4.7 Review

Annexin A2: The diversity of pathological effects in tumorigenesis and immune response

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ

Ruo Chen et al.

Summary: Inhibition of CD147 on T cells can slow down thymic aging and increase production of naive T cells by slowing the EMT process in TECs. This mechanism involves the interaction between T cells and TECs, leading to reduced adipocyte accumulation and potential strategies to hinder age-related thymic involution by inhibiting TGF beta and CD147.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Medicine, General & Internal

Generation of osimertinib-resistant cells from epidermal growth factor receptor L858R/T790M mutant non-small cell lung carcinoma cell line

Nalini Devi Verusingam et al.

Summary: In this study, Osimertinib-resistant (OR) cells were generated from H1975 with L858R/T790M double mutation as a model to elucidate mechanism of resistance. OR cells showed increased drug resistance potential, mesenchymal features, and activation of EGFR-independent signaling, EMT, and autophagy, indicating the development of a model for understanding molecular aberration during acquired resistance mechanism.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2021)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Cell Biology

Annexin A2 regulates unfolded protein response via IRE1-XBP1 axis in macrophages during P. aeruginosa infection

Chuan-Min Zhou et al.

Summary: This study found that AnxA2 up-regulates the IRE1-XBP1 pathway through p38 MAPK signaling in macrophages infected with P. aeruginosa. XBP1 acts as a positive regulator of innate immunity, enhances autophagy and bacterial clearance, and facilitates NF-kappa B activation to release proinflammatory cytokines mainly in macrophages. These findings identify AnxA2 as a regulator for the XBP1-mediated UPR pathway.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

Review Chemistry, Medicinal

The role of hypoxia-inducible factor 1 in tumor immune evasion

Li You et al.

Summary: Hypoxia and HIF-1 are crucial in tumor immune evasion, suppressing the immune system to promote tumor growth and metastasis.

MEDICINAL RESEARCH REVIEWS (2021)

Article Biochemistry & Molecular Biology

(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells

Chen Chen et al.

Summary: 20S G-Rh2 inhibits the survival and proliferation of human liver cancer cells by targeting HSP90A and disturbing the HSP90A-Cdc37 chaperone system. This may make it a promising alternative drug for liver cancer therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection Complications

Prakash Patil et al.

Summary: SARS-CoV-2 has caused infections and deaths worldwide, with millions affected and no clinically proven antivirals available. Efforts to develop effective drugs are being delayed by mutations and lack of understanding of viral mechanisms. AnxA2 may play a potential role in SARS-CoV-2 pathogenesis and post-infection complications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Clinical Significance of Annexin A2 Expression in Breast Cancer Patients

Lee D. Gibbs et al.

Summary: Annexin A2 (AnxA2) is overexpressed in tumor tissues and serum samples of breast cancer patients, especially in the TNBC subtype, where its expression is associated with poor prognosis. The phosphorylation of AnxA2 at tyrosine 23 appears to be a critical step for its secretion from TNBC cells and could serve as a potential diagnostic biomarker in TNBC patients.

CANCERS (2021)

Article Rheumatology

Autoantibodies to Annexin A2 and cerebral thrombosis: Insights from a mouse model

Ronen Weiss et al.

Summary: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thromboembolic events, and antibodies to ANXA2 have been found to play a pathological role in thrombosis. The study demonstrates that antibodies to ANXA2 result in more severe strokes, supporting the hypothesis that these auto-antibodies are an independent risk factor for cerebral thrombosis.
Review Biochemistry & Molecular Biology

Molecular Targeting of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR)

Nichole E. M. Kaufman et al.

Summary: EGFR and VEGFR are frequently overexpressed membrane-bound receptor tyrosine kinase proteins in cancers, making them attractive targets for imaging and therapy. Inhibition modalities commonly used to target these receptors include TKIs, antibodies, and nanobodies. Recent advances in molecular imaging techniques, particularly near-IR fluorescence imaging, show promise for cancer detection and treatment.

