期刊
INTERNATIONAL JOURNAL OF CANCER
卷 151, 期 4, 页码 497-509出版社
WILEY
DOI: 10.1002/ijc.34048
关键词
anti-ANXA2 antibodies; ANXA2 function; ANXA2 heterotetramer; ANXA2 monomers; phosphorylated ANXA2
类别
资金
- General Projects of National Natural Science Foundation of China [82174187]
- Key Research and Promotion Project of Henan Province (Technology Research) [212102310358]
- Leading Talent Project of Traditional Chinese Medicine in Henan Province [8]
ANXA2 is widely used as a marker in various tumors. It plays a role in tumorigenesis and immune response by regulating multiple signal pathways. It is involved in tumor cell invasion and metastasis, angiogenesis, and the expression of inflammatory factors. It also mediates immune response through its interaction with pathogens and antibodies.
Annexin A2 (ANXA2) is widely used as a marker in a variety of tumors. By regulating multiple signal pathways, ANXA2 promotes the epithelial-mesenchymal transition, which can cause tumorigenesis and accelerate thymus degeneration. The elevated ANXA2 heterotetramer facilitates the production of plasmin, which participates in pathophysiologic processes such as tumor cell invasion and metastasis, bleeding diseases, angiogenesis, inducing the expression of inflammatory factors. In addition, the ANXA2 on the cell membrane mediates immune response via its interaction with surface proteins of pathogens, C1q, toll-like receptor 2, anti-dsDNA antibodies and immunoglobulins. Nuclear ANXA2 plays a role as part of a primer recognition protein complex that enhances DNA synthesis and cells proliferation by acting on the G1-S phase of the cell. ANXA2 reduction leads to the inhibition of invasion and metastasis in multiple tumor cells, bleeding complications in acute promyelocytic leukemia, retinal angiogenesis, autoimmunity response and tumor drug resistance. In this review, we provide an update on the pathological effects of ANXA2 in both tumorigenesis and the immune response. We highlight ANXA2 as a critical protein in numerous malignancies and the immune host response.
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