期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 209, 期 -, 页码 50-58出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.03.089
关键词
P-L-MMT hydrogel; Lycium barbarum L; polysaccharides; Hemostasis and wound healing
资金
- National Key Research and Development Program of China [2018YFE0127000]
- National Natural Science Foundation of China [21675127, 31901794]
- Shaanxi Provincial Science Fund for Distinguished Young Scholars [2018JC-011]
- Qinghai Special Project of Innovation Platform for Basic Conditions of Scientific Research of China [2022-ZJ-Y18]
- Qinghai Provincial Key Laboratory of Qinghai-Tibet Plateau Biological Resource [2021-ZJ-Y14]
- National Postdoctoral Program for Innovative Talents [BX20180263]
- Tang Scholar by Cyrus Tang Foundation
A hemostatic hydrogel loaded with Lycium barbarum L. polysaccharide-functionalized ultrathin MMT nanosheets was developed for efficient hemostasis and wound healing, showing outstanding hemostasis activity and anti-inflammatory effects. This inexpensive and versatile nanostructure holds great promise in nanomedicine applications.
Designing wound dressing materials with hemocompatibility, suitable mechanical properties, outstanding he-mostatic effects and anti-inflammatory activity is of great practical significance for wound management. Herein, a hemostatic hydrogel loaded with Lycium barbarum L. polysaccharide (LBP)-functionalized ultrathin MMT nanosheets (L-MMT NSs) was fabricated for efficient hemostasis and wound healing. Loading the L-MMT NSs into polyvinyl alcohol (PVA), the obtained P-L-MMT hydrogel exhibited a 3D porous structure with good swelling properties, cytocompatibility, hemocompatibility, and anti-inflammatory activity. Importantly, in vivo in-vestigations demonstrated that the P-L-MMT hydrogel exerts outstanding hemostasis activity in the hemor-rhaging mouse liver model and reduces tissue damage caused by inflammation to shorten wound healing time. Altogether, the convenient exfoliation and functionalization of bulk MMT using LBPs make this inexpensive and rising nanostructure more attractive in the application of nanomedicine. Moreover, due to the synergy between hemostasis and anti-inflammation, this newly developed multifunctional P-L-MMT hydrogel represents a promising material in biomedical fields.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据