markers in neck pain: A systematic review with meta-analysis

Scott F. Farrell et al.

EUROPEAN JOURNAL OF PAIN (2020)

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Review Physiology

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

Mehdi Sharifi-Rad et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Review Dentistry, Oral Surgery & Medicine

EFFECTIVENESS AND SAFETY OF OZONE THERAPY IN DENTAL CARIES TREATMENT: SYSTEMATIC REVIEW AND META-ANALYSIS

Giovanna Marcilio Santos et al.

JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE (2020)

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Reactive Oxygen Species and Antioxidant Defense in Plants under Abiotic Stress: Revisiting the Crucial Role of a Universal Defense Regulator

Mirza Hasanuzzaman et al.

ANTIOXIDANTS (2020)

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Article Dentistry, Oral Surgery & Medicine

Synovial tissue cytokine profile in disc displacement of the temporomandibular joint

Mattias Ulmner et al.

JOURNAL OF ORAL REHABILITATION (2020)

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Review Rheumatology

Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors

Mats Dehlin et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Review Medicine, General & Internal

The effectiveness of percutaneous injections of ozonotherapy in low back pain

Luciano Timbo Barbosa et al.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2020)

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Article Medicine, Research & Experimental

Effectiveness of ozone injection therapy in temporomandibular disorders

Sheila Haghighat et al.

ADVANCED BIOMEDICAL RESEARCH (2020)

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Article Dentistry, Oral Surgery & Medicine

Associations of Psychologic Factors with Multiple Chronic Overlapping Pain Conditions

Roger B. Fillingim et al.

JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE (2020)

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Review Medicine, General & Internal

Ozone injection therapy for intervertebral disc herniation

Filippo Migliorini et al.

BRITISH MEDICAL BULLETIN (2020)

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Article Immunology

Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported

Marianno Franzini et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Medicine, General & Internal

Healthcare utilisation and costs for temporomandibular disorders: a descriptive, cross-sectional study

Hyejin Seo et al.

BMJ OPEN (2020)

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Review Rheumatology

Gender and Ethnic Inequities in Gout Burden and Management

Andrea Garcia Guillen et al.

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2020)

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Review Cell Biology

Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

Catia Scassellati et al.

AGEING RESEARCH REVIEWS (2020)

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Article Biochemistry & Molecular Biology

Ozone Therapy Attenuates NF-κB-Mediated Local Inflammatory Response and Activation of Th17 Cells in Treatment for Psoriasis

Jinrong Zeng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Article Pharmacology & Pharmacy

Comparison of Two Different Ozone Injection Sites for Knee Osteoarthritis, Tibio-femoral Joint versus Supra-patellar Recess: An Open Randomized Clinical Trial

Masoud Hashemi et al.

JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL (2020)

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Article Biochemical Research Methods

Electrochemical monitoring of reactive oxygen/nitrogen species and redox balance in living cells

Marco Malferrari et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2019)

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Review Biochemistry & Molecular Biology

Molecular Relationships among Obesity, Inflammation and Intervertebral Disc Degeneration: Are Adipokines the Common Link?

Clara Ruiz-Fernandez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Pharmacology & Pharmacy

The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases

Luca Antonioli et al.

PHARMACOLOGICAL REVIEWS (2019)

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Review Biochemistry & Molecular Biology

The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure

Mirco Galie et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Rehabilitation

Comparison of Platelet Rich Plasma and Oxygen Ozone Injections for Knee Osteoarthritis: A Systematic Review

Richard Haydt et al.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2019)

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Review Biochemistry & Molecular Biology

Cytokines in Inflammatory Disease

Shinwan Kany et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Rheumatology

Mechanoflammation in osteoarthritis pathogenesis

Tonia L. Vincent

SEMINARS IN ARTHRITIS AND RHEUMATISM (2019)

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Article Dentistry, Oral Surgery & Medicine

Long-term Effectiveness of Occlusal Splint Therapy Compared to Placebo in Patients with Chronic Temporomandibular Disorders

Ema Vrbanovic et al.

