相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Isocitrate Dehydrogenase Mutant Grade II and III Glial Neoplasms
Ingo K. Mellinghoff et al.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2022)
Phase I/II trial of vorinostat and radiation and maintenance vorinostat in children with diffuse intrinsic pontine glioma: A Children's Oncology Group report
Jack M. Su et al.
NEURO-ONCOLOGY (2022)
Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network
Xiaorong Gu et al.
LEUKEMIA (2021)
Reduced H3K27me3 levels in diffuse gliomas: association with 1p/19q codeletion and difference from H3K27me3 loss in malignant peripheral nerve sheath tumors
Keiichiro Kitahama et al.
BRAIN TUMOR PATHOLOGY (2021)
EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood
Michael Weller et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2021)
A pilot clinical trial of oral tetrahydrouridine/decitabine for noncytotoxic epigenetic therapy of chemoresistant lymphoid malignancies
Brian Hill et al.
SEMINARS IN HEMATOLOGY (2021)
Phase I Assessment of Safety and Therapeutic Activity of BAY1436032 in Patients with IDH1-Mutant Solid Tumors
Antje Wick et al.
CLINICAL CANCER RESEARCH (2021)
A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
Yiqun Zhang et al.
NATURE COMMUNICATIONS (2021)
Clinical Trials Assessing Hypomethylating Agents Combined with Other Therapies: Causes for Failure and Potential Solutions
Phaedon D. Zavras et al.
CLINICAL CANCER RESEARCH (2021)
Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial
Ingo K. Mellinghoff et al.
CLINICAL CANCER RESEARCH (2021)
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
David N. Louis et al.
NEURO-ONCOLOGY (2021)
Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture
Michael Lattke et al.
NATURE COMMUNICATIONS (2021)
PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation
Xiaorong Gu et al.
CELL REPORTS (2021)
Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches
Yorg Dillen et al.
TRANSLATIONAL STROKE RESEARCH (2020)
A Potent Blood-Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model
Yukino Machida et al.
MOLECULAR CANCER THERAPEUTICS (2020)
Coordination of germ layer lineage choice by TET1 during primed pluripotency
Xinlong Luo et al.
GENES & DEVELOPMENT (2020)
Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma
Zenon Konteatis et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
A phase Ib/II study of olutasidenib in patients with relapsed/refractory IDH1 mutant gliomas: Safety and efficacy as single agent and in combination with azacitidine.
Macarena Ines De La Fuente et al.
JOURNAL OF CLINICAL ONCOLOGY (2020)
Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model
Haley E. Ramsey et al.
TARGETED ONCOLOGY (2020)
MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence
Radhika Mathur et al.
NEURO-ONCOLOGY (2020)
A Bayesian adaptive randomized phase II multicenter trial of bevacizumab with or without vorinostat in adults with recurrent glioblastoma
Vinay K. Puduvalli et al.
NEURO-ONCOLOGY (2020)
A phase 2 study of valproic acid and radiation, followed by maintenance valproic acid and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma or high-grade glioma
Jack Meng-Fen Su et al.
PEDIATRIC BLOOD & CANCER (2020)
Ivosidenib in Isocitrate Dehydrogenase 1-Mutated Advanced Glioma
Ingo K. Mellinghoff et al.
JOURNAL OF CLINICAL ONCOLOGY (2020)
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
Charles P. Couturier et al.
NATURE COMMUNICATIONS (2020)
Histone H3.3G34-Mutant Intemeuron Progenitors Co-opt PDGFRA for Gliomagenesis
Carol C. L. Chen et al.
CELL (2020)
Exome sequencing identifies frequent genomic loss of TET1 in IDH-wild-type glioblastoma
Sebastian Stasik et al.
NEOPLASIA (2020)
H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation
Ashot S. Harutyunyan et al.
CELL REPORTS (2020)
Basic Gene Expression Characteristics of Glioma Stem Cells and Human Glioblastoma
Daisuke Sakamoto et al.
ANTICANCER RESEARCH (2019)
Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis
Verena Koerber et al.
CANCER CELL (2019)
The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1
Aixia Sui et al.
NEUROCHEMISTRY INTERNATIONAL (2019)
Phase I study of a brain penetrant mutant IDH1 inhibitor DS-1001b in patients with recurrent or progressive IDH1 mutant gliomas.
Atsushi Natsume et al.
JOURNAL OF CLINICAL ONCOLOGY (2019)
EZH2 Inhibitors: Take It EZy, It Is All About Context
Vamsidhar Velcheti et al.
CANCER DISCOVERY (2019)
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Cyril Neftel et al.
CELL (2019)
Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas
Philip Jonsson et al.
CLINICAL CANCER RESEARCH (2019)
The cancer driver genes IDH1/2, JARID1C/KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism
Soojeong Chang et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2019)
Glutamatergic synaptic input to glioma cells drives brain tumour progression
Varun Venkataramani et al.
NATURE (2019)
The diverse roles of DNA methylation in mammalian development and disease
Maxim V. C. Greenberg et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells
Xiuxing Wang et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG
Jamie N. Anastas et al.
