期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/ijms23073736
关键词
Pif1 helicase; DNA helicase; replication fork; replication fork barriers; G-quadruplexes; telomerase
资金
- NIH [P20GM121293]
- Winthrop P. Rockefeller Cancer Institute
Pif1 helicases are a multifunctional family of DNA helicases that play important roles in various cellular functions, including handling multiple barriers at the replication fork and regulating replication termination, fragment maturation, and break-induced replication.
Pif1 helicases are a multifunctional family of DNA helicases that are important for many aspects of genomic stability in the nucleus and mitochondria. Pif1 helicases are conserved from bacteria to humans. Pif1 helicases play multiple roles at the replication fork, including promoting replication through many barriers such as G-quadruplex DNA, the rDNA replication fork barrier, tRNA genes, and R-loops. Pif1 helicases also regulate telomerase and promote replication termination, Okazaki fragment maturation, and break-induced replication. This review highlights many of the roles and regulations of Pif1 at the replication fork that promote cellular health and viability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据