期刊
CANCER BIOLOGY & THERAPY
卷 16, 期 6, 页码 898-911出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384047.2015.1028702
关键词
ELMO1; glioma; invasion; IL-8
类别
资金
- National Natural Scientific Foundation of China [81072068, 81472365]
- Scientific Foundation of Shandong Province [ZR2014HM003, ZR2014HM086, ZR2011HL047]
- The Young and Middle-Aged Scientists Research Awards Foundation of Shandong Province [2010BSB14050, BS2013YY020]
- Foundation of Shandong Educational Committee [J14LK13]
- Shandong medical and health science and technology development plan [2013WS0282]
- Foundation of Weifang Scientific Committee [20121230]
Glioma is the most common form of primary malignant brain cancers. Tumor cell invasiveness is a critical challenge in the clinical management of glioma patients. The invasive biological feature of glioma cell is stimulated by both autocrine and paracrine factors including chemokine IL-8. In this study, we report that the production of IL-8 is higher in glioma tissues and cells than adjacent nontumor tissues (ANT) and normal glial cells. Autocrine IL-8 can increase the invasive ability of glioma cells by binding to CXCR1. In addition, high expression of IL-8 indicates poor prognosis of glioma patients. Furthermore, IL-8 is capable of modulating cell migration and invasion by regulating the activation of RAC1 which resulted in cytoskeletal reorganisation in an ELMO1 dependent manner. Finally, we found that IL-8 could enhance mesenchymal transition(MT) of glioma cells by activating ELMO1-NF-B-Snail signaling. Our data indicate that IL-8 autocrine is responsible for the invasive phenotype of glioma and IL-8 may be a useful prognostic marker for glioma and novel therapeutic target for glioma invasion intervention.
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