4.7 Review

Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson's Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

LRRK2-G2019S mice display alterations in glutamatergic synaptic transmission in midbrain dopamine neurons

Olga Skiteva et al.

Summary: This study reveals alterations in glutamatergic synaptic transmission in DA neurons of the SNc and VTA before the onset of motor impairments in the LRRK2-G2019S mouse model of PD.

JOURNAL OF NEUROCHEMISTRY (2022)

Review Neurosciences

LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease

Eunice Eun Seo Chang et al.

Summary: Mutations in the LRRK2 gene are common causes of Parkinson's disease and suggest that LRRK2 could be a therapeutic target. LRRK2 mutant mice models show pathological similarities to early-stage Parkinson's disease, providing important insights into the mechanisms of the disease.

TRANSLATIONAL NEURODEGENERATION (2022)

Editorial Material Neurosciences

BMAA, Neurodegeneration, and Neuroprotection

Paul Alan Cox

Summary: Studies in this volume explore the various forms of BMAA and its potential neurotoxic risks from environmental exposures. Discrepancies in the detection and quantification of BMAA across different laboratories may stem from the use of varying analytical methods.

NEUROTOXICITY RESEARCH (2021)

Article Neurosciences

α-Synuclein Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons, an Effect Partly Reversed by the KATP Channel Inhibitor Glibenclamide

E. Hill et al.

Summary: The study indicates that oligomeric alpha-synuclein plays a significant role in Parkinson's disease, leading to functional impairment of dopaminergic neurons. Preincubation with the ATP-sensitive K+ channel inhibitor glibenclamide can effectively reduce the impact of alpha-syn aggregates.

ENEURO (2021)

Article Multidisciplinary Sciences

Disruption of mitochondrial complex I induces progressive parkinsonism

Patricia Gonzalez-Rodriguez et al.

Summary: Loss of functional mitochondrial complex I in dopaminergic neurons can lead to a shift in metabolism in mice, causing Parkinson's disease-like symptoms. This study challenges the traditional paradigm of Parkinson's disease by showing that dysfunction of mitochondrial complex I alone is sufficient to cause progressive parkinsonism.

NATURE (2021)

Review Neurosciences

Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases? A Response to a Critical Review of the BMAA Hypothesis

R. A. Dunlop et al.

Summary: Chernoff et al. criticize the hypothesis of BMAA exposure as a risk factor for neurodegenerative diseases, pointing out errors in their critique such as selective citation of literature and misattribution of methods. Although uncertainties exist in the research field of chronic exposure to BMAA causing neurodegenerative diseases, an increasing body of evidence suggests this possibility.

NEUROTOXICITY RESEARCH (2021)

Article Neurosciences

Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of Ih current in VTA

Sebastian Luca D'Addario et al.

Summary: The study revealed that disrupting mother-pups bond may induce resilience to depression-like phenotype in adult mice, and demonstrated a link between electrophysiological modifications of dopaminergic neurons in the VTA and behavioral resilience using in vivo and ex vivo pharmacological approaches.

NEUROBIOLOGY OF STRESS (2021)

Article Biochemistry & Molecular Biology

Early Dysfunction of Substantia Nigra Dopamine Neurons in the ParkinQ311X Mouse

Maria Regoni et al.

Summary: Mutations in the PARK2 gene cause ARJP, a neurodegenerative disease with no current therapy. The transgenic mouse model ParkinQ311X mimics key features of ARJP, making it a useful tool for studying neurodegenerative mechanisms and screening potential neuroprotective drugs.

BIOMEDICINES (2021)

Review Biochemistry & Molecular Biology

Hidden phenotypes of PINK1/Parkin knockout mice

Swagatika Paul et al.

Summary: Although PINK1 and Parkin KO mouse models do not faithfully recapitulate early onset forms of Parkinson's disease, they have provided insights into the roles of PINK1 and Parkin in mitochondrial quality control and function in various tissues beyond the brain. Despite being generated over a decade ago, these models are still being used to creatively elucidate the cell-type specific functions of these proteins. Recently, these mouse models have revealed the contributions of these proteins to innate immunity and cancer phenotypes.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)

Article Clinical Neurology

Dopamine-dependent early synaptic and motor dysfunctions induced by a-synuclein in the nigrostriatal circuit

Alessandro Tozzi et al.

Summary: The study identified that alpha-synuclein disrupts dopamine system and striatal synaptic plasticity in early stages of Parkinson's disease. Subchronic treatment with L-DOPA was able to rescue alpha-synuclein-induced alterations, showing the critical role of dysfunctional dopamine system in disease progression.
Review Neurosciences

DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application

Maoxin Huang et al.

Summary: Neurodegenerative diseases pose a significant health threat to humans due to selective and progressive neuronal loss. Research indicates that these diseases share common features, mechanisms, and genetic or protein abnormalities. Genetic defects and alterations in disease-related proteins can lead to the occurrence of neurodegenerative diseases.

PROGRESS IN NEUROBIOLOGY (2021)

Review Biochemistry & Molecular Biology

Advancement in the modelling and therapeutics of Parkinson's disease

Sachchida Nand Rai et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2020)

Review Biotechnology & Applied Microbiology

Mucuna pruriens in Parkinson's and in some other diseases: recent advancement and future prospective

Sachchida Nand Rai et al.

