期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 208, 期 -, 页码 196-207出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.03.082
关键词
Sargassum pallidum; Polysaccharide; Nanoparticles; Antisolvent precipitation; Antioxidant activity
资金
- National Natural Science Foundation of China [31801542]
- Natural Science Foundation of Guangdong Province, China [2022A1515010448]
- Science and Technology Program of Guangzhou [202102020267]
- Fundamental Research Funds for the Central Universities of China [2020ZYGXZR021]
Sargassum pallidum polysaccharide nanoparticles were successfully prepared using antisolvent precipitation method with optimized conditions. Nanocrystallization did not alter the primary and crystal structures of the polysaccharide, but improved its properties, suggesting nSPP-30's potential as an antioxidant or nano-carrier.
Sargassum pallidum polysaccharide nanoparticle (nSPP-30) was prepared via antisolvent precipitation method and the preparation conditions were optimized. The effects of nanocrystallization on the structure and biological activities of S. pallidum polysaccharide were investigated. Under the optimal preparation condition, the average particle size, polydispersity index (PDI), and xi-potential of nSPP-30 were 229.63 nm, 0.407, and-28.43 mV, respectively. Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) analyses indicated that nanocrystallization did not change primary and crystal structures of S. pallidum polysaccharide. However, nanocrystallization could improve the swelling, thermodynamic, and antioxidant properties of S. pallidum polysaccharide. In addition, the thymol adsorption capacity of nSPP-30 was enhanced as compared to the cor-responding polysaccharide. These results suggest that nSPP-30 can be developed as a potential antioxidant or natural nano-carrier to encapsulate thymol for practical applications.
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