MOLECULES (2021)

Article Multidisciplinary Sciences

Clinical significance of Annexin A2 expression in oral squamous cell carcinoma and its influence on cell proliferation, migration and invasion

Yingyi Ma et al.

Summary: ANXA2 is highly expressed in oral squamous cell carcinoma and is associated with poor survival. Silencing ANXA2 can suppress the proliferation, migration, and invasion of OSCC cells.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis

Linfeng Mao et al.

Summary: EphA2, YES1, and ANXA2 form a signaling axis that promotes gastric cancer invasion and metastasis. Overexpression of YES1 increases invasion and migration of gastric cancer cells, while knockdown of ANXA2 decreases these processes.

ONCOGENE (2021)

Review Immunology

T cells at work: How post-transcriptional mechanisms control T cell homeostasis and activation

Anouk P. Jurgens et al.

Summary: T cells play a central role in the adaptive immune system, protecting us from infections. Activation prompts T cells to change gene expression and produce effector molecules rapidly to combat threats. Dormant T cells regulate protein production to survive and prepare for potential re-infections.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Letter Respiratory System

Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients

Marisol Zuniga et al.

EUROPEAN RESPIRATORY JOURNAL (2021)

Review Cell Biology

Urokinase Plasminogen Activator: A Potential Thrombolytic Agent for Ischaemic Stroke

Rais Reskiawan A. Kadir et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2020)

Review Pharmacology & Pharmacy

Modulation of Ion Channels and Receptors by p11 (S100A10)

Ji-Seon Seo et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Review Gastroenterology & Hepatology

Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment

Li-Wei Qiu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

Article Biochemistry & Molecular Biology

(20S)G-Rh2 Inhibits NF-κB Regulated Epithelial-Mesenchymal Transition by Targeting Annexin A2

Yu-Shi Wang et al.

BIOMOLECULES (2020)

Review Cell Biology

Annexin A2 in Inflammation and Host Defense

Valentina Dallacasagrande et al.

Article Biochemistry & Molecular Biology

Slug and E-Cadherin: Stealth Accomplices?

Esta Sterneck et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Article Medicine, Research & Experimental

Roles of N-terminal Annexin A2 phosphorylation sites and miR-206 in colonic adenocarcinoma

Li Xiao et al.

LIFE SCIENCES (2020)

Review Immunology

Toll-Like Receptor Agonists as Adjuvants for Allergen Immunotherapy

Max E. Kirtland et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Cell Biology

The multifaceted role of plasminogen in inflammation

Beate Heissig et al.

CELLULAR SIGNALLING (2020)

Article Rheumatology

Insights into the diagnosis and pathogenesis of the antiphospholipid syndrome

Mohammad Hassan A. Noureldine et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2019)

Review Biochemistry & Molecular Biology

Cisplatin: The first metal based anticancer drug

Sumit Ghosh

BIOORGANIC CHEMISTRY (2019)

Review Oncology

Targeting mTOR for cancer therapy

Hui Hua et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Oncology

mTOR: Role in cancer, metastasis and drug resistance

Avaniyapuram Kannan Murugan

SEMINARS IN CANCER BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Cancer-associated fibroblasts promote epithelial-mesenchymal transition and EGFR-TKI resistance of non-small cell lung cancers via HGF/IGF-1/ANXA2 signaling

Yanmei Yi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Review Oncology

Treating p53 Mutant Aggregation-Associated Cancer

Mathumai Kanapathipillai

CANCERS (2018)

Article Oncology

ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis

Sai Ma et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Review Microbiology

Annexin A2 in Virus Infection

Julia R. Taylor et al.

FRONTIERS IN MICROBIOLOGY (2018)

Review Cell Biology

Annexin A2-mediated cancer progression and therapeutic resistance in nasopharyngeal carcinoma

Chang-Yu Chen et al.

