4.7 Review

Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to Bone Disorders

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Summary: Lysophosphatidic acid (LPA) plays an important role in rheumatoid arthritis-associated pain, and its signaling affects joint inflammation and neuropathic pain. In a experimental model, neutralizing antibody and receptor inhibitor reverse pain-like behavior without affecting joint inflammation. LPA synthesizing enzyme is upregulated in dorsal root ganglia (DRG) neurons, and Lpar1 receptor deficiency blocks pronociceptive neurochemical changes in DRG. LPA regulates pain-like behavior through LPA(1) receptor on satellite glia cells (SGCs) in DRG.

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