期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms23063202
关键词
receptive field; retina; retinal ganglion cells (RGCs); Nyx(nob); congenital nystagmus; CSNB; green-light preferring RGCs; UV-light preferring RGCs
资金
- van Hessen - Israels Fund of the Friends Foundation of the Netherlands Institute of Neuroscience, EU [UT2016-13, UT 20120-14]
- Friends Foundation of the Netherlands Institute of Neuroscience Foundation
Contrary to our expectation, receptive field sizes in the Nyx(nob) retina had decreased for green-light preferring RGCs relative to wild-type mice, while the receptive fields of UV-light preferring RGCs were larger in both WT and Nyx(nob) mice.
Patients with congenital nystagmus, involuntary eye movements, often have a reduced visual acuity. Some of these patients have a retinal-specific mutation in the protein nyctalopin, which is also present in the Nyx(nob) mouse. In these mice, retinal ganglion cells (RGCs) have oscillatory activity, which leads to expanded axonal projections towards the dLGN and consequently to a desegregation of retinal projections to the brain. In this study, we investigate whether the receptive fields of Nyx(nob) RGCs have also expanded by measuring the size of their receptive fields using MEA recordings. Contrary to our expectation, relative to wild-type (WT) mice we found receptive field sizes in the Nyx(nob) retina had not increased but instead had decreased for green-light preferring RGCs. Additionally, we also found the receptive fields of UV-light preferring RGCs are larger than green-light preferring RGCs in both WT and Nyx(nob) mice.
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