ACTA STOMATOLOGICA CROATICA (2019)

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Article Veterinary Sciences

The Investigation of the Effect of Ozone Therapy on Gout in Experimental Rat Models

Ali Bilge et al.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI (2019)

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Article Orthopedics

Interesting effectiveness of ozone injection for carpal tunnel syndrome treatment: a randomized controlled trial

Mohammad Hasan Bahrami et al.

ORTHOPEDIC RESEARCH AND REVIEWS (2019)

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Article Dentistry, Oral Surgery & Medicine

Management of pain in TMD patients: Bio-oxidative ozone therapy versus occlusal splints

Tamer Celakil et al.

CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE (2019)

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Evaluation of the Short-Term Efficacy of Transdermal Ozone Therapy in Turkish Patients with Internal Derangement of the Temporomandibular Joint

Oznur Ozalp et al.

PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA (2019)

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Blocking fibrotic signaling in fibroblasts from patients with carpal tunnel syndrome

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Effect of Particulate Matter Air Pollution on Cardiovascular Oxidative Stress Pathways

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The effects of ultrasound-guided corticosteroid injection compared to oxygen-ozone (O2-O3) injection in patients with knee osteoarthritis: a randomized controlled trial

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CLINICAL RHEUMATOLOGY (2018)

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Ozone therapy for the treatment of chronic wounds: A systematic review

Erin Fitzpatrick et al.

INTERNATIONAL WOUND JOURNAL (2018)

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Article Dentistry, Oral Surgery & Medicine

Prevalence of temporomandibular disorders discovered incidentally during routine dental examination using the Research Diagnostic Criteria for Temporomandibular Disorders

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ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY (2018)

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Therapeutic Effect of Medical Ozone on Lumbar Disc Herniation

Tong Niu et al.

MEDICAL SCIENCE MONITOR (2018)

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Review Biology

Medical ozone therapy as a potential treatment modality for regeneration of damaged articular cartilage in osteoarthritis

Sello Lebohang Manoto et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2018)

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Article Dentistry, Oral Surgery & Medicine

Reliability and Validity of the Diagnostic Criteria for Temporomandibular Disorders Axis I in Clinical and Research Settings: A Critical Appraisal

Michel H. Steenks et al.

JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE (2018)

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Review Orthopedics

The roles of inflammatory mediators and immunocytes in tendinopathy

Chenqi Tang et al.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2018)

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Article Orthopedics

Triamcinolone Acetonide affects TGF-β signaling regulation of fibrosis in idiopathic carpal tunnel syndrome

Tai-Hua Yang et al.

BMC MUSCULOSKELETAL DISORDERS (2018)

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Review Medicine, General & Internal

Ozone Therapy in Knee Osteoarthritis: A Systematic Review

Tiago Costa et al.

ACTA MEDICA PORTUGUESA (2018)

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Editorial Material Physiology

Editorial: The Physiology of Inflammation-The Final Common Pathway to Disease

Alexandrina Ferreira Mendes et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Review Clinical Neurology

An investigation into the efficacy of intra-articular ozone (O-2-O-3) injection in patients with knee osteoarthritis: a systematic review and meta-analysis

Seyed Ahmad Raeissadat et al.

JOURNAL OF PAIN RESEARCH (2018)

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Review Radiology, Nuclear Medicine & Medical Imaging

Facet joint syndrome: from diagnosis to interventional management

Romain Perolat et al.

INSIGHTS INTO IMAGING (2018)

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Review Agriculture, Dairy & Animal Science

The crucial roles of inflammatory mediators in inflammation: A review

L. A. Abdulkhaleq et al.

VETERINARY WORLD (2018)

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Review Rheumatology

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis

Terence W. O'Neill et al.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2018)

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Review Rehabilitation

Cytokine Involvement in Biological Inflammation Related to Degenerative Disorders of the Intervertebral Disk: A Narrative Review

Christopher M. De Geer

JOURNAL OF CHIROPRACTIC MEDICINE (2018)

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Review Medicine, Research & Experimental

Clinical utility of ozone therapy for musculoskeletal disorders

Omar Seyam et al.

