期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms23052776
关键词
Euglena gracilis; phototaxis; gravitaxis; photoactivated adenylyl cyclase; protein kinase A; RNA interference; indirect immuno-fluorescent assay; movement analysis
资金
- German Space Agency (DLR, Deutsches Zentrum fuer Luft- und Raumfahrt)
- BMWi [50WB1923]
Euglena gracilis uses light and gravity as environmental cues to regulate its position in water, but the molecular mechanism is largely unknown. This study reports the localization of the photoreceptor photoactivated adenylyl cyclase and its relationship with kinase A.
Euglena gracilis is a photosynthetic flagellate. To acquire a suitable position in its surrounding aquatic environment, it exploits light and gravity primarily as environmental cues. Several physiological studies have indicated a fine-tuned relationship between gravity sensing (gravitaxis) and light sensing in E. gracilis. However, the underlying molecular mechanism is largely unknown. The photoreceptor photoactivated adenylyl cyclase (PAC) has been studied for over a decade. Nevertheless, no direct/indirect interaction partner (upstream/downstream) has been reported for PAC. It has been shown that a specific protein, kinase A (PKA), showed to be involved in phototaxis and gravitaxis. The current study reports the localization of the specific PKA and its relationship with PAC.
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