期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms23116031
关键词
lignan; antioxidant; oxidative stress; anti-inflammatory; inflammation; chemical synthesis
资金
- Russian Science Foundation [21-15-00322]
- Russian Science Foundation [21-15-00322] Funding Source: Russian Science Foundation
This review provides an up-to-date overview of the current research progress on the mechanisms of action, pharmacological effects, and chemical synthesis methods of lignans in diseases associated with oxidative stress and inflammation.
Plant lignans exhibit a wide range of biological activities, which makes them the research objects of potential use as therapeutic agents. They provide diverse naturally-occurring pharmacophores and are available for production by chemical synthesis. A large amount of accumulated data indicates that lignans of different structural groups are apt to demonstrate both anti-inflammatory and antioxidant effects, in many cases, simultaneously. In this review, we summarize the comprehensive knowledge about lignan use as a bioactive agent in disorders associated with oxidative stress and inflammation, pharmacological effects in vitro and in vivo, molecular mechanisms underlying these effects, and chemical synthesis approaches. This article provides an up-to-date overview of the current data in this area, available in PubMed, Scopus, and Web of Science databases, screened from 2000 to 2022.
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