Lactylation: a Passing Fad or the Future of Posttranslational Modification

Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and diseases. Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation regulates oncogenic processes by targeting gene transcription and inflammation via macrophage activation. Eventually, we identified research gaps and recommended several primary directions for further studies.

Automated summary

This review summarizes recent advances in lactylation in lactate metabolism and diseases. Lactylation plays a vital role in cancer, inflammation, and regeneration, but the specific mechanism is still unclear. Histone lactylation regulates oncogenic processes and inflammation through gene transcription and macrophage activation.