期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 64, 期 48, 页码 9143-9151出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b04020
关键词
topsentin alkaloids; natural product; anti-TMV activity; antifungal activity; agrochemical
资金
- National Natural Science Foundation of China [21132003, 21421062, 21372131, 21402142, 21302038, 21672117]
- Tianjin Natural Science Foundation [16JCZDJC32400, 15JCQNJC05600]
- Scientific Research Foundation of Tianjin Normal University [5KQM110021]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130031110017]
Topsentin alkaloids and their derivatives were designed, synthesized, and characterized on the basis of NMR and mass spectroscopy. The antiviral activities against tobacco mosaic virus (TMV) and anti-phytopathogenic fungus activities of these alkaloids were evaluated for the first time. Alkaloids 1c, 1e, 2b, and 2d displayed significantly higher antiviral activities against TMV than Ribavirin, emerging as new lead compounds for anti-TMV research. Further fungicidal activity tests against 14 kinds of phytopathogenic fungi revealed that these alkaloids displayed broad-spectrum fungicidal activities. Topsentin derivative 2d with 4-5 mg/kg EC50 values against Sclerotinia sclerotiorum (Lib.), Rhizoctonia solani (Kuhn), and Botrytis cinerea (Pers.) emerged as a new lead compound for fungicidal research. Current studies provide support for the application of topsentin alkaloids as novel agrochemicals.
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