期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 146, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2022.106196
关键词
Myocardial infarction; Cardiac remodeling; Angiogenesis; Syndecan; Cardiac fibrosis
资金
- Dunhill Medical Trust [RPGF1906\173]
- Macular Society
The purpose of this review is to explore the biological insights into the role of Syndecan-4 in both the injured heart and later during cardiac repair and remodeling.
The heparan sulphate proteoglycan Syndecan-4 belongs to a 4-member family of transmembrane receptors. Genetic deletion of Syndecan-4 in mice causes negligible developmental abnormalities however when challenged these animals show distinct phenotypes. Synedcan-4 is expressed in many cell types in the heart and its expression is elevated in response to cardiac injury and recent studies have suggested roles for Syndecan-4 in repair mechanisms within the damaged heart. The purpose of this review is to explore these biological insights into the role of Syndecan-4 in both the injured heart and later during cardiac repair and remodeling.
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