期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms23063139
关键词
convection-enhanced delivery; brain; infusion; fluid flow; mass transport; tissue deformation; molecular interactions
资金
- EDEN 2020 - European Union's H2020 Research and Innovation Programme [688279]
- Engineering and Physical Sciences Research Council (EPSRC) [EP/N025954/1]
This article focuses on the application of infusion-based targeted drug delivery in the treatment of brain diseases such as glioblastoma multiforme. The author emphasizes the biomechanical and biochemical aspects of drug delivery and discusses the challenges and advances in medical robotics in targeted drug delivery in the brain. Additionally, the critical overview of current research and its clinical implications is provided.
Targeted drug delivery in the brain is instrumental in the treatment of lethal brain diseases, such as glioblastoma multiforme, the most aggressive primary central nervous system tumour in adults. Infusion-based drug delivery techniques, which directly administer to the tissue for local treatment, as in convection-enhanced delivery (CED), provide an important opportunity; however, poor understanding of the pressure-driven drug transport mechanisms in the brain has hindered its ultimate success in clinical applications. In this review, we focus on the biomechanical and biochemical aspects of infusion-based targeted drug delivery in the brain and look into the underlying molecular level mechanisms. We discuss recent advances and challenges in the complementary field of medical robotics and its use in targeted drug delivery in the brain. A critical overview of current research in these areas and their clinical implications is provided. This review delivers new ideas and perspectives for further studies of targeted drug delivery in the brain.
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