期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 64, 期 4, 页码 840-851出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b05691
关键词
bioactive plant; polyphenol; tannin; hydrolyzable tannin; nematode; Haemonchus contortus; natural anthelmintic; SEM
资金
- University of Turku
- European Commission [PITN-GA-2011-289377]
- Academy of Finland [258992, 251388]
- Svenska tekniska vetenskapsakademien i Finland (STV)
- Strategic Research Grant (Ecological Interactions)
- Academy of Finland (AKA) [251388, 251388] Funding Source: Academy of Finland (AKA)
The use of synthetic drugs against gastrointestinal nematodes of ruminants has led to a situation where resistance to anthelmintics is widespread, and there is an urgent need for alternative solutions for parasite control. One promising approach is to use polyphenol-rich bioactive plants in animal feeds as natural anthelmintics. In the present work, the in vitro activity of a series of 33 hydrolyzable tannins (HTs) and their hydrolysis product, gallic acid, against egg hatching and motility of L1 and L2 stage Haemonchus contortus larvae was studied. The effect of the selected compounds on egg and larval structure was further studied by scanning electron microscopy. The results indicated clear relationships between HT structure and anthelmintic activity. While HT size, overall flexibility, the types and numbers of functional groups, together with the linkage types between monomeric HTs affected the activity differently, the optimal structure was found with pentagalloylglucose.
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