期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms23116268
关键词
ionizing radiation; ion beam therapy; UNIVERSE; dose rate; DNA repair; modeling; RBE; rat spinal cord
资金
- National Center for Tumor Diseases (NCT) [3.0-2015.22 BioDose]
- German Cancer Aid [111434, 70112975]
Accurate knowledge of relative biological effectiveness (RBE) and its dependencies is crucial for supporting ion beam therapy. However, the influence of different dose rates of reference radiation and ion beam is rarely considered. This study investigates the impact of dose-rate effects on predicted RBE by extending the ion beam RBE-model to include DNA damage repair kinetics. The study finds that dose-rate effects increase with dose and biological effects saturate at high dose rates.
Accurate knowledge of the relative biological effectiveness (RBE) and its dependencies is crucial to support modern ion beam therapy and its further development. However, the influence of different dose rates of the reference radiation and ion beam are rarely considered. The ion beam RBE-model within our UNIfied and VERSatile bio response Engine (UNIVERSE) is extended by including DNA damage repair kinetics to investigate the impact of dose-rate effects on the predicted RBE. It was found that dose-rate effects increase with dose and biological effects saturate at high dose-rates, which is consistent with data- and model-based studies in the literature. In a comparison with RBE measurements from a high dose in-vivo study, the predictions of the presented modification were found to be improved in comparison to the previous version of UNIVERSE and existing clinical approaches that disregard dose-rate effects. Consequently, DNA repair kinetics and the different dose rates applied by the reference and ion beams might need to be considered in biophysical models to accurately predict the RBE. Additionally, this study marks an important step in the further development of UNIVERSE, extending its capabilities in giving theoretical guidance to support progress in ion beam therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据