JOURNAL OF BIOMEDICAL SCIENCE (2018)

Article Oncology

Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells

Xiaomin Feng et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

Article Hematology

Mechanism of plasmin generation by S100A10

Victoria A. Miller et al.

THROMBOSIS AND HAEMOSTASIS (2017)

Article Gastroenterology & Hepatology

Expression of annexin II in gastric carcinoma and its role in gastric cancer metastasis

Feng Han et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Review Biotechnology & Applied Microbiology

Transforming growth factor-: A therapeutic target for cancer

Sulsal Haque et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

Article Multidisciplinary Sciences

The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity

Yu-Shi Wang et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

Protein phosphorylation and its role in the regulation of Annexin A2 function

Ann Kari Grindheim et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

Review Biochemistry & Molecular Biology

The annexin A2 system and angiogenesis

Wei Liu et al.

BIOLOGICAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Annexins - insights from knockout mice

Thomas Grewal et al.

BIOLOGICAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

EMT: 2016

M. Angela Nieto et al.

Article Immunology

Pseudomonas aeruginosa promotes autophagy to suppress macrophage-mediated bacterial eradication

Yongjian Wu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

Article Immunology

Annexin A2, autoimmunity, anxiety and depression

R. Weiss et al.

JOURNAL OF AUTOIMMUNITY (2016)

Article Biotechnology & Applied Microbiology

Epithelial-mesenchymal transition: a new target in anticancer drug discovery

Fabrizio Marcucci et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Rheumatology

TNF-alpha and annexin A2: inflammation in thrombotic primary antiphospholipid syndrome

Mirjana Becarevic

RHEUMATOLOGY INTERNATIONAL (2016)

Article Oncology

Monomeric annexin A2 is an oxygen regulated toll-like receptor 2 ligand and adjuvant

Brian M. Andersen et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2016)

Article Oncology

Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma

Manabu Onishi et al.

BRAIN TUMOR PATHOLOGY (2015)

Article Oncology

Association of annexin A2 with cancer development (Review)

Xiao-Heng Xu et al.

ONCOLOGY REPORTS (2015)

Article Biochemical Research Methods

Autoantibodies targeting glomerular annexin A2 identify patients with proliferative lupus nephritis

Dawn J. Caster et al.

PROTEOMICS CLINICAL APPLICATIONS (2015)

Article Biochemistry & Molecular Biology

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

Kelly Foley et al.

SCIENCE SIGNALING (2015)

Review Hematology

Annexin A2 autoantibodies in thrombosis and autoimmune diseases

Felipe Canas et al.

THROMBOSIS RESEARCH (2015)

Article Oncology

Annexin A2 in renal cell carcinoma: Expression, function, and prognostic significance

Shun-Fa Yang et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2015)

Article Multidisciplinary Sciences

Annexin A2 as a target endothelial cell membrane autoantigen in Behcet's disease

Peng Chen et al.

SCIENTIFIC REPORTS (2015)

Article Biochemistry & Molecular Biology

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

Kelly Foley et al.

SCIENCE SIGNALING (2015)

Review Immunology

Mechanisms of kidney injury in lupus nephritis - the role of anti-dsDNA antibodies

Susan Yung et al.

FRONTIERS IN IMMUNOLOGY (2015)

Article Oncology

Annexin-A2 as predictor biomarker of recurrent disease in endometrial cancer

Lorena Alonso-Alconada et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

Article Biochemistry & Molecular Biology

Under-Expression of Annexin A2 is Associated With Kazakh's Esophageal Squamous Cell Carcinoma

Xiuling Li et al.

MOLECULAR CARCINOGENESIS (2015)

Review Biotechnology & Applied Microbiology

Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development

Chi-Yun Wang et al.

