期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 37, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/gps.5703
关键词
autonomic symptoms; dementia with Lewy bodies; mild cognitive impairment
资金
- GE Healthcare
- Alzheimer's Research UK
- NIHR Newcastle Biomedical Research Centre
This study aimed to compare the autonomic symptoms between the cognitive prodrome of Lewy body dementia (MCI-LB) and healthy older adults, as well as mild cognitive impairment due to Alzheimer's disease (MCI-AD). The study found that MCI-LB had more severe autonomic symptoms compared to normal aging and MCI-AD, but the autonomic symptoms were not specific to MCI-LB. The COMPASS-31 scale may have value as a sensitive screening test for early-stage Lewy body disease.
Objectives: Autonomic symptoms are a common feature of the synucleinopathies, and may be a distinguishing feature of prodromal Lewy body disease. We aimed to assess whether the cognitive prodrome of dementia with Lewy bodies, mild cognitive impairment (MCI) with Lewy bodies (MCI-LB), would have more severe reported autonomic symptoms than cognitively healthy older adults, with MCI due to Alzheimer's disease (MCI-AD) also included for comparison. We also aimed to assess the utility of an autonomic symptom scale in differentiating MCI-LB from MCI-AD. Methods: Ninety-three individuals with MCI and 33 healthy controls were assessed with the Composite Autonomic Symptom Score 31-item scale (COMPASS). Mild cognitive impairment patients also underwent detailed clinical assessment and differential classification of MCI-AD or MCI-LB according to current consensus criteria. Differences in overall COMPASS score and individual symptom sub-scales were assessed, controlling for age. Results: Age-adjusted severity of overall autonomic symptomatology was greater in MCI-LB (Ratio = 2.01, 95% CI: 1.37-2.96), with higher orthostatic intolerance and urinary symptom severity than controls, and greater risk of gastrointestinal and secretomotor symptoms. MCI-AD did not have significantly higher autonomic symptom severity than controls overall. A cut-off of 4/5 on the COMPASS was sensitive to MCI-LB (92%) but not specific to this (42% specificity vs. MCI-AD and 52% vs. healthy controls). Conclusions: Mild cognitive impairment with Lewy bodies had greater autonomic symptom severity than normal ageing and MCI-AD, but such autonomic symptoms are not a specific finding. The COMPASS-31 may therefore have value as a sensitive screening test for early-stage Lewy body disease.
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