☆ 4.7 Article

N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pharmacology & Pharmacy

Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy

Xue Liu et al.

Summary: A nanocarrier material based on angelica polysaccharide was synthesized to target liver cancer in a hypoxic microenvironment and selectively enhance ferroptosis in solid tumors. The amphiphilic polymer micelles AAAF were confirmed to release drugs in response to hypoxia, showing potential for sensitizing ferroptosis and anti-tumor effects.

DRUG DELIVERY (2022)

添加到收藏夹

Review Gastroenterology & Hepatology

Cardiovascular Risk Assessment and Impact of Medications on Cardiovascular Disease in Inflammatory Bowel Disease

Preetika Sinh et al.

Summary: Patients with chronic inflammatory disorders have an increased risk of cardiovascular disease, with certain medications potentially reducing inflammation but also posing risks for cardiovascular issues.

INFLAMMATORY BOWEL DISEASES (2021)

添加到收藏夹

Article Plant Sciences

Novel Chinese Angelica Polysaccharide Biomimetic Nanomedicine to Curcumin Delivery for Hepatocellular Carcinoma Treatment and Immunomodulatory Effect

Chunjing Guo et al.

Summary: The combination of angelica polysaccharide and curcumin in functionalized nanoparticles showed enhanced synergistic anti-hepatoma effects both in vitro and in vivo, with increased immunomodulatory effects and stronger tumor tissue targeting ability. Therefore, APS nanocarriers encapsulated with erythrocyte membrane could be a promising clinical method for liver cancer therapy.

PHYTOMEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

AMPK S-sulfuration contributes to H2S donors-induced AMPK phosphorylation and autophagy activation in dopaminergic cells

Xiao-Ou Hou et al.

Summary: This study found that exogenous H2S donors can enhance autophagic flux through the AMPK-mTOR signaling pathway, thus reducing the accumulation of alpha-synuclein in dopaminergic cells.

NEUROCHEMISTRY INTERNATIONAL (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases

Angela Corvino et al.

Summary: Hydrogen sulfide (H2S) is an endogenous gasotransmitter that has emerged as an important regulatory mediator in numerous human cell functions. It plays a significant role in various physio-pathological processes and the protective effects of H2S donors have been extensively studied in different disease models. The growing interest in H2S-releasing compounds highlights their potential as promising drugs for the treatment of cardiovascular diseases.

ANTIOXIDANTS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Effects of gut microbiota on atherosclerosis through hydrogen sulfide

Dan-Dan Gui et al.

Summary: Cardiovascular diseases, particularly atherosclerotic cardiovascular disease (ASCVD), are heavily influenced by environmental and genetic factors. Disruption of the human gut flora microenvironment is associated with various health problems, while hydrogen sulfide (H2S) plays crucial regulatory roles in the cardiovascular system, offering potential therapeutic direction for atherosclerosis.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Plug and Play Functionalized Erythrocyte Nanoplatform for Target Atherosclerosis Management

Yuan Zhong et al.

Summary: A nanoplatform based on red blood cells was developed for targeted drug delivery and controlled release for atherosclerosis treatment, addressing challenges such as low location specificity and side effects.

ACS APPLIED MATERIALS & INTERFACES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Liposomes with Water as a pH-Responsive Functionality for Targeting of Acidic Tumor and Infection Sites

Da-Yuan Wang et al.

Summary: DCPA-H2O liposomes with high protonation capability demonstrated enhanced targeting to solid tumors and intra-abdominal infectious biofilms in murine models. Additionally, therapeutic efficacy of ciprofloxacin-loaded DCPA-H2O liposomes in infected wound-healing model exceeded that of clinically applied ciprofloxacin and other liposomes loaded with ciprofloxacin.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Renal Clearable Ultrasmall Single-Crystal Fe Nanoparticles for Highly Selective and Effective Ferroptosis Therapy and Immunotherapy

Huan Liang et al.

Summary: This study synthesized ultrasmall single-crystal Fe nanoparticles that showed high activity in inducing tumor cell ferroptosis and immunogenetic cell death in the tumor microenvironment at a low concentration. These nanoparticles effectively suppressed tumor growth, promoted dendritic cell maturation, and triggered T cell response in animal models, and when combined with immune checkpoint blockade therapy, they greatly enhanced the immune response and developed strong immune memory. Furthermore, the nanoparticles were quickly excreted in the kidneys without side effects in normal tissues.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ferroptosis-Strengthened Metabolic and Inflammatory Regulation of Tumor-Associated Macrophages Provokes Potent Tumoricidal Activities

Zhengying Gu et al.

