期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 64, 期 24, 页码 4908-4913出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b01237
关键词
A beta; ADAM10; brain; SAMP8; sesaminol
资金
- Ministry of Agriculture, Forestry, and Fisheries of Japan
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [15K07426]
- Grants-in-Aid for Scientific Research [16H03288, 15K07426, 26450153] Funding Source: KAKEN
Alzheimer's disease (AD) is characterized by the progressive accumulation of extracellular beta-amyloid (A beta) aggregates. Recently, the senescence-accelerated mouse-prone 8 (SAMP8) model was highlighted as a useful model of age-related AD. Therefore, we used the SAMP8 mouse to investigate the preventive effects of sesame lignans on the onset of AD-like pathology. In preliminary in vitro studies, sesaminol showed the greatest inhibitory effect on A beta oligomerization and fibril formation relative to sesamin, sesamolin, and sesaminol triglucoside. Hence, sesaminol was selected for further evaluation in vivo. In SAMP8 mice, feed-through sesaminol (0.05%, w/w, in standard chow) administered over a 16 week period reduced brain A beta accumulation and decreased serum 8-hydroxydeoxyguanosine, an indicator of oxidative stress. Furthermore, sesaminol administration increased the gene and protein expression of ADAM10, which is a protease centrally involved in the non-amyloidogenic processing of amyloid precursor protein. Taken together, these data suggest that long-term consumption of sesaminol may inhibit the accumulation of pathogenic A beta in the brain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据