期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms23052591
关键词
DAMPs; endophthalmitis; uveitis; glaucoma; ocular cancer; ischemic retinopathies; diabetic retinopathy; age-related macular degeneration; proliferative vitreoretinopathy; inherited retinal disorders
资金
- National Eye Institute, NIH, Bethesda, Maryland [RO1EY029795]
- Children's Wisconsin CRI Multi-Year Grant, Children's Research Institute, Milwaukee, WI
- National Center for Research Resources, NIH [C06RR016511]
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules associated with retinal diseases. They can activate the innate immune system and have roles in both protective and pathological inflammation. However, the role of DAMPs in retinal disorders is not well understood and further research is needed.
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from the extracellular and intracellular space of damaged tissue or dead cells. Recent evidence indicates that DAMPs are associated with the sterile inflammation caused by aging, increased ocular pressure, high glucose, oxidative stress, ischemia, mechanical trauma, stress, or environmental conditions, in retinal diseases. DAMPs activate the innate immune system, suggesting their role to be protective, but may promote pathological inflammation and angiogenesis in response to the chronic insult or injury. DAMPs are recognized by specialized innate immune receptors, such as receptors for advanced glycation end products (RAGE), toll-like receptors (TLRs) and the NOD-like receptor family (NLRs), and purine receptor 7 (P2X7), in systemic diseases. However, studies describing the role of DAMPs in retinal disorders are meager. Here, we extensively reviewed the role of DAMPs in retinal disorders, including endophthalmitis, uveitis, glaucoma, ocular cancer, ischemic retinopathies, diabetic retinopathy, age-related macular degeneration, rhegmatogenous retinal detachment, proliferative vitreoretinopathy, and inherited retinal disorders. Finally, we discussed DAMPs as biomarkers, therapeutic targets, and therapeutic agents for retinal disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据