期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms23116079
关键词
neuroimaging; multimodal imaging; brain imaging; Alzheimer's disease; early diagnosis; preclinical biomarkers
资金
- NIH/NIBIB [R01EB022230]
- NIH/NHLBI [R01HL143020]
- Creative Materials Discovery Program through the National Research Foundation of Korea [2019M3D1A1078938, 2022R1A2B5B01002377]
- Korea Health Technology RD Project [HI19C1085]
- National Research Foundation of Korea [2022R1A2B5B01002377] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Alzheimer's disease is a neurodegenerative disease with no effective treatment options yet. Early diagnosis is essential for more effective therapy, and brain imaging techniques can serve as a valuable tool in this process.
Alzheimer's disease (AD) is a neurodegenerative disease causing progressive cognitive decline until eventual death. AD affects millions of individuals worldwide in the absence of effective treatment options, and its clinical causes are still uncertain. The onset of dementia symptoms indicates severe neurodegeneration has already taken place. Therefore, AD diagnosis at an early stage is essential as it results in more effective therapy to slow its progression. The current clinical diagnosis of AD relies on mental examinations and brain imaging to determine whether patients meet diagnostic criteria, and biomedical research focuses on finding associated biomarkers by using neuroimaging techniques. Multiple clinical brain imaging modalities emerged as potential techniques to study AD, showing a range of capacity in their preciseness to identify the disease. This review presents the advantages and limitations of brain imaging modalities for AD diagnosis and discusses their clinical value.
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