Summary: This study demonstrates that an iron-based metal organic framework nanoparticle and a ferroptosis-inducing agent synergistically induce mitochondrial alternation in TAMs, resulting in a radical metabolic switch from mitochondrial oxidative phosphorylation to glycolysis, which is resistant to anti-inflammatory stimuli challenge. The ferroptosis stress strengthened by the nanoformulation also drives multiple pro-inflammatory signaling pathways, enabling macrophage activation with potent tumoricidal activities. The ferroptosis-strengthened macrophage regulation strategy present in this study paves the way for TAM-centered antitumoral treatment to overcome the limitations of conventional methods.

NANO LETTERS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Real-Time Imaging of Hepatic Inflammation Using Hydrogen Sulfide-Activatable Second Near-Infrared Luminescent Nanoprobes

Qin Liu et al.

Summary: The study introduces a turn-on second near-infrared (NIR-II) luminescent approach for sensitive, real-time, and in situ detection of hydrogen sulfide (H2S) in vivo. This method relies on the competitive absorption between H2S-responsive chromophores and NIR-II luminescent lanthanide nanoparticles, allowing for the monitoring of endogenous H2S in lipopolysaccharide-induced liver inflammation.

NANO LETTERS (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Novel glycoproteins identify preclinical atherosclerosis among women with previous preeclampsia regardless of type 1 diabetes status

Antonio J. Amor et al.

Summary: The study found that high H-1-NMR-glycoprotein concentrations have a negative impact on carotid atherosclerosis in women with preeclampsia, regardless of their type 1 diabetes status. White blood cells and hsCRP were not related to atherosclerosis.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Theranostic nanoplatform to target macrophages enables the inhibition of atherosclerosis progression and fluorescence imaging of plaque in ApoE(-/-) mice

Qi Wang et al.

Summary: The study presented the development of composite mesoporous silica nanoparticle-based nanomedicines for accurate diagnosis and treatment of atherosclerosis. The designed CMSN@SRT@Anti showed excellent biocompatibility, high-performance, and superior atherosclerosis-targeting ability. Animal experimental results demonstrated significant improvements in aortic plaque status and area after treatment with CMSN@SRT@Anti.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Intersection Between Chronic Kidney Disease and Cardiovascular Disease

Luke J. Laffin et al.

Summary: Chronic kidney disease and cardiovascular disease share common risk factors and pathogenic mechanisms, impacting a significant segment of the population. Patients with chronic kidney disease are more prone to develop cardiovascular disease, highlighting the importance of addressing the intersection between the two conditions.

CURRENT CARDIOLOGY REPORTS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications

Yi Wang et al.

Summary: This study aimed to develop an ideal biomimetic nanoparticle for targeted atherosclerosis (AS) therapy. The results showed that the advanced MM/RAPNPs demonstrated good biocompatibility, effectively inhibited the progression of AS, and displayed favorable safety performance in AS mouse models. These biomimetic nanoparticles may be potential drug delivery systems for safe and effective anti-AS applications.

THERANOSTICS (2021)

添加到收藏夹

Article Chemistry, Applied

Novel dual ROS-sensitive and CD44 receptor targeting nanomicelles based on oligomeric hyaluronic acid for the efficient therapy of atherosclerosis

Xiaoya Hou et al.

CARBOHYDRATE POLYMERS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines

Cheng Gao et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Chemistry, Medicinal

Hydrogen sulfide donors: Therapeutic potential in anti-atherosclerosis

Honghua Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Review Polymer Science

pH-Responsive Polymer Nanoparticles for Drug Delivery

Nayeleh Deirram et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Golgi Apparatus-Targeted Chondroitin-Modified Nanomicelles Suppress Hepatic Stellate Cell Activation for the Management of Liver Fibrosis

Jingwen Luo et al.

ACS NANO (2019)

添加到收藏夹

Article Chemistry, Physical

Determination of the critical micelle concentration by absorbance and fluorescence techniques using fluorescein probe

Jamil K. Salem et al.

