期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 200, 期 -, 页码 593-617出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.01.115
关键词
Amyloids; Alzheimer's; Parkinson's; Functional amyloids; Curli fibrils
资金
- DBT, New Delhi, India
- MANF
- DBT [BT/PR32907/MED/122/227/2019]
Proteins and their aggregation are important in the study of neurodegenerative diseases and have both disease-related and functional roles. This review discusses the role of amyloids in diseases like Alzheimer's and Parkinson's, as well as their functional roles in various biological processes. The transformation of amyloids from being considered harmful to being recognized as having beneficial functions is also explored.
Proteins and their aggregation is significant field of research due to their association with various conformational maladies including well-known neurodegenerative diseases like Alzheimer's (AD), Parkinson's (PD), and Hun-tington's (HD) diseases. Amyloids despite being given negative role for decades are also believed to play a functional role in bacteria to humans. In this review, we discuss both facets of amyloid. We have shed light on AD, which is one of the most common age-related neurodegenerative disease caused by accumulation of A beta fibrils as extracellular senile plagues. We also discuss PD caused by the aggregation and deposition of alpha-synuclein in form of Lewy bodies and neurites. Other amyloid-associated diseases such as HD and amyotrophic lateral sclerosis (ALS) are also discussed. We have also reviewed functional amyloids that have various biological roles in both prokaryotes and eukaryotes that includes formation of biofilm and cell attachment in bacteria to hormone storage in humans, We discuss in detail the role of Curli fibrils' in biofilm formation, chaplins in cell attachment to peptide hormones, and Pre-Melansomal Protein (PMEL) roles. The disease-related and functional amyloids are compared with regard to their structural integrity, variation in regulation, and speed of forming aggregates and elucidate how amyloids have turned from foe to friend.
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