期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 201, 期 -, 页码 592-606出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.01.039
关键词
Functional nucleic acid; Biosensor; Carbohydrate
资金
- Natural Science Foundation of Jiangsu Province [BK20200718]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [20KJB350010]
- Jiangsu Innovation and Entrepreneurship Doctoral Program
- Jiangsu Specially-Appointed Professor Project
This review discusses the roles of carbohydrates and glycoconjugates in organisms and the applications of FNAs-based biosensors in detecting disease-related substances. By summarizing construction strategies and biosensing applications, challenges and development opportunities in this area are highlighted.
As significant components of the organism, carbohydrates and glycoconjugates play indispensable roles in energy supply, cell signaling, immune modulation, and tumor cell invasion, and function as biomarkers since aberrance of them has been proved to be associated with the emergence and development of certain diseases. Functional nucleic acids (FNAs) have properties including easy-to-synthesize, good stability, good biocompatibility, low cost, and high programmability, they have attracted significant research attention and been incorporated into biosensors for detecting disease-related carbohydrates and glycoconjugates. This review summarizes the construction strategies and biosensing applications of FNAs-based biosensors in glycobiology in terms of target recognition and signal transduction. By illustrating the mechanisms and comparing the performances, the challenges and development opportunities in this area have been critically elaborated. We believe that this review will provide a better understanding of the role of FNAs in the analysis of disease-related carbohydrates and glycoconjugates, and inspire further discovery in fields that include glycobiology, chemical biology, clinical diagnosis, and drug development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据