CHEMICAL PHYSICS LETTERS (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Nanomedicine formulations for the delivery of antiviral drugs: a promising solution for the treatment of viral infections

David Lembo et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

添加到收藏夹

Article Chemistry, Applied

CD44-targeted hyaluronic acid-curcumin prodrug protects renal tubular epithelial cell survival from oxidative stress damage

Jing-Bo Hu et al.

CARBOHYDRATE POLYMERS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

The role of oxidative stress and NADPH oxidase in the pathogenesis of atherosclerosis

Dorota Bryk et al.

Postepy Higieny I Medycyny Doswiadczalnej (2017)

添加到收藏夹

Article Engineering, Biomedical

Non-proinflammatory and responsive nanoplatforms for targeted treatment of atherosclerosis

Yin Dou et al.

BIOMATERIALS (2017)

添加到收藏夹

Article Engineering, Biomedical

Nanoparticles responsive to the inflammatory microenvironment for targeted treatment of arterial restenosis

Shibin Feng et al.

BIOMATERIALS (2016)

添加到收藏夹

Article Engineering, Biomedical

A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease

Qixiong Zhang et al.

BIOMATERIALS (2016)

添加到收藏夹

Article Engineering, Biomedical

Micellar and structural stability of nanoscale amphiphilic polymers: Implications for anti-atherosclerotic bioactivity

Yingyue Zhang et al.

BIOMATERIALS (2016)

添加到收藏夹

Article Immunology

Pubertal Development in Pediatric Kidney Transplant Patients Receiving Mammalian Target of Rapamycin Inhibitors or Conventional Immunosuppression

Julia Foerster et al.

TRANSPLANTATION (2016)

添加到收藏夹

Article Engineering, Biomedical

Improved intervention of atherosclerosis and cardiac hypertrophy through biodegradable polymer-encapsulated delivery of glycosphingolipid inhibitor

S. Mishra et al.

BIOMATERIALS (2015)

添加到收藏夹

Article Engineering, Biomedical

ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease

Kristin M. Poole et al.

BIOMATERIALS (2015)

添加到收藏夹

Article Polymer Science

In vitro and in vivo evaluation of PEG-conjugated ketal-based chitosan micelles as pH-sensitive carriers

Daquan Chen et al.

POLYMER CHEMISTRY (2015)

添加到收藏夹

Review Chemistry, Analytical

Applications of micelle enhancement in luminescence-based analysis

Nawal A. Alarfaj et al.

LUMINESCENCE (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Nanoparticle-Mediated Delivery of Pitavastatin Inhibits Atherosclerotic Plaque Destabilization/Rupture in Mice by Regulating the Recruitment of Inflammatory Monocytes

Shunsuke Katsuki et al.

CIRCULATION (2014)

添加到收藏夹

Review Immunology

The effects of rapamycin on regulatory T cells: Its potential time-dependent role in inducing transplant tolerance

Juan Shan et al.

IMMUNOLOGY LETTERS (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension

Amal Houssaini et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

添加到收藏夹

Article Hematology

Rapamycin Inhibits Smooth Muscle Cell Proliferation and Obstructive Arteriopathy Attributable to Elastin Deficiency

Wei Li et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

添加到收藏夹

Article Engineering, Biomedical

Current Progress in Reactive Oxygen Species (ROS)-Responsive Materials for Biomedical Applications

Sue Hyun Lee et al.

ADVANCED HEALTHCARE MATERIALS (2013)

添加到收藏夹

Review Immunology

Macrophages in atherosclerosis: a dynamic balance

Kathryn J. Moore et al.

NATURE REVIEWS IMMUNOLOGY (2013)

添加到收藏夹

Review Pharmacology & Pharmacy

Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications

Emanuel Fleige et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

添加到收藏夹

Article Gastroenterology & Hepatology

An Orally Administered Redox Nanoparticle That Accumulates in the Colonic Mucosa and Reduces Colitis in Mice

Long Binh Vong et al.

GASTROENTEROLOGY (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Endogenous hydrogen sulfide is involved in the pathogenesis of atherosclerosis

Wang Qiao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

添加到收藏夹

Article Medicine, Research & Experimental

Multimodal Clinical Imaging To Longitudinally Assess a Nanomedical Anti-Inflammatory Treatment in Experimental Atherosclerosis

Mark E. Lobatto et al.

MOLECULAR PHARMACEUTICS (2010)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.