期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/ijms23073877
关键词
brain organoids; physiological electric field; neurogenesis; neuronal differentiation; neural network
资金
- National Science Foundation of China [31371004, 31570999]
- Jilin Provincial Department of Science and Technology: Key Scientific and Technological Research and Development Projects [20180201026YY]
- Jilin University: Norman Bethune Health Science Planned Research projects [2018B13]
Brain organoids can reproduce the regional three-dimensional tissue structure of human brains and the electric field plays an important role in promoting neural differentiation and tissue formation, making it a promising direction in neural tissue engineering.
Brain organoids can reproduce the regional three-dimensional (3D) tissue structure of human brains, following the in vivo developmental trajectory at the cellular level; therefore, they are considered to present one of the best brain simulation model systems. By briefly summarizing the latest research concerning brain organoid construction methods, the basic principles, and challenges, this review intends to identify the potential role of the physiological electric field (EF) in the construction of brain organoids because of its important regulatory function in neurogenesis. EFs could initiate neural tissue formation, inducing the neuronal differentiation of NSCs, both of which capabilities make it an important element of the in vitro construction of brain organoids. More importantly, by adjusting the stimulation protocol and special/temporal distributions of EFs, neural organoids might be created following a predesigned 3D framework, particularly a specific neural network, because this promotes the orderly growth of neural processes, coordinate neuronal migration and maturation, and stimulate synapse and myelin sheath formation. Thus, the application of EF for constructing brain organoids in a3D matrix could be a promising future direction in neural tissue engineering.
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