3 BIOTECH (2020)

Review Pharmacology & Pharmacy

The Potential of L-Type Calcium Channels as a Drug Target for Neuroprotective Therapy in Parkinson's Disease

Birgit Liss et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

Review Physiology

The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area

Stephanie C. Gantz et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

Review Clinical Neurology

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration

Veronica Ghiglieri et al.

FRONTIERS IN NEUROLOGY (2018)

Article Neurosciences

On the properties of identified dopaminergic neurons in the mouse substantia nigra and ventral tegmental area

Paraskevi Krashia et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants

Irene Lopez-Fabuel et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

Article Neurosciences

Current Concepts on the Physiopathological Relevance of Dopaminergic Receptors

Ada Ledonne et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism

Paul D. Dodson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biology

Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain

Paul Alan Cox et al.

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2016)

Article Clinical Neurology

A new role for -synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

Cristina Guardia-Laguarta et al.

MOVEMENT DISORDERS (2015)

Review Neurosciences

Dysfunctional HCN ion channels in neurological diseases

Jacopo C. DiFrancesco et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Article Neurosciences

alpha-Synuclein Is Localized to Mitochondria-Associated ER Membranes

Cristina Guardia-Laguarta et al.

JOURNAL OF NEUROSCIENCE (2014)

Review Anatomy & Morphology

Molecular determinants of selective dopaminergic vulnerability in Parkinson's disease: an update

Lars Brichta et al.

FRONTIERS IN NEUROANATOMY (2014)

Article Biochemistry & Molecular Biology

Oxidation and nitration of α-synuclein and their implications in neurodegenerative diseases

Cecilia Chavarria et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2013)

Article Neurosciences

Dual effects of L-DOPA on nigral dopaminergic neurons

Ezia Guatteo et al.

EXPERIMENTAL NEUROLOGY (2013)

Review Neurosciences

Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

Maria Xilouri et al.

MOLECULAR NEUROBIOLOGY (2013)

Review Neurosciences

The many faces of alpha-synuclein: from structure and toxicity to therapeutic target

Hilal A. Lashuel et al.

NATURE REVIEWS NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

Stephanie Janezic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Potential role of α-synuclein in neurodegeneration: studies in a rat animal model

George Stoica et al.

JOURNAL OF NEUROCHEMISTRY (2012)

Article Clinical Neurology

Living on the edge with too many mouths to feed: Why dopamine neurons die

J. Paul Bolam et al.

MOVEMENT DISORDERS (2012)

Review Neurosciences

DOPAMINE RELEASE IN THE BASAL GANGLIA

M. E. Rice et al.

NEUROSCIENCE (2011)

Review Neurosciences

L-DOPA: A scapegoat for accelerated neurodegeneration in Parkinson's disease?

Janusz Lipski et al.

PROGRESS IN NEUROBIOLOGY (2011)

Article Pharmacology & Pharmacy

Trace amines depress D2-autoreceptor-mediated responses on midbrain dopaminergic cells

Ada Ledonne et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Article Neurosciences

Hyperexcitable Substantia Nigra Dopamine Neurons in PINK1- and HtrA2/Omi-Deficient Mice

Matthew W. Bishop et al.

JOURNAL OF NEUROPHYSIOLOGY (2010)

Article Multidisciplinary Sciences

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

Jaime N. Guzman et al.

NATURE (2010)

Article Multidisciplinary Sciences

α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

Jacqueline Burre et al.

SCIENCE (2010)

Review Clinical Neurology

Levodopa in the treatment of Parkinson's disease

A. H. V. Schapira et al.

EUROPEAN JOURNAL OF NEUROLOGY (2009)

Review Clinical Neurology

The scientific and clinical basis for the treatment of Parkinson disease (2009)

C. Warren Olanow et al.

NEUROLOGY (2009)

Article Pharmacology & Pharmacy

Paraquat inhibits postsynaptic AMPA receptors on dopaminergic neurons in the substantia nigra pars compacta

Chun-Yao Lee et al.

BIOCHEMICAL PHARMACOLOGY (2008)

Article Multidisciplinary Sciences

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

Yufeng Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

The PINK1/Parkin pathway regulates mitochondrial morphology

Angela C. Poole et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Neurosciences

Localization of α-synuclein to mitochondria within midbrain of mice

Wen-Wei Li et al.

NEUROREPORT (2007)

Article Multidisciplinary Sciences

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

Tohru Kitada et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

Mats I. Ekstrand et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease

Todd B. Sherer et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Article Multidisciplinary Sciences

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

RH Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biochemistry & Molecular Biology

Does α-synuclein modulate dopaminergic synaptic content and tone at the synapse?

A Sidhu et al.

FASEB JOURNAL (2004)

Article Clinical Neurology

PARK6 is a common cause of familial parkinsonism

EM Valente et al.

NEUROLOGICAL SCIENCES (2002)

Article Neurosciences

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

R Betarbet et al.

NATURE NEUROSCIENCE (2000)