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Cerebral Cavernous Malformation Pathogenesis: Investigating Lesion Formation and Progression with Animal Models

期刊

出版社

MDPI
DOI: 10.3390/ijms23095000

关键词

cerebrovascular malformation; KRIT1; CCM2; PDCD10; hemorrhagic lesions; CCM animal models; RhoA kinase inhibition

资金

  1. NIH Early Stage Training in the Neurosciences Training Grant [T32-NS076401, R21-NS111205]

向作者/读者索取更多资源

Cerebral cavernous malformation is a cerebromicrovascular disease with significant impact on the population, leading to severe symptoms and complications. Understanding the function of CCM proteins is crucial for unraveling the disease pathogenesis and developing treatment strategies. Animal models play a key role in studying CCM pathogenesis and therapeutic development.
Cerebral cavernous malformation (CCM) is a cerebromicrovascular disease that affects up to 0.5% of the population. Vessel dilation, decreased endothelial cell-cell contact, and loss of junctional complexes lead to loss of brain endothelial barrier integrity and hemorrhagic lesion formation. Leakage of hemorrhagic lesions results in patient symptoms and complications, including seizures, epilepsy, focal headaches, and hemorrhagic stroke. CCMs are classified as sporadic (sCCM) or familial (fCCM), associated with loss-of-function mutations in KRIT1/CCM1, CCM2, and PDCD10/CCM3. Identifying the CCM proteins has thrust the field forward by (1) revealing cellular processes and signaling pathways underlying fCCM pathogenesis, and (2) facilitating the development of animal models to study CCM protein function. CCM animal models range from various murine models to zebrafish models, with each model providing unique insights into CCM lesion development and progression. Additionally, these animal models serve as preclinical models to study therapeutic options for CCM treatment. This review briefly summarizes CCM disease pathology and the molecular functions of the CCM proteins, followed by an in-depth discussion of animal models used to study CCM pathogenesis and developing therapeutics.

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