期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms23105502
关键词
neuroinflammation; diabetes; pioglitazone; anti-inflammatory effect; exploratory behaviors; memory
资金
- Funds for Statutory Activity of Medical University of Lublin, Poland [DS38/2019]
Untreated diabetes can lead to the development of neuroinflammation and cognitive impairment. The study investigated the anti-inflammatory potential of pioglitazone in a mouse model of neuroinflammation related to diabetes and found that pioglitazone reduced inflammatory markers and improved memory and exploratory activity.
Many relevant studies, as well as clinical practice, confirm that untreated diabetes predisposes the development of neuroinflammation and cognitive impairment. Having regard for the fact that PPAR gamma are widely distributed in the brain and PPAR gamma ligands may regulate the inflammatory process, the anti-inflammatory potential of the PPAR gamma agonist, pioglitazone, was assessed in a mouse model of neuroinflammation related with diabetes. In this regard, the biochemical and molecular indicators of neuroinflammation were determined in the hippocampus and prefrontal cortex of diabetes mice. The levels of cytokines (IL-1 beta, IL-6, and TNF) and the expression of genes (Tnfrsf1a and Cav1) were measured. In addition, behavioral tests such as the open field test, the hole-board test, and the novel object recognition test were conducted. A 14-day treatment with pioglitazone significantly decreased IL-6 and TNF alpha levels in the prefrontal cortex and led to the downregulation of Tnfrsf1a expression and the upregulation of Cav1 expression in both brain regions of diabetic mice. Pioglitazone, by targeting neuroinflammatory signaling, improved memory and exploratory activity in behavioral tests. The present study provided a potential theoretical basis and therapeutic target for the treatment of neuroinflammation associated with diabetes. Pioglitazone may provide a promising therapeutic strategy in diabetes patients with muffled of behavioral activity.
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