MEDICAL GAS RESEARCH (2018)

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Article Dentistry, Oral Surgery & Medicine

Frequency of temporomandibular disorder signs and symptoms among call center employees

Alp Saruhanoglu et al.

CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE (2017)

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Article Orthopedics

Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options

Tahir Mutlu Duymus et al.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2017)

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Article Pharmacology & Pharmacy

Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients

Livan Delgado-Roche et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

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Article Dentistry, Oral Surgery & Medicine

Effect of high-frequency bio-oxidative ozone therapy for masticatory muscle pain: a double-blind randomised clinical trial

T. Celakil et al.

JOURNAL OF ORAL REHABILITATION (2017)

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Article Medicine, General & Internal

Effects of ozone on the pain and disability in patients with failed back surgery syndrome

Danilo Costa Barbosa et al.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2017)

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Article Orthopedics

Increased stiffness of median nerve in systemic sclerosis

Ilker Yagci et al.

BMC MUSCULOSKELETAL DISORDERS (2017)

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Review Medicine, Research & Experimental

Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility

Noel L. Smith et al.

MEDICAL GAS RESEARCH (2017)

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Review Orthopedics

Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis

Susan Armijo-Olivo et al.

PHYSICAL THERAPY (2016)

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Review Biochemistry & Molecular Biology

Mechanisms of the acute effects of inhaled ozone in humans

Philip A. Bromberg

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)

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Review Biochemistry & Molecular Biology

ROS/oxidative stress signaling in osteoarthritis

Panagiotis Lepetsos et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

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Review Endocrinology & Metabolism

Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges

Maryam Rahmati et al.

BONE (2016)

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Review Biochemistry & Molecular Biology

Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review

Sergio Varela Kellesarian et al.

CYTOKINE (2016)

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Article Pharmacology & Pharmacy

Medical ozone increases methotrexate clinical response and improves cellular redox balance in patients with rheumatoid arthritis

Olga Sonia Leon Fernandez et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

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Article Biochemistry & Molecular Biology

Effect of ozone on vascular endothelial growth factor (VEGF) and related inflammatory cytokines in rats with diabetic retinopathy

T. Y. Xie et al.

GENETICS AND MOLECULAR RESEARCH (2016)

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Article Orthopedics

Temporomandibular dysfunction and risk factors for anxiety and depression

Demirhan Diracoglu et al.

JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION (2016)

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Review Dentistry, Oral Surgery & Medicine

Painful Temporomandibular Disorder: Decade of Discovery from OPPERA Studies

G. D. Slade et al.

JOURNAL OF DENTAL RESEARCH (2016)

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Article Medicine, Research & Experimental

IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells

Jing-kun Li et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2016)

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Editorial Material Biotechnology & Applied Microbiology

Biomarkers of (osteo)arthritis

Ali Mobasheri et al.

BIOMARKERS (2015)

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Article Medicine, General & Internal

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

Theo Vos et al.

LANCET (2015)

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Article Geriatrics & Gerontology

Oxidative stress-dependent changes in immune responses and cell death in the substantia nigra after ozone exposure in rat

Selva Rivas-Arancibia et al.

Frontiers in Aging Neuroscience (2015)

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Article Rheumatology

Inflammatory Pathways in Knee Osteoarthritis: Potential Targets for Treatment

David Bar-Or et al.

CURRENT RHEUMATOLOGY REVIEWS (2015)

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Editorial Material Rheumatology

Musculoskeletal disorders and the Global Burden of Disease study

Kjersti Storheim et al.

ANNALS OF THE RHEUMATIC DISEASES (2014)

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Article Clinical Neurology

An observational retrospective/horizontal study to compare oxygen-ozone therapy and/or global postural re-education in complicated chronic low back pain

Dario Apuzzo et al.

FUNCTIONAL NEUROLOGY (2014)

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Article Medicine, General & Internal

Effects of High-Frequency Bio-Oxidative Ozone Therapy in Temporomandibular Disorder-Related Pain

Mansur Dogan et al.

