4.7 Article

Correlation between sensitization to house dust mite major allergens, age, and symptoms in Japanese house dust mite allergic subjects

期刊

INTERNATIONAL IMMUNOPHARMACOLOGY
卷 107, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.intimp.2022.108640

关键词

Allergen component; AR symptom score; Der p 23; House dust mite; Japanese allergic patients

资金

  1. Torii Pharmaceutical Co. Ltd

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In Japanese HDM allergic rhinitis patients without asthma, there is a high prevalence of allergic sensitization to the HDM major allergens Der p 1, Der p 2, and Der p 23, with a significantly higher prevalence of Der p 23 sensitization in the younger age group. However, there was no significant correlation found between AR symptom scores and concentration of s-IgE towards Der p extract and any of the three HDM major allergens in this population.
Der p 23 has recently been recognized as a new house dust mite (HDM) major allergen that may be linked to the development of asthma in HDM allergic patients. This study aimed to investigate the frequency of sensitization to HDM major allergen components including Der p 23 and to examine the correlation between HDM-sensitization and AR symptom score in Japanese HDM allergic rhinitis (AR) patients without allergic asthma. Serum samples (n = 120) collected from Japanese HDM AR patients (12 to 64 years) without asthma were assessed for allergen-specific IgE (s-IgE) by ImmunoCAP (Dermatophagoides pteronyssinus (D. pteronyssinus; Der p) extract, Der p 23) or immunosolid-phase allergen chip (Der p 1, Der p 2). Japanese HDM AR patients without asthma showed a high prevalence of allergic sensitization to the HDM major allergens Der p 1 (94.2%), Der p 2 (97.5%) and Der p 23 (71.7%). No difference in the prevalence was detected for Der p 1 and Der p 2 s-IgE among three age groups. However, the prevalence of Der p 23 s-IgE was significantly higher in the younger group compared to the elderly group. No significant correlation was found between AR symptom scores and concentration of s-IgE towards Der p extract and any of the three HDM major allergens. Although the prevalence of sensitization towards D. pteronyssinus major allergens is high in Japanese AR patients without asthma, there was no correlation between allergen specific IgE including IgE towards Der p 23 and AR symptom in this population.

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