期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ijms23084208
关键词
inflammasome; NLRP3; glomerulonephritis; innate immunity
资金
- Instituto de Salud Carlos III [CM21/00170]
- European Social Fund (ESF investing in your future)
- Ministerio de Ciencia, Innovacion y Universidades (Madrid, Spain) [FIS-ISCIII PI20/00812]
- FEDER funds/European Regional Development Fund-a way to build Europe [FI21/00067]
This review describes the characteristics, activation mechanisms, regulation, and functions of different inflammasomes, and discusses the latest findings on the role of the inflammasome in several glomerulonephritis from in vitro, animal, and human studies.
The inflammasome is an immune multiprotein complex that activates pro-caspase 1 in response to inflammation-inducing stimuli and it leads to IL-1 beta and IL-18 proinflammatory cytokine production. NLRP1 and NLRP3 inflammasomes are the best characterized and they have been related to several autoimmune diseases. It is well known that the kidney expresses inflammasome genes, which can influence the development of some glomerulonephritis, such as lupus nephritis, ANCA glomerulonephritis, IgA nephropathy and anti-GBM nephropathy. Polymorphisms of these genes have also been described to play a role in autoimmune and kidney diseases. In this review, we describe the main characteristics, activation mechanisms, regulation and functions of the different inflammasomes. Moreover, we discuss the latest findings about the role of the inflammasome in several glomerulonephritis from three different points of view: in vitro, animal and human studies.
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