期刊
INFLUENZA AND OTHER RESPIRATORY VIRUSES
卷 16, 期 6, 页码 1072-1081出版社
WILEY
DOI: 10.1111/irv.13004
关键词
hospitalization; influenza; mortality; respiratory syncytial virus; SARS-CoV-2
资金
- Canadian Institutes of Health Research [VR5-172683, PJT-159516]
- St. Michael's Hospital Foundation
- ICES - Ontario Ministry of Health (MOH)
- Ministry of Long-Term Care (MLTC)
- Public Health Ontario
- Ontario Health Data Platform (OHDP), a Province of Ontario initiative
Our study identified shared and divergent predictors of clinical severity across different respiratory viruses, including age, gender, chronic kidney disease, etc. Notably, the positive association between age and mortality was largest for patients with SARS-CoV-2 compared to influenza or RSV patients.
Background Shared and divergent predictors of clinical severity across respiratory viruses may support clinical and community responses in the context of a novel respiratory pathogen. Methods We conducted a retrospective cohort study to identify predictors of 30-day all-cause mortality following hospitalization with influenza (N = 45,749; 2010-09 to 2019-05), respiratory syncytial virus (RSV; N = 24 345; 2010-09 to 2019-04), or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; N = 8988; 2020-03 to 2020-12; pre-vaccine) using population-based health administrative data from Ontario, Canada. Multivariable modified Poisson regression was used to assess associations between potential predictors and mortality. We compared the direction, magnitude, and confidence intervals of risk ratios to identify shared and divergent predictors of mortality. Results A total of 3186 (7.0%), 697 (2.9%), and 1880 (20.9%) patients died within 30 days of hospital admission with influenza, RSV, and SARS-CoV-2, respectively. Shared predictors of increased mortality included older age, male sex, residence in a long-term care home, and chronic kidney disease. Positive associations between age and mortality were largest for patients with SARS-CoV-2. Few comorbidities were associated with mortality among patients with SARS-CoV-2 as compared with those with influenza or RSV. Conclusions Our findings may help identify patients at greatest risk of illness secondary to a respiratory virus, anticipate hospital resource needs, and prioritize local prevention and therapeutic strategies to communities with higher prevalence of risk factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据