期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 208, 期 -, 页码 586-595出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.03.141
关键词
Chitosan; Schiff base; Antifungal activity
资金
- National Key Research and Development Program of China [2019YFD1002704-01]
- Youth Innovation Promotion Association CAS [2020219]
- Chinese Academy of Sciences
Chitosan derivatives modified with Schiff base bearing benzenoid/heterocyclic moieties were successfully prepared via amidation reaction. The introduction of functional groups greatly enhanced the antifungal and antioxidant activities of the derivatives, making them potential biomaterials for anti-fungal and antioxidant applications.
In this work, chitosan derivatives modified with Schiff base bearing benzenoid/heterocyclic moieties were successfully prepared via amidation reaction. Specific structural characterization was implemented using FTIR and H-1 NMR, and the DS of chitosan derivatives were quantitatively calculated by ratio of hydrogen proton integral. Meanwhile, the antifungal activity against two common plant pathogenic fungi (Fusarium oxysporum f. sp. cubense and Glomerella cingulata) was assayed in vitro by hyphal measurement, and data proved that the introduction of functional groups including benzene/heterocyclic compounds and Schiff base groups greatly enhanced the antifungal activity. Besides, the antioxidant efficiency was investigated in vitro, and all chitosan derivatives exhibited significantly increased antioxidant activity. Specially, the scavenging effect of 2SATCS was 96.62% at 1.6 mg/mL, which was close to the positive control VC (98.84%). These results indicated that chitosan derivatives with enhanced antifungal and antioxidant activities could serve as potential biomaterial for anti-fungal and antioxidant applications.
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