4.7 Article

The contribution of neuro-immune crosstalk to pain in the peripheral nervous system and the spinal cord

期刊

INTERNATIONAL IMMUNOPHARMACOLOGY
卷 107, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.intimp.2022.108700

关键词

Pain; Neuroimmune; Macrophages; Mast cells; Neutrophils; T cells

资金

  1. National Natural Science Foundation of China [81100822, 81671089, 82071239]
  2. Zhejiang Pro-vincial Natural Science Foundation of China [LY22H090003]
  3. Major program of Ningbo Science and Technology Innovation [2025 (2019B10067)]

向作者/读者索取更多资源

Pain is an unpleasant sensation associated with injury, inflammation, and infection, and communication between immune cells and neurons plays a crucial role in its development. Understanding the mechanisms of neuroimmune interaction helps to comprehend the pathogenesis of pain-related diseases and develop effective medications.
Pain is an unpleasant sensation associated with injury, inflammation, and infection. It has been demonstrated that communication between immune cells and neurons plays a vital role in pain and pain-related diseases (e.g. multiple sclerosis, osteoarthritis, irritable bowel syndrome). Growing data from preclinical and clinical studies have established that the bilateral regulations between peripheral immune cells and nociceptive neurons could be beneficial or detrimental for the development of pain and immune defense. We here review the mechanisms underlying neuroimmune crosstalk between circulating immune cells (e.g. macrophages, T cells, mast cells, neutrophils, monocytes) and nociceptors in the peripheral nervous system and the spinal cord. Deciphering the mechanisms by which neuroimmune interaction integrates neuronal inputs and immune responses helps to understand the pathogenesis of pain-related diseases and develop effective medications.

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