期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms23063230
关键词
sorted-graphene quantum dot; excitation-wavelength-independent photoluminescence; two-photon photoinactivation; near-infrared-II two-photon bioimaging; multi-drug resistant microbe
资金
- Nanjing University of Information Science and Technology, China [2018r047]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, China [CMEMR2021-B11]
- An Nan Hospital, China Medical University, Taiwan [ANHRF110-34]
- Allergy Immunology and Microbiome Center, China Medical University Children's Hospital, China Medical University, Taiwan [1JA8]
- E-Da Hospital, Taiwan
- Ministry of Science and Technology, Taiwan [MOST 110-2221-E-006-013-MY3]
- Academia Sinica Healthy Longevity Grand Challenge Competition, Taiwan [AS-HLGC-110-07]
Nitrogen doping and amino group functionalization improve the electron donation of graphene quantum dot-based materials, leading to enhanced two-photon absorption and luminescence. The sorted amino-N-GQDs show potential for applications in two-photon imaging and photodynamic therapy.
Nitrogen doping and amino group functionalization through chemical modification lead to strong electron donation. Applying these processes to a large pi-conjugated system of graphene quantum dot (GQD)-based materials as electron donors increases the charge transfer efficiency of nitrogen-doped amino acid-functionalized GQDs (amino-N-GQDs), resulting in enhanced two-photon absorption, post-two-photon excitation (TPE) stability, TPE cross-sections, and two-photon luminescence through the radiative pathway when the lifetime decreases and the quantum yield increases. Additionally, it leads to the generation of reactive oxygen species through two-photon photodynamic therapy (PDT). The sorted amino-N-GQDs prepared in this study exhibited excitation-wavelength-independent two-photon luminescence in the near-infrared region through TPE in the near-infrared-II region. The increase in size resulted in size-dependent photochemical and electrochemical efficacy, increased photoluminescence quantum yield, and efficient two-photon PDT. Therefore, the sorted amino-N-GQDs can be applicable as two-photon contrast probes to track and localize analytes in in-depth two-photon imaging executed in a biological environment along with two-photon PDT to eliminate infectious or multidrug-resistant microbes.
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