期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 64, 期 27, 页码 5525-5530出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b02210
关键词
flavonoids; biotransformation; yeast; Rhodotorula glutinis; hydroxylation; regioselectivity
资金
- Wroclaw Centre of Biotechnology, The Leading National Research Centre Programme (KNOW)
Natural flavonoids, such as naringenin, hesperetin, chrysin, apigenin, luteolin, quercetin, epicatechin, and biochanin A, were subjected to microbiological transformations by Rhodotorula glutinis. Yeast was able to regioselectively C-8 hydroxylate hesperetin, luteolin, and chrysin. Naringenin was transformed to 8- and 6-hydroxyderivatives. Quercetin, epicatechin, and biochanin A did not undergo biotransformation. A metabolic pathway for the degradation of chrysin has been elucidated. The metabolism of chrysin proceeds via an initial C-8 hydroxylation to norwogonin, followed by A-ring cleavage to 4-hydroxy-6-phenyl-2H-pyran-2-one.
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