CANCER CELL (2019)
Longitudinal molecular trajectories of diffuse glioma in adults
Floris P. Barthel et al.
NATURE (2019)
Self-organization of parS centromeres by the ParB CTP hydrolase
Young-Min Soh et al.
SCIENCE (2019)
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype
Giulia Stazi et al.
CLINICAL EPIGENETICS (2019)
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
Ashot S. Harutyunyan et al.
NATURE COMMUNICATIONS (2019)
Phase I/II trial of vorinostat, bevacizumab, and daily temozolomide for recurrent malignant gliomas
Katherine B. Peters et al.
JOURNAL OF NEURO-ONCOLOGY (2018)
Phase I/II trial of vorinostat combined with temozolomide and radiation therapy for newly diagnosed glioblastoma: results of Alliance N0874/ABTC 02
Evanthia Galanis et al.
NEURO-ONCOLOGY (2018)
Phase II Study of Bevacizumab and Vorinostat for Patients with Recurrent World Health Organization Grade 4 Malignant Glioma
Ashley Ghiaseddin et al.
ONCOLOGIST (2018)
Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns
Laura Magill Sack et al.
CELL (2018)
The Human Transcription Factors
Samuel A. Lambert et al.
CELL (2018)
Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation
Kirsten Obernier et al.
CELL STEM CELL (2018)
ATRX Promotes DNA Repair Synthesis and Sister Chromatid Exchange during Homologous Recombination
Szilvia Juhasz et al.
MOLECULAR CELL (2018)
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Mariella G. Filbin et al.
SCIENCE (2018)
Chromatin Regulation of Neuronal Maturation and Plasticity
David A. Gallegos et al.
TRENDS IN NEUROSCIENCES (2018)
Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
Carla Danussi et al.
NATURE COMMUNICATIONS (2018)
A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence
Camila Ferreira de Souza et al.
CELL REPORTS (2018)
Mutant IDH1 Promotes Glioma Formation In Vivo
Beatrice Philip et al.
CELL REPORTS (2018)
Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates
Xiaorong Gu et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Human glioblastoma arises from subventricular zone cells with low-level driver mutations
Joo Ho Lee et al.
NATURE (2018)
Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells
Francis O. Enane et al.
CELL DEATH & DISEASE (2018)
Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes
Neha Tiwari et al.
CELL STEM CELL (2018)
Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway
G. R. Sareddy et al.
ONCOGENE (2017)
Detailed longitudinal sampling of glioma stem cells in situ reveals Chr7 gain and Chr10 loss as repeated events in primary tumor formation and recurrence
Mehmet Baysan et al.
INTERNATIONAL JOURNAL OF CANCER (2017)
GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition
Francis O. Enane et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy
Xiaoyang Lan et al.
NATURE (2017)
Targeting glioma stem cells through combined BMI1 and EZH2 inhibition
Xun Jin et al.
NATURE MEDICINE (2017)
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas
Faizaan Mohammad et al.
NATURE MEDICINE (2017)
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Andrew S. Venteicher et al.
SCIENCE (2017)
Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2
Aram S. Modrek et al.
CELL REPORTS (2017)
The Role of ATRX in Glioma Biology
Pravanya Nandakumar et al.
FRONTIERS IN ONCOLOGY (2017)
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting
Bernd Schuettengruber et al.
CELL (2017)
Defining a Cancer Dependency Map
Aviad Tsherniak et al.
CELL (2017)
Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo
Stefan Pusch et al.
ACTA NEUROPATHOLOGICA (2017)
Writing, erasing and reading histone lysine methylations
Kwangbeom Hyun et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2017)
Transcriptional Addiction in Cancer
James E. Bradner et al.
CELL (2017)
Insulator dysfunction and oncogene activation in IDH mutant gliomas
William A. Flavahan et al.
NATURE (2016)
Integrated genomic characterization of IDH1-mutant glioma malignant progression
Hanwen Bai et al.
NATURE GENETICS (2016)
Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis
Chiara Bardella et al.
CANCER CELL (2016)
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
Michele Ceccarelli et al.
CELL (2016)
No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3
M. Wiese et al.
KLINISCHE PADIATRIE (2016)
New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
Hsiao P. J. Voon et al.
NUCLEIC ACIDS RESEARCH (2016)
Neurogenesis in the Developing and Adult Brain-Similarities and Key Differences
Magdalena Goetz et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)
Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment
Hinke F. van Thuijl et al.
ACTA NEUROPATHOLOGICA (2015)
DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors
Tali Mazor et al.
CANCER CELL (2015)
Activating transcription factor 3 is overexpressed in human glioma and its knockdown in glioblastoma cells causes growth inhibition both in vitro and in vivo
Siqi Ma et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)
A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma
Andra V. Krauze et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2015)
CDKN2A Loss Is Associated With Shortened Overall Survival in Lower-Grade (World Health Organization Grades II-III) Astrocytomas
Gerald F. Reis et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2015)
Mutational landscape and clonal architecture in grade II and III gliomas
Hiromichi Suzuki et al.
NATURE GENETICS (2015)
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
Catherine S. Grasso et al.
