期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms23095162
关键词
multiple sclerosis; proteomics; biomarker; pathogenesis; disease activity; progression; conversion; disease modifying therapy
资金
- Hungarian Scientific Research Fund (Orszagos Tudomanyos Kutatasi Alapprogram) [OTKA-138125-K]
Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system and approximately 2.8 million people worldwide. Despite advancements in personalized medicine, there are still many unknown aspects of the disease that require further research. Proteomics, a rapidly evolving discipline, has shown promise in identifying molecular biomarkers for the diagnosis, differential diagnosis, and therapy of MS. This review highlights the utility of proteomics in MS research and its potential for important findings.
Multiple sclerosis (MS) is the inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS) that affects approximately 2.8 million people worldwide. In the last decade, a new era was heralded in by a new phenotypic classification, a new diagnostic protocol and the first ever therapeutic guideline, making personalized medicine the aim of MS management. However, despite this great evolution, there are still many aspects of the disease that are unknown and need to be further researched. A hallmark of these research are molecular biomarkers that could help in the diagnosis, differential diagnosis, therapy and prognosis of the disease. Proteomics, a rapidly evolving discipline of molecular biology may fulfill this dire need for the discovery of molecular biomarkers. In this review, we aimed to give a comprehensive summary on the utility of proteomics in the field of MS research. We reviewed the published results of the method in case of the pathogenesis of the disease and for biomarkers of diagnosis, differential diagnosis, conversion of disease courses, disease activity, progression and immunological therapy. We found proteomics to be a highly effective emerging tool that has been providing important findings in the research of MS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据