COVID-19 severity from Omicron and Delta SARS-CoV-2 variants

The Omicron variant of SARS-CoV-2 achieved worldwide dominance in late 2021. Early work suggests that infections caused by the Omicron variant may be less severe than those caused by the Delta variant. We sought to compare clinical outcomes of infections caused by these two strains, confirmed by whole genome sequencing, over a short period of time, from respiratory samples collected from SARS-CoV-2 positive patients at a large medical center. We found that infections caused by the Omicron variant caused significantly less morbidity, including admission to the hospital and requirement for oxygen supplementation, and significantly less mortality than those caused by the Delta variant.

Automated summary

The clinical outcomes of infections caused by the Omicron variant were compared to those caused by the Delta variant. It was found that infections caused by the Omicron variant were less severe, with significantly lower morbidity and mortality rates, compared to those caused by the Delta variant.