NATURE MEDICINE (2015)
Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia
Britta Will et al.
NATURE MEDICINE (2015)
Phase II study of panobinostat in combination with bevacizumab for recurrent glioblastoma and anaplastic glioma
Eudocia Q. Lee et al.
NEURO-ONCOLOGY (2015)
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
Daniel J. Brat et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
Neurogenesis in the Adult Hippocampus
Gerd Kempermann et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
DNA copy number analysis of Grade II-III and Grade IV gliomas reveals differences in molecular ontogeny including chromothripsis associated with IDH mutation status
Adam Cohen et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming
Radhika Arasala Rao et al.
SCIENTIFIC REPORTS (2015)
Most Human Non-GCIMP Glioblastoma Subtypes Evolve from a Common Proneural-like Precursor Glioma
Tatsuya Ozawa et al.
CANCER CELL (2014)
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Mario L. Suva et al.
CELL (2014)
Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin
Katherine A. Hoadley et al.
CELL (2014)
Runx1 Regulation of Pu.1 Corepressor/Coactivator Exchange Identifies Specific Molecular Targets for Leukemia Differentiation Therapy
Xiaorong Gu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The role of glutamate and its receptors in the proliferation, migration, differentiation and survival of neural progenitor cells
Linda C. Jansson et al.
JOURNAL OF NEURAL TRANSMISSION (2014)
A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1
Jun Sung Lee et al.
NEURO-ONCOLOGY (2014)
Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma
Brett E. Johnson et al.
SCIENCE (2014)
Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe
M. Cornago et al.
CELL DEATH & DISEASE (2014)
Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge
Dominik Sturm et al.
NATURE REVIEWS CANCER (2014)
TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator
Ya-Ping Tsai et al.
GENOME BIOLOGY (2014)
The Somatic Genomic Landscape of Glioblastoma
Cameron W. Brennan et al.
CELL (2013)
The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation
Anke Sparmann et al.
EMBO JOURNAL (2013)
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS
Rachel Deplus et al.
EMBO JOURNAL (2013)
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
Kui-Ming Chan et al.
GENES & DEVELOPMENT (2013)
Transcriptional regulation by Polycomb group proteins
Luciano Di Croce et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
Dan Rohle et al.
SCIENCE (2013)
5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft
Alexandra Borodovsky et al.
ONCOTARGET (2013)
Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.
Sevin Turcan et al.
ONCOTARGET (2013)
Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation
K. P. Ng et al.
ONCOGENESIS (2013)
Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma
Dominik Sturm et al.
CANCER CELL (2012)
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lu et al.
NATURE (2012)
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Sevin Turcan et al.
NATURE (2012)
Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study
Bret B. Friday et al.
NEURO-ONCOLOGY (2012)
Sox9 and NFIA Coordinate a Transcriptional Regulatory Cascade during the Initiation of Gliogenesis
Peng Kang et al.
NEURON (2012)
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Wei Xu et al.
CANCER CELL (2011)
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
Rasheduzzaman Chowdhury et al.
EMBO REPORTS (2011)
Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures
Jihong Xu et al.
JOURNAL OF NEURO-ONCOLOGY (2011)
Adult hippocampal neurogenesis and its role in Alzheimer's disease
Yangling Mu et al.
MOLECULAR NEURODEGENERATION (2011)
Mapping and analysis of chromatin state dynamics in nine human cell types
Jason Ernst et al.
NATURE (2011)
Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells
F. Orzan et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2011)
GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
Craig H. Mermel et al.
GENOME BIOLOGY (2011)
Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa
Tomislav Domazet-Loso et al.
BMC BIOLOGY (2010)
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
Houtan Noushmehr et al.
CANCER CELL (2010)
A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs
Jonghwan Kim et al.
CELL (2010)
The Amphimedon queenslandica genome and the evolution of animal complexity
Mansi Srivastava et al.
NATURE (2010)
EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance
Mario-Luca Suva et al.
CANCER RESEARCH (2009)
Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study
Evanthia Galanis et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysis
G. Foltz et al.
ONCOGENE (2009)
Runx2 is expressed in human glioma cells and mediates the expression of galectin-3
Valentina Vladimirova et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2008)
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Alexander Meissner et al.
NATURE (2008)
Pathways to Tumorigenesis-Modeling Mutation Acquisition in Stem Cells and Their Progeny
Rina Ashkenazi et al.
NEOPLASIA (2008)
Lineage dependency and lineage-survival oncogenes in human cancer
Levi A. Garraway et al.
NATURE REVIEWS CANCER (2006)
Glutamate enhances survival and proliferation of neural progenitors derived from the subventricular zone
CY Brazel et al.
NEUROSCIENCE (2005)
CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinase
M Huang et al.
LEUKEMIA (2004)
Cell cycle regulation and neural differentiation
U Galderisi et al.
ONCOGENE (2003)
A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools
M Huang et al.
MOLECULAR PHARMACOLOGY (2002)
The cytostatic- and differentiation-inducing effects of cyclopentenyl cytosine on neuroblastoma cell lines
J Bierau et al.
BIOCHEMICAL PHARMACOLOGY (2001)