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CANCER RESEARCH (2020)
RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
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FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy
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CELLS (2020)
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CANCERS (2020)
FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair
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CIRCULATION (2019)
The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA
Jie Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression updates through inhibiting BNIP3
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Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia
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CANCER CELL (2019)
Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation
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NUCLEIC ACIDS RESEARCH (2019)
Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1
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SCIENCE TRANSLATIONAL MEDICINE (2019)
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
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NATURE COMMUNICATIONS (2019)
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells
Dongling Zou et al.
CANCER CELL INTERNATIONAL (2019)
The role of the fat mass and obesity-associated protein in the proliferation of pancreatic cancer cells
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ONCOLOGY LETTERS (2019)
m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
Establishing a genetic link between FTO and VDR gene polymorphisms and obesity in the Emirati population
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BMC MEDICAL GENETICS (2018)
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
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CELL (2018)
Analysis of the Impact of Common Polymorphisms of the FTO and MC4R Genes with the Risk of Severe Obesity in Saudi Arabian Population
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GENETIC TESTING AND MOLECULAR BIOMARKERS (2018)
Multiple genetic variations confer risks for obesity and type 2 diabetes mellitus in arab descendants from UAE
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INTERNATIONAL JOURNAL OF OBESITY (2018)
Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?
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MEDICAL PRINCIPLES AND PRACTICE (2018)
FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting -catenin through mRNA demethylation
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MOLECULAR CARCINOGENESIS (2018)
Recognition of RNA N6- methyladenosine by IGF2BP proteins enhances mRNA stability and translation
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NATURE CELL BIOLOGY (2018)
FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2018)
A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome
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CELL REPORTS (2018)
Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta-analysis
Xiaoyi Huang et al.
EUROPEAN JOURNAL OF CANCER CARE (2017)
Reversible methylation of m6Am in the 5′ cap controls mRNA stability
Jan Mauer et al.
NATURE (2017)
The Emerging Role of Zfp217 in Adipogenesis
Hong Xiang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing
Marek Bartosovic et al.
NUCLEIC ACIDS RESEARCH (2017)
FTO expression is associated with the occurrence of gastric cancer and prognosis
Dong Xu et al.
ONCOLOGY REPORTS (2017)
The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway
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ONCOLOGY LETTERS (2017)
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
Qi Cui et al.
CELL REPORTS (2017)
AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine
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SCIENTIFIC REPORTS (2017)
Cytoplasmic m6A reader YTHDF3 promotes mRNA translation
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CELL RESEARCH (2017)
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase
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CANCER CELL (2017)
Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay
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JOURNAL OF MEDICAL GENETICS (2016)
Estrogen promotes fat mass and obesity-associated protein nuclear localization and enhances endometrial cancer cell proliferation via the mTOR signaling pathway
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ONCOLOGY REPORTS (2016)
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
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SCIENCE TRANSLATIONAL MEDICINE (2016)
Fto-Deficiency Affects the Gene and MicroRNA Expression Involved in Brown Adipogenesis and Browning of White Adipose Tissue in Mice
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Cell Models and Their Application for Studying Adipogenic Differentiation in Relation to Obesity: A Review
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
mRNA m6A methylation downregulates adipogenesis in porcine adipocytes
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Myc and cell cycle control
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BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
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CELL (2015)
Decreased N-6-Methyladenosine in Peripheral Blood RNA From Diabetic Patients Is Associated With FTO Expression Rather Than ALKBH5
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Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)
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JOURNAL OF MEDICINAL CHEMISTRY (2015)
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
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NEW ENGLAND JOURNAL OF MEDICINE (2015)
FTO influences adipogenesis by regulating mitotic clonal expansion
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NATURE COMMUNICATIONS (2015)
Meclofenamic acid selectively inhibits FTO demethylation of m(6)A over ALKBH5
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NUCLEIC ACIDS RESEARCH (2015)
The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation
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PLOS ONE (2015)
Synthesis of a FTO Inhibitor with Anticonvulsant Activity
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ACS CHEMICAL NEUROSCIENCE (2014)
Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice
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CELL METABOLISM (2014)
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
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CELL RESEARCH (2014)
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CELL RESEARCH (2014)
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N6-methyladenosine-dependent regulation of messenger RNA stability
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NATURE (2014)
Obesity-associated variants within FTO form long-range functional connections with IRX3
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CANCER DISCOVERY (2014)
Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case-control study in Japan
Yingsong Lin et al.
BMC CANCER (2013)
FTO Deficiency Induces UCP-1 Expression and Mitochondrial Uncoupling in Adipocytes
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ENDOCRINOLOGY (2013)
A link between FTO, ghrelin, and impaired brain food-cue responsivity
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JOURNAL OF CLINICAL INVESTIGATION (2013)
The role of interleukin 1β in the anti-adipogenic action of macrophages on human preadipocytes
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JOURNAL OF ENDOCRINOLOGY (2013)
Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)
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JOURNAL OF MEDICINAL CHEMISTRY (2013)
Genome-wide association studies identify four ER negative-specific breast cancer risk loci
Montserrat Garcia-Closas et al.
