期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 106, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2022.108638
关键词
Ethanol; Brain injury; Methylsulfonylmethane; Inflammation; Apoptosis; Oxidative stress
Excessive ethanol consumption can cause brain injury, but this study found that methylsulfonylmethane (MSM) has a protective effect against ethanol-induced brain injury. MSM reduces oxidative stress and inflammation, increases antioxidant levels, and decreases apoptosis-related proteins. These findings suggest that MSM may be a potential approach to prevent brain damage caused by high levels of alcohol.
Excessive ethanol consumption causes brain injury through oxidative stress, inflammation and apoptotic cell death. Methylsulfonylmethane (MSM) is a natural compound that has therapeutic effects on oxidative and in-flammatory disorders. The aim of this study was to investigate the protective effect and underlying mechanisms of MSM on ethanol-induced brain injury in an experimental model. Male C57BL/6 mice were exposed to binge ethanol (5 g/kg/day, orally) and treated with MSM (200 and 400 mg/kg/day) concomitantly for 12 days. At the end of the experiment brain tissues were removed for histological and biochemical analysis. The results showed that MSM reduced ethanol-mediated oxidative stress by decreasing the levels of malondialdehyde (MDA) and carbonyl protein. The Nrf2/HO-1 pathway and the levels of cytoprotective antioxidants superoxide dismutase (SOD), catalase and glutathione (GSH) were increased by MSM in the brain tissue. MSM treatment reduced the ethanol-induced inflammatory factors including myeloperoxidase (MPO), iNOS/NO, cyclooxygenase (COX)-2, nuclear factor kappa B (NF-kappa B), NLRP3 inflammasome and proinflammatory cytokines including TNF-alpha, IL-1 beta, IL-6 and MCP-1. MSM also decreased the levels of pro-apoptotic caspase-3 and TUNEL positive cells while increased the level of anti-apoptotic Bcl-2 in the brain tissue. Our findings demonstrated that MSM protects against ethanol-induced brain injury by improving anti-oxidant defense mechanism and reducing ethanol-mediated inflammation and apoptosis. Therefore, MSM may be a potential protective approach for brain dam-age caused by high levels of alcohol.
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