Sentinel lymph node mapping versus sentinel lymph node mapping with systematic lymphadenectomy in endometrial cancer: an open-label, non-inferiority, randomized trial (ALICE trial)

Article Oncology

A phase III randomized clinical trial comparing sentinel node biopsy with no retroperitoneal node dissection in apparent early-stage endometrial cancer - ENDO-3: ANZGOG trial 1911/2020

Andreas Obermair et al.

Summary: The ENDO-3 trial aims to evaluate the value of sentinel node biopsy in the surgical management of endometrial cancer, comparing its effectiveness and potential harms with no retroperitoneal node dissection. The trial design is a phase III, open-label, two-arm, multistage, randomized non-inferiority trial with the primary endpoint being surgical recovery and disease-free survival at 4.5 years.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2021)

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Article Oncology

Development of a surgical competency assessment tool for sentinel lymph node dissection by minimally invasive surgery for endometrial cancer

Kristen Moloney et al.

Summary: Specific mandatory and prohibited steps of sentinel lymph node dissection in endometrial cancer have been identified and validated based on consensus among a large number of international experts. A competency assessment tool is now available and can be used for surgeon selection in clinical trials and for ongoing, prospective quality assurance in routine clinical care. The tool demonstrated high internal consistency and was effective in differentiating between skill levels in surgical videos.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2021)

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Article Surgery

Assessment of Sentinel Lymph Node Biopsy vs Lymphadenectomy for Intermediate- and High-Grade Endometrial Cancer Staging

Maria C. Cusimano et al.

Summary: In women with intermediate- and high-grade endometrial cancer, sentinel lymph node biopsy (SLNB) showed a sensitivity of 96% and a negative predictive value of 99% for nodal metastasis detection. SLNB had acceptable diagnostic accuracy and improved the detection of node-positive cases compared with lymphadenectomy, suggesting it is a viable option for surgical staging in this patient population.

JAMA SURGERY (2021)

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Article Oncology

Sentinel lymph Node mapping versus systematic pelvic lymphadenectomy on the prognosis for patients with intermediate-high-risk Endometrial Cancer confined to the uterus before surgery: trial protocol for a non-inferiority randomized controlled trial (SNEC trial)

Jun Guan et al.

Summary: This study aims to investigate whether SLN mapping is non-inferior to pelvic lymphadenectomy in terms of prognosis for intermediate-high-risk EC patients confined to uterus. A total of 780 patients will be randomly recruited and followed up for 5 years, focusing on 2-year and 5-year progression-free survival, overall survival, surgery-related adverse events, and quality of life.

JOURNAL OF GYNECOLOGIC ONCOLOGY (2021)

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Article Oncology