NATURE GENETICS (2013)
A variant in FTO shows association with melanoma risk not due to BMI
Mark M. Iles et al.
NATURE GENETICS (2013)
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
Keri L. Monda et al.
NATURE GENETICS (2013)
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
Martin E. Hess et al.
NATURE NEUROSCIENCE (2013)
Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse
Fiona McMurray et al.
PLOS GENETICS (2013)
Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma
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CANCER (2012)
Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways
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CANCER LETTERS (2012)
mTOR Signaling in Growth Control and Disease
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CELL (2012)
Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer
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CELL METABOLISM (2012)
Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
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NATURE (2012)
Meta-analysis identifies common variants associated with body mass index in east Asians
Wanqing Wen et al.
NATURE GENETICS (2012)
Associations of Variants in FTO and Near MC4R With Obesity Traits in South Asian Indians
Senthil K. Vasan et al.
OBESITY (2012)
Association of Obesity-related Genetic Variants With Endometrial Cancer Risk: A Report From the Shanghai Endometrial Cancer Genetics Study
Ryan J. Delahanty et al.
AMERICAN JOURNAL OF EPIDEMIOLOGY (2011)
The role of the fat mass and obesity associated gene (FTO) in breast cancer risk
Virginia Kaklamani et al.
BMC MEDICAL GENETICS (2011)
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
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CANCER CELL (2011)
Body Mass Index and Obesity- and Diabetes-Associated Genotypes and Risk for Pancreatic Cancer
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CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2011)
Cross-Talk Between Interferon-γ and Hedgehog Signaling Regulates Adipogenesis
Jelena Todoric et al.
DIABETES (2011)
An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference
S. D. Rees et al.
DIABETIC MEDICINE (2011)
Genome-wide linkage and peak-wide association study of obesity-related quantitative traits in Caribbean Hispanics
Chuanhui Dong et al.
HUMAN GENETICS (2011)
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Guifang Jia et al.
NATURE CHEMICAL BIOLOGY (2011)
The Obesity-Associated Polymorphisms FTO rs9939609 and MC4R rs17782313 and Endometrial Cancer Risk in Non-Hispanic White Women
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Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
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CANCER CELL (2010)
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EMBO MOLECULAR MEDICINE (2010)
The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels
Tea Berulava et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2010)
Crystal structure of the FTO protein reveals basis for its substrate specificity
Zhifu Han et al.
NATURE (2010)
Overexpression of Fto leads to increased food intake and results in obesity
Chris Church et al.
NATURE GENETICS (2010)
The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice
Xue Gao et al.
PLOS ONE (2010)
Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations
Sarah Boissel et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2009)
Association Analysis of Variation in/Near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B With Type 2 Diabetes and Related Quantitative Traits in Pima Indians
Rong Rong et al.
DIABETES (2009)
Variation in the FTO Gene Influences Food Intake but not Energy Expenditure
A. Haupt et al.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2009)
The FTO gene and measured food intake in children
J. Wardle et al.
INTERNATIONAL JOURNAL OF OBESITY (2009)
Inactivation of the Fto gene protects from obesity
Julia Fischer et al.
NATURE (2009)
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
Yoon Shin Cho et al.
NATURE GENETICS (2009)
A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
Chris Church et al.
PLOS GENETICS (2009)
Obesity associated genetic variation in FTO is associated with diminished satiety
Jane Wardle et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)
Variations in the FTO gene are associated with severe obesity in the Japanese
Kikuko Hotta et al.
JOURNAL OF HUMAN GENETICS (2008)
An Obesity-Associated FTO Gene Variant and Increased Energy Intake in Children
Joanne E. Cecil et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
John R. Speakman et al.
OBESITY (2008)
The FTO gene is associated with adulthood obesity in the Mexican population
Marisela Villalobos-Comparan et al.
OBESITY (2008)
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
Thomas Gerken et al.
SCIENCE (2007)
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
Angelo Scuteri et al.
PLOS GENETICS (2007)
Amplification of zinc finger gene 217 (ZNF217) and cancer:: When good fingers go bad
Kate G. R. Quinlan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2007)
Variation in FTO contributes to childhood obesity and severe adult obesity
Christian Dina et al.
NATURE GENETICS (2007)
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Timothy M. Frayling et al.
SCIENCE (2007)
The candidate oncogene ZNF217 is frequently amplified in colon cancer
PH Rooney et al.
JOURNAL OF PATHOLOGY (2004)
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
J Luo et al.
CANCER CELL (2003)
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
I Vivanco et al.
NATURE REVIEWS CANCER (2002)
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