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New Insights into TETs in Psychiatric Disorders

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Summary: The study demonstrates the critical role of TET3 in the brain, highlighting its high expression in neurons and oligodendrocytes and involvement in molecular regulation of hippocampal-dependent functions. Deletion of TET3 in adult mature neurons resulted in increased anxiety-like behavior and impaired spatial orientation, suggesting the importance of epigenetic modifications in modulating brain functions and potentially the development of neurological disorders.

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Summary: Research has found that there are two different isoforms of the Tet1 gene in the adult mouse brain, with Tet1(S) being highly enriched in neurons and Tet1(FL) more abundant in glia, suggesting their roles are at least partially cell type-specific. Using neuron-specific molecular tools, it has been demonstrated that each Tet1 isoform serves a distinct role in the mammalian brain.

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Edyta Reszka et al.

Summary: Sparse studies suggest that global DNA methylation biomarkers may be linked to bipolar disorder, anxiety, and major depression disorder. This study found higher levels of 5-mC, Alu, and LINE-1 methylation in women with depression, as well as a lower level of 5-hmC. BD type I patients exhibited the highest level of 5-mC among all women with depression.

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Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring

Wen Chen et al.

Summary: Fetal growth restriction impairs cognitive function in later life by decreasing hippocampal neurogenesis through reduced proliferation of neural stem cells. The long-term decrease in Tet1/Notch signaling in hippocampal NSCs contributes to impaired neurogenesis following FGR, suggesting potential targets for intervention of FGR-related cognitive disorders.

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Sarah Moyon et al.

Summary: The study reveals that DNA hydroxymethylase TET1 regulates myelin repair in adult mice, but is defective with aging. Furthermore, deletion of TET1 results in decreased repair of demyelinated lesions and altered expression of genes related to neuro-glial communication.

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Roles of ten-eleven translocation family proteins and their O-linked β-N-acetylglucosaminylated forms in cancer development

Hong-Jiao Li et al.

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Joy N. Ismail et al.

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TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn

Raquel Montalban-Loro et al.

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Zhixiong Sun et al.

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Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice

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Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

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Genome-wide disruption of 5-hydroxymethylcytosine in a mouse model of autism

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