期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 116, 期 -, 页码 91-100出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2021.12.326
关键词
SARS-CoV-2; SARS-CoV-2 variants; COVID-19; Mortality; Hospitalization; High-throughput nucleotide sequencing
资金
- Colombian Ministry of Science, Technology and Innovation [366-2020]
This study explored the relationship between the molecular characterization of SARS-CoV-2 and disease severity in Colombia. The results indicate that infection with the B.1.621 variant is associated with increased hospitalization and mortality rates.
Objectives: This study aimed to explore associations between the molecular characterization of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and disease severity in ambulatory and hospitalized patients in two main Colombian epicentres during the first year of the coronavirus disease 2019 pandemic. Methods: In total, 10 0 0 patients with SARS-CoV-2 infection were included in this study. Clinical data were collected from 997 patients, and 678 whole-genome sequences were obtained by massively parallel sequencing. Bivariate, multi-variate, and classification and regression tree analyses were run between clinical and genomic variables. Results: Age > 88 years, and infection with lineages B.1.1, B.1.1.388, B.1.523 or B.1.621 for patients aged 71- 88 years were associated with death [odds ratio (OR) 6.048036, 95% confidence interval (CI) 1.346567- 32.92521; P = 0.01718674]. The need for hospitalization was associated with higher age and comorbidities. The hospitalization rate increased significantly for patients aged 38-51 years infected with lineages A, B, B.1.1.388, B.1.1.434, B.1.153, B.1.36.10, B.1.411, B.1.471, B.1.558 or B.1.621 (OR 8.368427, 95% CI 2.573145-39.10672, P = 0.0 0 012). Associations between clades and clinical outcomes diverged from previously reported data. Conclusions: Infection with lineage B.1.621 increased the hospitalization and mortality rates. These findings, plus the rapidly increasing prevalence in Colombia and other countries, suggest that lineage B.1.621 should be considered as a 'variant of interest'. If associated disease severity is confirmed, possible designation as a 'variant of concern' should be considered. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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