DISEASE MARKERS (2014)

Review Biochemistry & Molecular Biology

Annexin A2: The Importance of Being Redox Sensitive

Patricia A. Madureira et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Biochemistry & Molecular Biology

Annexin A2 Heterotetramer: Structure and Function

Alamelu Bharadwaj et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Hematology

Annexin A2 System in Human Biology: Cell Surface and Beyond

Min Luo et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2013)

Article Gastroenterology & Hepatology

Annexin A2 silencing inhibits invasion, migration, and tumorigenic potential of hepatoma cells

Hai-Jian Zhang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

Article Oncology

The association of annexin A2 and cancers

Xiaohui Zhang et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2012)

Article Biochemistry & Molecular Biology

Annexin A2 and A5 Serve as New Ligands for C1q on Apoptotic Cells

Myriam Martin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Basic and Therapeutic Aspects of Angiogenesis

Michael Potente et al.

Article Otorhinolaryngology

CLINICAL SIGNIFICANCE OF ANNEXIN A2 DOWNREGULATION IN ORAL SQUAMOUS CELL CARCINOMA

Juan P. Rodrigo et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2011)

Article Biochemistry & Molecular Biology

Feedback Regulation of Endothelial Cell Surface Plasmin Generation by PKC-dependent Phosphorylation of Annexin A2

Kai-Li He et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Pharmacology & Pharmacy

The annexin A2 system and vascular homeostasis

Elle C. Flood et al.

VASCULAR PHARMACOLOGY (2011)

Article Urology & Nephrology

Anti-dsDNA Antibodies Bind to Mesangial Annexin II in Lupus Nephritis

Susan Yung et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Review Immunology

Complement: a key system for immune surveillance and homeostasis

Daniel Ricklin et al.

NATURE IMMUNOLOGY (2010)

Article Medicine, General & Internal

Gefitinib or Chemotherapy for Non-Small-Cell Lung Cancer with Mutated EGFR.

Makoto Maemondo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Cell Biology

Annexins - Modulators of EGF receptor signalling and trafficking

Thomas Grewal et al.

CELLULAR SIGNALLING (2009)

Article Biochemistry & Molecular Biology

Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer

Farhad Vesuna et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Biochemistry & Molecular Biology

Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11

Kai-Li He et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Immunology

Anti-annexin II antibodies in systemic autoimmune diseases and antiphospholipid syndrome

V. Salle et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2008)

Review Oncology

Diagnosing and exploiting cancer's addiction to blocks in apoptosis

Anthony G. Letai

NATURE REVIEWS CANCER (2008)

Article Multidisciplinary Sciences

Suppression of p53-dependent senescence by the JNK signal transduction pathway

Madhurnita Das et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Oncology

Hypoxia inducible factor-1-independent pathways in tumor angiogenesis

Yusuke Mizukami et al.

CLINICAL CANCER RESEARCH (2007)

Article Cell Biology

Regulation of nucleo-cytoplasmic shuttling of human annexin A2-a proposed mechanism

Jie Liu et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2007)

Article Hematology

Plasmin triggers cytokine induction in human monocyte-derived macrophages

Qun Li et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)

Review Biochemistry & Molecular Biology

Hydrogen peroxide sensing and signaling

Elizabeth A. Veal et al.

MOLECULAR CELL (2007)

Article Biochemistry & Molecular Biology

Annexin A2 recognises a specific region in the 3′-UTR of its cognate messenger RNA

Hanne Hollas et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2006)

Review Oncology

Fibroblasts in cancer

R Kalluri et al.

NATURE REVIEWS CANCER (2006)

Article Biochemistry & Molecular Biology

Annexin A2 binds to the localization signal in the 3 ' untranslated region of c-myc mRNA

I Mickleburgh et al.

FEBS JOURNAL (2005)

Article Biochemistry & Molecular Biology

Annexin 2 expression is reduced in human osteosarcoma metastases

JM Gillette et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2004)

Review Biotechnology & Applied Microbiology

The annexins

SE Moss et al.

GENOME BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Secretion of annexin II via activation of insulin receptor and insulin-like growth factor receptor

WQ Zhao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)