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Quest for Quality in Translational Stroke Research-A New Dawn for Neuroprotection?

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Summary: Exosomes enriched with the MiR-17-92 cluster derived from multipotent mesenchymal stromal cells (MSCs) can enhance functional recovery after transient stroke, potentially by promoting axonal extension and myelination. This enhancement in axon-myelin remodeling may be mediated through the activation of the PI3K/Akt/mTOR pathway induced by downregulation of PTEN.

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Summary: The lack of a powerful animal model for human ischemic stroke may be a major reason for the failure to develop successful neuroprotective drugs. Innovative animal models, better techniques in functional outcome assessment, and improved experimental designs are needed to develop truly beneficial drugs for human ischemic stroke.

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Summary: Preconditioning of MSCs with lithium enhances the therapeutic potential of EVs, specifically Li-EVs, which show increased resistance against hypoxic injury and improved neurological recovery in poststroke models. Additionally, Li-EVs modify the contents of miRNAs to inhibit TLR4 signaling pathway and reduce poststroke cerebral inflammation, providing acute neuroprotection and enhanced neurological recovery.

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Anna M. Planas

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Eric S. Donkor

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Aileen J. F. King

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NXY-059 for the treatment of acute ischemic stroke

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NXY-059 - Brain or vessel protection

Michalis Papadakis et al.

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The rise and fall of NMDA antagonists for ischemic. stroke

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