MEDICAL PRINCIPLES AND PRACTICE (2014)

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Review Pharmacology & Pharmacy

Targeting CCL5 in inflammation

Rafael Elias Marques et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2013)

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Review Biochemistry & Molecular Biology

Inflammatory mediators in the pathogenesis of periodontitis

Tulay Yucel-Lindberg et al.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2013)

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Article Clinical Neurology

Psychological Factors Associated With Development of TMD: The OPPERA Prospective Cohort Study

Roger B. Fillingim et al.

JOURNAL OF PAIN (2013)

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Article Clinical Neurology

Effects of ozone applied by spinal endoscopy in patients with chronic pain related to failed back surgery syndrome: a pilot study

Francisco Neuton de Oliveira Magalhaes et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2013)

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Article Biology

Psychological stress alters the ultrastructure and increases IL-1β and TNF-α in mandibular condylar cartilage

Xin Lv et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2012)

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Article Dentistry, Oral Surgery & Medicine

Evaluation of the short-term effectiveness of education versus an occlusal splint for the treatment of myofascial pain of the jaw muscles

Ambra Michelotti et al.

JOURNAL OF THE AMERICAN DENTAL ASSOCIATION (2012)

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Article Geriatrics & Gerontology

Aging, Atherosclerosis, and IGF-1

Yusuke Higashi et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2012)

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Article Dentistry, Oral Surgery & Medicine

Role of intra-articular ozone gas injection in the management of internal derangement of the temporomandibular joint

Emad T. Daif

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY (2012)

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Article Medicine, General & Internal

The effects of ozone therapy and coenzyme Q10 combination on oxidative stress markers in healthy subjects

M. Inal et al.

IRISH JOURNAL OF MEDICAL SCIENCE (2011)

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Article Biochemistry & Molecular Biology

Interleukin-27 and Interferon-γ Are Involved in Regulation of Autoimmune Arthritis

Rajesh Rajaiah et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Review Dentistry, Oral Surgery & Medicine

Research diagnostic criteria for temporomandibular disorders: a systematic review of axis I epidemiologic findings

Daniele Manfredini et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY (2011)

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Review Medicine, Research & Experimental

Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?

Masaru Sagai et al.

MEDICAL GAS RESEARCH (2011)

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Article Pharmacology & Pharmacy

Effects of Ozone Blood Treatment on the Metabolite Profile of Human Blood

Valter Travagli et al.

INTERNATIONAL JOURNAL OF TOXICOLOGY (2010)

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Review Biotechnology & Applied Microbiology

Subcellular targeting strategies for drug design and delivery

Lawrence Rajendran et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

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Article Clinical Neurology

Intramuscular Oxygen-Ozone Therapy in the Treatment of Acute Back Pain With Lumbar Disc Herniation A Multicenter, Randomized, Double-Blind, Clinical Trial of Active and Simulated Lumbar Paravertebral Injection

Marco Paoloni et al.

SPINE (2009)

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Article Dentistry, Oral Surgery & Medicine

Effect of aqueous ozone on the NF-κB system

K. C. Huth et al.

JOURNAL OF DENTAL RESEARCH (2007)

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Review Medicine, Research & Experimental

Scientific and medical aspects of ozone therapy. State of the art

VA Bocci

ARCHIVES OF MEDICAL RESEARCH (2006)

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Article Dentistry, Oral Surgery & Medicine

Aggrecanase analysis temporomandibular of synovial fluid of joint disorders

K Yoshida et al.

ORAL DISEASES (2005)

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Article Dentistry, Oral Surgery & Medicine

Expression of matrix metalloproteinase-2 and-9 in synovial fluid of the temporomandibular joint accompanied by anterior disc displacement

A Tanaka et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2001)

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Article Biochemistry & Molecular Biology

Effect of ozone treatment on reactive oxygen species and adenosine production during hepatic ischemia-reperfusion

C Peralta et al.

FREE RADICAL RESEARCH (2000)

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